RT Journal Article
SR Electronic
T1 Association of Pancreatic Cancer Susceptibility Variants with Risk of Breast Cancer in Women of European and African Ancestry
JF Cancer Epidemiology Biomarkers & Prevention
JO Cancer Epidemiol Biomarkers Prev
FD American Association for Cancer Research
SP 116
OP 118
DO 10.1158/1055-9965.EPI-17-0755
VO 27
IS 1
A1 Wang, Shengfeng
A1 Zheng, Yonglan
A1 Ogundiran, Temidayo O.
A1 Ojengbede, Oladosu
A1 Zheng, Wei
A1 Nathanson, Katherine L.
A1 Nemesure, Barbara
A1 Ambs, Stefan
A1 Olopade, Olufunmilayo I.
A1 Huo, Dezheng
YR 2018
UL http://cebp.aacrjournals.org/content/27/1/116.abstract
AB Background: Pancreatic cancer mutation signatures closely resemble breast cancer, suggesting that both cancers may have common predisposition mechanisms that may include commonly inherited SNPs.Methods: We examined 23 genetic variants known to be associated with pancreatic cancer as breast cancer risk factors in the Root genome-wide association study (GWAS; 1,657 cases and 2,029 controls of African diaspora) and GAME-ON/DRIVE GWAS (16,003 cases and 41,335 controls of European ancestry).Results: None of the pancreatic cancer susceptibility variants were individually associated with breast cancer risk after adjustment for multiple testing (at α = 0.002) in the two populations. In Root GWAS, a change by one SD in the polygenic risk score (PRS) was not significantly associated with breast cancer. In addition, we did not observe a trend in the relationship between PRS percentiles and breast cancer risk.Conclusions: The association between reported pancreatic cancer genetic susceptibility variants and breast cancer development in women of African or European ancestry is likely weak, if it does exist.Impact: Known GWAS-derived susceptibility variants of pancreatic cancer do not explain its shared genetic etiology with breast cancer. Cancer Epidemiol Biomarkers Prev; 27(1); 116–8. ©2017 AACR.