RT Journal Article SR Electronic T1 Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression JF Cancer Epidemiology Biomarkers & Prevention JO Cancer Epidemiol Biomarkers Prev FD American Association for Cancer Research SP 133 OP 140 DO 10.1158/1055-9965.EPI-19-0325 VO 29 IS 1 A1 Shi, Yan A1 Liu, Li A1 Hamada, Tsuyoshi A1 Nowak, Jonathan A. A1 Giannakis, Marios A1 Ma, Yanan A1 Song, Mingyang A1 Nevo, Daniel A1 Kosumi, Keisuke A1 Gu, Mancang A1 Kim, Sun A. A1 Morikawa, Teppei A1 Wu, Kana A1 Sui, Jing A1 Papantoniou, Kyriaki A1 Wang, Molin A1 Chan, Andrew T. A1 Fuchs, Charles S. A1 Meyerhardt, Jeffrey A. A1 Giovannucci, Edward A1 Ogino, Shuji A1 Schernhammer, Eva S. A1 Nishihara, Reiko A1 Zhang, Xuehong YR 2020 UL http://cebp.aacrjournals.org/content/29/1/133.abstract AB Background: We hypothesized that the risk of colorectal cancer in night-shift workers might be different according to insulin receptor substrate status.Methods: Among 77,470 eligible women having night work assessed in the Nurses' Health Study, we documented a total of 1,397 colorectal cancer cases, of which 304 or 308 had available data on IRS1 and IRS2, respectively. We used duplication-method Cox proportional hazards regression analysis for competing risks to calculate HRs and 95% confidence intervals (CI) for each colorectal cancer subtype. We measured tumor IRS1 or IRS2 expression by immunohistochemistry (IHC).Results: Compared with women who never worked night shifts, those working ≥15 years night shifts had a marginal trend of increased overall risk of colorectal cancer (Ptrend = 0.06; multivariable HR = 1.20; 95% CI, 0.99–1.45). Longer duration of night-shift work was associated with a higher risk of IRS2-positive tumors (multivariable HR = 2.69; 95% CI, 1.48–4.89; Ptrend = 0.001, ≥15 years night shifts vs. never) but not with IRS2-negative tumors (multivariable HR = 0.90; 95% CI, 0.54–1.51; Ptrend = 0.72; Pheterogeneity for IRS2 = 0.008). Similarly, the corresponding multivariable HRs were 1.81 for IRS1-positive tumors (95% CI, 0.94–3.48; Ptrend = 0.06) and 1.13 for IRS1-negative tumors (95% CI, 0.71–1.80; Ptrend = 0.56; Pheterogeneity for IRS1 = 0.02).Conclusions: Our molecular pathologic epidemiology data suggest a potential role of IRS in mediating carcinogenesis induced by night-shift work.Impact: Although these findings need validation, rotating night shift might increase colorectal cancer risk in women with abnormal insulin receptor pathways.