RT Journal Article
SR Electronic
T1 No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival
JF Cancer Epidemiology Biomarkers & Prevention
JO Cancer Epidemiol Biomarkers Prev
FD American Association for Cancer Research
SP 420
OP 424
DO 10.1158/1055-9965.EPI-16-0631
VO 26
IS 3
A1 Sucheston-Campbell, Lara E.
A1 Cannioto, Rikki
A1 Clay, Alyssa I.
A1 Etter, John Lewis
A1 Eng, Kevin H.
A1 Liu, Song
A1 Battaglia, Sebastiano
A1 Hu, Qiang
A1 Szender, J. Brian
A1 Minlikeeva, Albina
A1 Joseph, Janine M.
A1 Mayor, Paul
A1 Abrams, Scott I.
A1 Segal, Brahm H.
A1 Wallace, Paul K.
A1 Soh, Kah Teong
A1 Zsiros, Emese
A1 Anton-Culver, Hoda
A1 Bandera, Elisa V.
A1 Beckmann, Matthias W.
A1 Berchuck, Andrew
A1 Bjorge, Line
A1 Bruegl, Amanda
A1 Campbell, Ian G.
A1 Campbell, Shawn Patrice
A1 Chenevix-Trench, Georgia
A1 Cramer, Daniel W.
A1 Dansonka-Mieszkowska, Agnieszka
A1 Dao, Fanny
A1 Diergaarde, Brenda
A1 Doerk, Thilo
A1 Doherty, Jennifer A.
A1 du Bois, Andreas
A1 Eccles, Diana
A1 Engelholm, Svend Aage
A1 Fasching, Peter A.
A1 Gayther, Simon A.
A1 Gentry-Maharaj, Aleksandra
A1 Glasspool, Rosalind M.
A1 Goodman, Marc T.
A1 Gronwald, Jacek
A1 Harter, Philipp
A1 Hein, Alexander
A1 Heitz, Florian
A1 Hillemmanns, Peter
A1 Høgdall, Claus
A1 Høgdall, Estrid V.S.
A1 Huzarski, Tomasz
A1 Jensen, Allan
A1 Johnatty, Sharon E.
A1 Jung, Audrey
A1 Karlan, Beth Y.
A1 Klapdor, Reudiger
A1 Kluz, Tomasz
A1 Konopka, Bożena
A1 Kjær, Susanne Krüger
A1 Kupryjanczyk, Jolanta
A1 Lambrechts, Diether
A1 Lester, Jenny
A1 Lubiński, Jan
A1 Levine, Douglas A.
A1 Lundvall, Lene
A1 McGuire, Valerie
A1 McNeish, Iain A.
A1 Menon, Usha
A1 Modugno, Francesmary
A1 Ness, Roberta B.
A1 Orsulic, Sandra
A1 Paul, James
A1 Pearce, Celeste Leigh
A1 Pejovic, Tanja
A1 Pharoah, Paul
A1 Ramus, Susan J.
A1 Rothstein, Joseph
A1 Rossing, Mary Anne
A1 Rübner, Matthias
A1 Schildkraut, Joellen M.
A1 Schmalfeldt, Barbara
A1 Schwaab, Ira
A1 Siddiqui, Nadeem
A1 Sieh, Weiva
A1 Sobiczewski, Piotr
A1 Song, Honglin
A1 Terry, Kathryn L.
A1 Van Nieuwenhuysen, Els
A1 Vanderstichele, Adriaan
A1 Vergote, Ignace
A1 Walsh, Christine S.
A1 Webb, Penelope M.
A1 Wentzensen, Nicolas
A1 Whittemore, Alice S.
A1 Wu, Anna H.
A1 Ziogas, Argyrios
A1 Odunsi, Kunle
A1 Chang-Claude, Jenny
A1 Goode, Ellen L.
A1 Moysich, Kirsten B.
YR 2017
UL http://cebp.aacrjournals.org/content/26/3/420.abstract
AB Background: The precise mechanism by which the immune system is adversely affected in cancer patients remains poorly understood, but the accumulation of immunosuppressive/protumorigenic myeloid-derived suppressor cells (MDSCs) is thought to be a prominent mechanism contributing to immunologic tolerance of malignant cells in epithelial ovarian cancer (EOC). To this end, we hypothesized genetic variation in MDSC pathway genes would be associated with survival after EOC diagnoses.Methods: We measured the hazard of death due to EOC within 10 years of diagnosis, overall and by invasive subtype, attributable to SNPs in 24 genes relevant in the MDSC pathway in 10,751 women diagnosed with invasive EOC. Versatile Gene-based Association Study and the admixture likelihood method were used to test gene and pathway associations with survival.Results: We did not identify individual SNPs that were significantly associated with survival after correction for multiple testing (P < 3.5 × 10−5), nor did we identify significant associations between the MDSC pathway overall, or the 24 individual genes and EOC survival.Conclusions: In this well-powered analysis, we observed no evidence that inherited variations in MDSC-associated SNPs, individual genes, or the collective genetic pathway contributed to EOC survival outcomes.Impact: Common inherited variation in genes relevant to MDSCs was not associated with survival in women diagnosed with invasive EOC. Cancer Epidemiol Biomarkers Prev; 26(3); 420–4. ©2016 AACR.