PT  - JOURNAL ARTICLE
AU  - Al Ramadhani, Ruqaiya M.
AU  - Nagle, Christina M.
AU  - Ibiebele, Torukiri I.
AU  - Grant, Peter
AU  - Friedlander, Michael
AU  - DeFazio, Anna
AU  - Webb, Penelope M.
TI  - Pre- and Post-Diagnosis Diet Quality and Ovarian Cancer Survival
AID  - 10.1158/1055-9965.EPI-20-1036
DP  - 2021 Jan 01
TA  - Cancer Epidemiology Biomarkers & Prevention
PG  - 229--232
VI  - 30
IP  - 1
4099  - http://cebp.aacrjournals.org/content/30/1/229.short
4100  - http://cebp.aacrjournals.org/content/30/1/229.full
SO  - Cancer Epidemiol Biomarkers Prev2021 Jan 01; 30
AB  - Background: Prior studies evaluating diet quality in relation to ovarian cancer survival are sparse, and to date none have assessed diet quality or diet-quality change after diagnosis.Methods: In the prospective Ovarian cancer Prognosis And Lifestyle (OPAL) study, diet-quality scores were calculated using data from food frequency questionnaires completed pre-diagnosis (n = 650) and 12 months' post-diagnosis (n = 503). We used Cox proportional hazard models to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the association between diet quality and survival.Results: During the median follow-up of 4.4 years, 278 women died from ovarian cancer. There was no evidence of an association between diet quality pre- or post-diagnosis and progression-free, overall, or ovarian cancer–specific survival. No survival advantage was observed for women who had either improved their diet quality or who consumed a high-quality diet both before and 12 months after diagnosis.Conclusions: Higher pre- and post-diagnosis diet quality was not associated with better survival outcomes in this cohort of women with ovarian cancer.Impact: Diet quality is important for a range of health outcomes but may not improve survival after a diagnosis of ovarian cancer.