PT  - JOURNAL ARTICLE
AU  - Morra, Anna
AU  - Jung, Audrey Y.
AU  - Behrens, Sabine
AU  - Keeman, Renske
AU  - Ahearn, Thomas U.
AU  - Anton-Culver, Hoda
AU  - Arndt, Volker
AU  - Augustinsson, Annelie
AU  - Auvinen, Päivi K.
AU  - Beane Freeman, Laura E.
AU  - Becher, Heiko
AU  - Beckmann, Matthias W.
AU  - Blomqvist, Carl
AU  - Bojesen, Stig E.
AU  - Bolla, Manjeet K.
AU  - Brenner, Hermann
AU  - Briceno, Ignacio
AU  - Brucker, Sara Y.
AU  - Camp, Nicola J.
AU  - Campa, Daniele
AU  - Canzian, Federico
AU  - Castelao, Jose E.
AU  - Chanock, Stephen J.
AU  - Choi, Ji-Yeob
AU  - Clarke, Christine L.
AU  - Couch, Fergus J.
AU  - Cox, Angela
AU  - Cross, Simon S.
AU  - Czene, Kamila
AU  - Dörk, Thilo
AU  - Dunning, Alison M.
AU  - Dwek, Miriam
AU  - Easton, Douglas F.
AU  - Eccles, Diana M.
AU  - Egan, Kathleen M.
AU  - Evans, D. Gareth
AU  - Fasching, Peter A.
AU  - Flyger, Henrik
AU  - Gago-Dominguez, Manuela
AU  - Gapstur, Susan M.
AU  - García-Sáenz, José A.
AU  - Gaudet, Mia M.
AU  - Giles, Graham G.
AU  - Grip, Mervi
AU  - Guénel, Pascal
AU  - Haiman, Christopher A.
AU  - Håkansson, Niclas
AU  - Hall, Per
AU  - Hamann, Ute
AU  - Han, Sileny N.
AU  - Hart, Steven N.
AU  - Hartman, Mikael
AU  - Heyworth, Jane S.
AU  - Hoppe, Reiner
AU  - Hopper, John L.
AU  - Hunter, David J.
AU  - Ito, Hidemi
AU  - Jager, Agnes
AU  - Jakimovska, Milena
AU  - Jakubowska, Anna
AU  - Janni, Wolfgang
AU  - Kaaks, Rudolf
AU  - Kang, Daehee
AU  - Kapoor, Pooja Middha
AU  - Kitahara, Cari M.
AU  - Koutros, Stella
AU  - Kraft, Peter
AU  - Kristensen, Vessela N.
AU  - Lacey, James V.
AU  - Lambrechts, Diether
AU  - Le Marchand, Loic
AU  - Li, Jingmei
AU  - Lindblom, Annika
AU  - Lubiński, Jan
AU  - Lush, Michael
AU  - Mannermaa, Arto
AU  - Manoochehri, Mehdi
AU  - Margolin, Sara
AU  - Mariapun, Shivaani
AU  - Matsuo, Keitaro
AU  - Mavroudis, Dimitrios
AU  - Milne, Roger L.
AU  - Muranen, Taru A.
AU  - Newman, William G.
AU  - Noh, Dong-Young
AU  - Nordestgaard, Børge G.
AU  - Obi, Nadia
AU  - Olshan, Andrew F.
AU  - Olsson, Håkan
AU  - Park-Simon, Tjoung-Won
AU  - Petridis, Christos
AU  - Pharoah, Paul D.P.
AU  - Plaseska-Karanfilska, Dijana
AU  - Presneau, Nadege
AU  - Rashid, Muhammad U.
AU  - Rennert, Gad
AU  - Rennert, Hedy S.
AU  - Rhenius, Valerie
AU  - Romero, Atocha
AU  - Saloustros, Emmanouil
AU  - Sawyer, Elinor J.
AU  - Schneeweiss, Andreas
AU  - Schwentner, Lukas
AU  - Scott, Christopher
AU  - Shah, Mitul
AU  - Shen, Chen-Yang
AU  - Shu, Xiao-Ou
AU  - Southey, Melissa C.
AU  - Stram, Daniel O.
AU  - Tamimi, Rulla M.
AU  - Tapper, William
AU  - Tollenaar, Rob A.E.M.
AU  - Tomlinson, Ian
AU  - Torres, Diana
AU  - Troester, Melissa A.
AU  - Truong, Thérèse
AU  - Vachon, Celine M.
AU  - Wang, Qin
AU  - Wang, Sophia S.
AU  - Williams, Justin A.
AU  - Winqvist, Robert
AU  - Wolk, Alicja
AU  - Wu, Anna H.
AU  - Yoo, Keun-Young
AU  - Yu, Jyh-Cherng
AU  - Zheng, Wei
AU  - Ziogas, Argyrios
AU  - Yang, Xiaohong R.
AU  - Eliassen, A. Heather
AU  - Holmes, Michelle D.
AU  - García-Closas, Montserrat
AU  - Teo, Soo Hwang
AU  - Schmidt, Marjanka K.
AU  - Chang-Claude, Jenny
TI  - Breast Cancer Risk Factors and Survival by Tumor Subtype: Pooled Analyses from the Breast Cancer Association Consortium
AID  - 10.1158/1055-9965.EPI-20-0924
DP  - 2021 Apr 01
TA  - Cancer Epidemiology Biomarkers & Prevention
PG  - 623--642
VI  - 30
IP  - 4
4099  - http://cebp.aacrjournals.org/content/30/4/623.short
4100  - http://cebp.aacrjournals.org/content/30/4/623.full
SO  - Cancer Epidemiol Biomarkers Prev2021 Apr 01; 30
AB  - Background: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype.Methods: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 breast cancer specific) over 10 years. Cox regression was used to estimate associations between risk factors and 10-year all-cause mortality and breast cancer–specific mortality overall, by estrogen receptor (ER) status, and by intrinsic-like subtype.Results: There was no evidence of heterogeneous associations between risk factors and mortality by subtype (Padj > 0.30). The strongest associations were between all-cause mortality and BMI ≥30 versus 18.5–25 kg/m2 [HR (95% confidence interval (CI), 1.19 (1.06–1.34)]; current versus never smoking [1.37 (1.27–1.47)], high versus low physical activity [0.43 (0.21–0.86)], age ≥30 years versus <20 years at first pregnancy [0.79 (0.72–0.86)]; >0–<5 years versus ≥10 years since last full-term birth [1.31 (1.11–1.55)]; ever versus never use of oral contraceptives [0.91 (0.87–0.96)]; ever versus never use of menopausal hormone therapy, including current estrogen–progestin therapy [0.61 (0.54–0.69)]. Similar associations with breast cancer mortality were weaker; for example, 1.11 (1.02–1.21) for current versus never smoking.Conclusions: We confirm associations between modifiable lifestyle factors and 10-year all-cause mortality. There was no strong evidence that associations differed by ER status or intrinsic-like subtype.Impact: Given the large dataset and lack of evidence that associations between modifiable risk factors and 10-year mortality differed by subtype, these associations could be cautiously used in prognostication models to inform patient-centered care.