RT Journal Article SR Electronic T1 No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival JF Cancer Epidemiology Biomarkers & Prevention JO Cancer Epidemiol Biomarkers Prev FD American Association for Cancer Research SP 420 OP 424 DO 10.1158/1055-9965.EPI-16-0631 VO 26 IS 3 A1 Sucheston-Campbell, Lara E. A1 Cannioto, Rikki A1 Clay, Alyssa I. A1 Etter, John Lewis A1 Eng, Kevin H. A1 Liu, Song A1 Battaglia, Sebastiano A1 Hu, Qiang A1 Szender, J. Brian A1 Minlikeeva, Albina A1 Joseph, Janine M. A1 Mayor, Paul A1 Abrams, Scott I. A1 Segal, Brahm H. A1 Wallace, Paul K. A1 Soh, Kah Teong A1 Zsiros, Emese A1 Anton-Culver, Hoda A1 Bandera, Elisa V. A1 Beckmann, Matthias W. A1 Berchuck, Andrew A1 Bjorge, Line A1 Bruegl, Amanda A1 Campbell, Ian G. A1 Campbell, Shawn Patrice A1 Chenevix-Trench, Georgia A1 Cramer, Daniel W. A1 Dansonka-Mieszkowska, Agnieszka A1 Dao, Fanny A1 Diergaarde, Brenda A1 Doerk, Thilo A1 Doherty, Jennifer A. A1 du Bois, Andreas A1 Eccles, Diana A1 Engelholm, Svend Aage A1 Fasching, Peter A. A1 Gayther, Simon A. A1 Gentry-Maharaj, Aleksandra A1 Glasspool, Rosalind M. A1 Goodman, Marc T. A1 Gronwald, Jacek A1 Harter, Philipp A1 Hein, Alexander A1 Heitz, Florian A1 Hillemmanns, Peter A1 Høgdall, Claus A1 Høgdall, Estrid V.S. A1 Huzarski, Tomasz A1 Jensen, Allan A1 Johnatty, Sharon E. A1 Jung, Audrey A1 Karlan, Beth Y. A1 Klapdor, Reudiger A1 Kluz, Tomasz A1 Konopka, Bożena A1 Kjær, Susanne Krüger A1 Kupryjanczyk, Jolanta A1 Lambrechts, Diether A1 Lester, Jenny A1 Lubiński, Jan A1 Levine, Douglas A. A1 Lundvall, Lene A1 McGuire, Valerie A1 McNeish, Iain A. A1 Menon, Usha A1 Modugno, Francesmary A1 Ness, Roberta B. A1 Orsulic, Sandra A1 Paul, James A1 Pearce, Celeste Leigh A1 Pejovic, Tanja A1 Pharoah, Paul A1 Ramus, Susan J. A1 Rothstein, Joseph A1 Rossing, Mary Anne A1 Rübner, Matthias A1 Schildkraut, Joellen M. A1 Schmalfeldt, Barbara A1 Schwaab, Ira A1 Siddiqui, Nadeem A1 Sieh, Weiva A1 Sobiczewski, Piotr A1 Song, Honglin A1 Terry, Kathryn L. A1 Van Nieuwenhuysen, Els A1 Vanderstichele, Adriaan A1 Vergote, Ignace A1 Walsh, Christine S. A1 Webb, Penelope M. A1 Wentzensen, Nicolas A1 Whittemore, Alice S. A1 Wu, Anna H. A1 Ziogas, Argyrios A1 Odunsi, Kunle A1 Chang-Claude, Jenny A1 Goode, Ellen L. A1 Moysich, Kirsten B. YR 2017 UL http://cebp.aacrjournals.org/content/26/3/420.abstract AB Background: The precise mechanism by which the immune system is adversely affected in cancer patients remains poorly understood, but the accumulation of immunosuppressive/protumorigenic myeloid-derived suppressor cells (MDSCs) is thought to be a prominent mechanism contributing to immunologic tolerance of malignant cells in epithelial ovarian cancer (EOC). To this end, we hypothesized genetic variation in MDSC pathway genes would be associated with survival after EOC diagnoses.Methods: We measured the hazard of death due to EOC within 10 years of diagnosis, overall and by invasive subtype, attributable to SNPs in 24 genes relevant in the MDSC pathway in 10,751 women diagnosed with invasive EOC. Versatile Gene-based Association Study and the admixture likelihood method were used to test gene and pathway associations with survival.Results: We did not identify individual SNPs that were significantly associated with survival after correction for multiple testing (P < 3.5 × 10−5), nor did we identify significant associations between the MDSC pathway overall, or the 24 individual genes and EOC survival.Conclusions: In this well-powered analysis, we observed no evidence that inherited variations in MDSC-associated SNPs, individual genes, or the collective genetic pathway contributed to EOC survival outcomes.Impact: Common inherited variation in genes relevant to MDSCs was not associated with survival in women diagnosed with invasive EOC. Cancer Epidemiol Biomarkers Prev; 26(3); 420–4. ©2016 AACR.