Table 3

Relative changes of IGF-I, IGFBP-3, and their molar ratio during the 5 years of intervention

Data are expressed as the mean ratio (and 95% CI) between baseline and yearly measurements.
IGF and yearAge ≤50 yearsAge >50 years
FenretinideControlFenretinideControl
nGeometric mean (95% CI)nGeometric mean (95% CI)nGeometric mean (95% CI)nGeometric mean (95% CI)
IGF-I
1250.84 (0.75–0.95)280.97 (0.86–1.10)240.92 (0.83–1.01)280.98 (0.88–1.08)
2210.89 (0.78–1.01)90.90 (0.76–1.07)230.85 (0.77–0.93)151.00 (0.80–1.25)
3170.88 (0.79–0.98)90.99 (0.81–1.21)110.89 (0.67–1.19)80.86 (0.63–1.17)
4141.02 (0.88–1.18)40.83 (0.50–1.40)160.82 (0.70–0.95)51.11 (0.69–1.79)
5100.91 (0.72–1.15)90.89 (0.76–1.06)140.94 (0.80–1.09)91.06 (0.78–1.43)
IGFBP-3
1250.88 (0.80–0.96)270.92 (0.84–1.00)240.96 (0.91–1.01)280.98 (0.93–1.03)
2210.81 (0.73–0.91)80.95 (0.86–1.05)230.99 (0.95–1.04)150.97 (0.90–1.05)
3170.85 (0.77–0.94)80.87 (0.72–1.06)111.00 (0.93–1.07)80.88 (0.83–0.95)
4140.90 (0.77–1.05)40.98 (0.74–1.31)160.97 (0.92–1.02)50.95 (0.82–1.10)
5100.90 (0.80–1.02)90.96 (0.85–1.07)140.97 (0.90–1.06)91.01 (0.91–1.13)
IGF-I:GFBP3
1250.96 (0.86–1.08)271.08 (0.97–1.20)240.95 (0.88–1.04)281.00 (0.91–1.10)
2211.09 (0.95–1.24)81.00 (0.90–1.12)230.85 (0.77–0.94)151.02 (0.81–1.29)
3171.04 (0.92–1.16)81.22 (1.08–1.39)110.89 (0.66–1.21)80.97 (0.69–1.39)
4141.13 (0.96–1.33)40.85 (0.65–1.10)160.84 (0.73–0.97)51.17 (0.66–2.09)
5101.01 (0.83–1.23)90.94 (0.78–1.12)140.96 (0.82–1.12)91.05 (0.77–1.43)