PT  - JOURNAL ARTICLE
AU  - Gravel, Annie
AU  - Dubuc, Isabelle
AU  - Brooks-Wilson, Angela
AU  - Aronson, Kristan J.
AU  - Simard, Jacques
AU  - Velásquez-García, Héctor A.
AU  - Spinelli, John J.
AU  - Flamand, Louis
TI  - Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer
AID  - 10.1158/1055-9965.EPI-16-0735
DP  - 2017 Mar 01
TA  - Cancer Epidemiology Biomarkers & Prevention
PG  - 425--427
VI  - 26
IP  - 3
4099  - http://cebp.aacrjournals.org/content/26/3/425.short
4100  - http://cebp.aacrjournals.org/content/26/3/425.full
SO  - Cancer Epidemiol Biomarkers Prev2017 Mar 01; 26
AB  - Background: Inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) is a condition observed in approximately 1% of the population. Whether such a genetic alteration predisposes to cancer development in currently unknown. Two studies were conducted to determine whether iciHHV-6 is associated with cancer development.Methods: First, a screen of 19,597 people from the province of Quebec (Canada) was conducted. A replication test, using data from a population-based case–control study of 1,090 women with incident breast cancer and 1,053 controls from British Columbia and Ontario (Canada) was conducted. DNA samples were analyzed by qPCR and droplet digital PCR to identify iciHHV-6+ carriers.Results: In the initial study, a potential association between iciHHV-6 positivity and breast cancer was identified [OR = 2.66; 95% confidence interval (CI), 0.95–7.44]. In the replication dataset, no association was found between iciHHV-6 positivity in women and breast cancer (OR = 0.87; 95% CI, 0.35–2.15).Conclusions: We found no statistically significant associations between inherited chromosomally integrated HHV-6 and breast cancer in women.Impact: These results do not provide evidence to suggest that iciHHV-6 is a risk factor for breast cancer. Cancer Epidemiol Biomarkers Prev; 26(3); 425–7. ©2016 AACR.