RT Journal Article
SR Electronic
T1 Night-Shift Work Duration and Risk of Colorectal Cancer According to <em>IRS1</em> and <em>IRS2</em> Expression
JF Cancer Epidemiology Biomarkers &amp; Prevention
JO Cancer Epidemiol Biomarkers Prev
FD American Association for Cancer Research
SP 133
OP 140
DO 10.1158/1055-9965.EPI-19-0325
VO 29
IS 1
A1 Shi, Yan
A1 Liu, Li
A1 Hamada, Tsuyoshi
A1 Nowak, Jonathan A.
A1 Giannakis, Marios
A1 Ma, Yanan
A1 Song, Mingyang
A1 Nevo, Daniel
A1 Kosumi, Keisuke
A1 Gu, Mancang
A1 Kim, Sun A.
A1 Morikawa, Teppei
A1 Wu, Kana
A1 Sui, Jing
A1 Papantoniou, Kyriaki
A1 Wang, Molin
A1 Chan, Andrew T.
A1 Fuchs, Charles S.
A1 Meyerhardt, Jeffrey A.
A1 Giovannucci, Edward
A1 Ogino, Shuji
A1 Schernhammer, Eva S.
A1 Nishihara, Reiko
A1 Zhang, Xuehong
YR 2020
UL http://cebp.aacrjournals.org/content/29/1/133.abstract
AB Background: We hypothesized that the risk of colorectal cancer in night-shift workers might be different according to insulin receptor substrate status.Methods: Among 77,470 eligible women having night work assessed in the Nurses' Health Study, we documented a total of 1,397 colorectal cancer cases, of which 304 or 308 had available data on IRS1 and IRS2, respectively. We used duplication-method Cox proportional hazards regression analysis for competing risks to calculate HRs and 95% confidence intervals (CI) for each colorectal cancer subtype. We measured tumor IRS1 or IRS2 expression by immunohistochemistry (IHC).Results: Compared with women who never worked night shifts, those working ≥15 years night shifts had a marginal trend of increased overall risk of colorectal cancer (Ptrend = 0.06; multivariable HR = 1.20; 95% CI, 0.99–1.45). Longer duration of night-shift work was associated with a higher risk of IRS2-positive tumors (multivariable HR = 2.69; 95% CI, 1.48–4.89; Ptrend = 0.001, ≥15 years night shifts vs. never) but not with IRS2-negative tumors (multivariable HR = 0.90; 95% CI, 0.54–1.51; Ptrend = 0.72; Pheterogeneity for IRS2 = 0.008). Similarly, the corresponding multivariable HRs were 1.81 for IRS1-positive tumors (95% CI, 0.94–3.48; Ptrend = 0.06) and 1.13 for IRS1-negative tumors (95% CI, 0.71–1.80; Ptrend = 0.56; Pheterogeneity for IRS1 = 0.02).Conclusions: Our molecular pathologic epidemiology data suggest a potential role of IRS in mediating carcinogenesis induced by night-shift work.Impact: Although these findings need validation, rotating night shift might increase colorectal cancer risk in women with abnormal insulin receptor pathways.