PT  - JOURNAL ARTICLE
AU  - Xu, Xin
TI  - Processed Meat Intake and Bladder Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cohort
AID  - 10.1158/1055-9965.EPI-19-0604
DP  - 2019 Dec 01
TA  - Cancer Epidemiology Biomarkers & Prevention
PG  - 1993--1997
VI  - 28
IP  - 12
4099  - http://cebp.aacrjournals.org/content/28/12/1993.short
4100  - http://cebp.aacrjournals.org/content/28/12/1993.full
SO  - Cancer Epidemiol Biomarkers Prev2019 Dec 01; 28
AB  - Background: The association between processed meat intake and bladder cancer risk has been evaluated by several observational studies with inconsistent results.Methods: In a cohort of 101,721 subjects in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, we analyzed the association of processed meat intake with bladder cancer risk.Results: After a median of 12.5 years of follow-up, 776 new cases of bladder cancer were identified. Intake of processed red meat was significantly associated with the incidence of bladder cancer after multivariate adjustment [highest vs. lowest quintile: HR, 1.47; 95% confidence interval (CI), 1.12–1.93; Ptrend = 0.008]. In contrast, there was only a suggestive but not significant association between intake of total processed meat and bladder cancer risk after multivariable adjustment (highest vs. lowest quintile: HR, 1.16; 95% CI, 0.89–1.50; Ptrend = 0.073).Conclusions: This large prospective study suggests that intake of processed red meat is associated with a higher risk of bladder cancer.Impact: Bladder cancer risk is increased with cumulative intake of processed red meat.This article is featured in Highlights of This Issue, p. 1947