RT Journal Article
SR Electronic
T1 Mendelian Randomization Analysis of n-6 Polyunsaturated Fatty Acid Levels and Pancreatic Cancer Risk
JF Cancer Epidemiology Biomarkers & Prevention
JO Cancer Epidemiol Biomarkers Prev
FD American Association for Cancer Research
DO 10.1158/1055-9965.EPI-20-0651
A1 Ghoneim, Dalia H.
A1 Zhu, Jingjing
A1 Zheng, Wei
A1 Long, Jirong
A1 Murff, Harvey J.
A1 Ye, Fei
A1 Setiawan, Veronica Wendy
A1 Wilkens, Lynne R.
A1 Khankari, Nikhil K.
A1 Haycock, Philip
A1 Antwi, Samuel O.
A1 Yang, Yaohua
A1 Arslan, Alan A.
A1 Beane Freeman, Laura E.
A1 Bracci, Paige M.
A1 Canzian, Federico
A1 Du, Mengmeng
A1 Gallinger, Steven
A1 Giles, Graham G.
A1 Goodman, Phyllis J.
A1 Kooperberg, Charles
A1 Le Marchand, Loic
A1 Neale, Rachel E.
A1 Scelo, Ghislaine
A1 Visvanathan, Kala
A1 White, Emily
A1 Albanes, Demetrius
A1 Amiano, Pilar
A1 Andreotti, Gabriella
A1 Babic, Ana
A1 Bamlet, William R.
A1 Berndt, Sonja I.
A1 Brais, Lauren K.
A1 Brennan, Paul
A1 Bueno-de-Mesquita, Bas
A1 Buring, Julie E.
A1 Campbell, Peter T.
A1 Rabe, Kari G.
A1 Chanock, Stephen J.
A1 Duggal, Priya
A1 Fuchs, Charles S.
A1 Gaziano, J. Michael
A1 Goggins, Michael G.
A1 Hackert, Thilo
A1 Hassan, Manal M.
A1 Helzlsouer, Kathy J.
A1 Holly, Elizabeth A.
A1 Hoover, Robert N.
A1 Katske, Verena
A1 Kurtz, Robert C.
A1 Lee, I-Min
A1 Malats, Núria
A1 Milne, Roger L.
A1 Murphy, Neil
A1 Oberg, Ann L.
A1 Porta, Miquel
A1 Rothman, Nathaniel
A1 Sesso, Howard D.
A1 Silverman, Debra T.
A1 Thompson, Ian M.
A1 Wactawski-Wende, Jean
A1 Wang, Xiaoliang
A1 Wentzensen, Nicolas
A1 Yu, Herbert
A1 Zeleniuch-Jacquotte, Anne
A1 Yu, Kai
A1 Wolpin, Brian M.
A1 Jacobs, Eric J.
A1 Duell, Eric J.
A1 Risch, Harvey A.
A1 Petersen, Gloria M.
A1 Amundadottir, Laufey T.
A1 Kraft, Peter
A1 Klein, Alison P.
A1 Stolzenberg-Solomon, Rachel Z.
A1 Shu, Xiao-Ou
A1 Wu, Lang
YR 2020
UL http://cebp.aacrjournals.org/content/early/2020/10/06/1055-9965.EPI-20-0651.abstract
AB Background: Whether circulating polyunsaturated fatty acid (PUFA) levels are associated with pancreatic cancer risk is uncertain. Mendelian randomization (MR) represents a study design using genetic instruments to better characterize the relationship between exposure and outcome.Methods: We utilized data from genome-wide association studies within the Pancreatic Cancer Cohort Consortium and Pancreatic Cancer Case–Control Consortium, involving approximately 9,269 cases and 12,530 controls of European descent, to evaluate associations between pancreatic cancer risk and genetically predicted plasma n-6 PUFA levels. Conventional MR analyses were performed using individual-level and summary-level data.Results: Using genetic instruments, we did not find evidence of associations between genetically predicted plasma n-6 PUFA levels and pancreatic cancer risk [estimates per one SD increase in each PUFA-specific weighted genetic score using summary statistics: linoleic acid odds ratio (OR) = 1.00, 95% confidence interval (CI) = 0.98–1.02; arachidonic acid OR = 1.00, 95% CI = 0.99–1.01; and dihomo-gamma-linolenic acid OR = 0.95, 95% CI = 0.87–1.02]. The OR estimates remained virtually unchanged after adjustment for covariates, using individual-level data or summary statistics, or stratification by age and sex.Conclusions: Our results suggest that variations of genetically determined plasma n-6 PUFA levels are not associated with pancreatic cancer risk.Impact: These results suggest that modifying n-6 PUFA levels through food sources or supplementation may not influence risk of pancreatic cancer.