RT Journal Article
SR Electronic
T1 Prediagnostic Leukocyte Telomere Length and Pancreatic Cancer Survival
JF Cancer Epidemiology Biomarkers & Prevention
JO Cancer Epidemiol Biomarkers Prev
FD American Association for Cancer Research
SP 1868
OP 1875
DO 10.1158/1055-9965.EPI-19-0577
VO 28
IS 11
A1 Hamada, Tsuyoshi
A1 Yuan, Chen
A1 Bao, Ying
A1 Zhang, Mingfeng
A1 Khalaf, Natalia
A1 Babic, Ana
A1 Morales-Oyarvide, Vicente
A1 Cochrane, Barbara B.
A1 Gaziano, J. Michael
A1 Giovannucci, Edward L.
A1 Kraft, Peter
A1 Manson, JoAnn E.
A1 Ng, Kimmie
A1 Nowak, Jonathan A.
A1 Rohan, Thomas E.
A1 Sesso, Howard D.
A1 Stampfer, Meir J.
A1 Amundadottir, Laufey T.
A1 Fuchs, Charles S.
A1 De Vivo, Immaculata
A1 Ogino, Shuji
A1 Wolpin, Brian M.
YR 2019
UL http://cebp.aacrjournals.org/content/28/11/1868.abstract
AB Background: Leukocyte telomere length has been associated with risk of subsequent pancreatic cancer. Few prospective studies have evaluated the association of prediagnostic leukocyte telomere length with pancreatic cancer survival.Methods: We prospectively examined the association of prediagnostic leukocyte telomere length with overall survival (OS) time among 423 participants diagnosed with pancreatic adenocarcinoma between 1984 and 2008 within the Health Professionals Follow-up Study, Nurses' Health Study, Physicians' Health Study, and Women's Health Initiative. We measured prediagnostic leukocyte telomere length in banked blood samples using quantitative PCR. Cox proportional hazards models were used to estimate HRs for OS with adjustment for potential confounders. We also evaluated 10 SNPs at the telomerase reverse transcriptase locus.Results: Shorter prediagnostic leukocyte telomere length was associated with reduced OS among patients with pancreatic cancer (Ptrend = 0.04). The multivariable-adjusted HR for OS comparing the lowest with highest quintiles of leukocyte telomere length was 1.39 (95% confidence interval, 1.01–1.93), corresponding to a 3-month difference in median OS time. In an analysis excluding cases with blood collected within 2 years of cancer diagnosis, the association was moderately stronger (HR, 1.55; 95% confidence interval, 1.09–2.21; comparing the lowest with highest quintiles; Ptrend = 0.01). No prognostic association or effect modification for the prognostic association of prediagnostic leukocyte telomere length was noted in relation to the studied SNPs.Conclusions: Prediagnostic leukocyte telomere length was associated with pancreatic cancer survival.Impact: Prediagnostic leukocyte telomere length can be a prognostic biomarker in pancreatic cancer.This article is featured in Highlights of This Issue, p. 1769