RT Journal Article
SR Electronic
T1 The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers
JF Cancer Epidemiology Biomarkers & Prevention
JO Cancer Epidemiol Biomarkers Prev
FD American Association for Cancer Research
SP 126
OP 135
DO 10.1158/1055-9965.EPI-16-0106
VO 26
IS 1
A1 Amos, Christopher I.
A1 Dennis, Joe
A1 Wang, Zhaoming
A1 Byun, Jinyoung
A1 Schumacher, Fredrick R.
A1 Gayther, Simon A.
A1 Casey, Graham
A1 Hunter, David J.
A1 Sellers, Thomas A.
A1 Gruber, Stephen B.
A1 Dunning, Alison M.
A1 Michailidou, Kyriaki
A1 Fachal, Laura
A1 Doheny, Kimberly
A1 Spurdle, Amanda B.
A1 Li, Yafang
A1 Xiao, Xiangjun
A1 Romm, Jane
A1 Pugh, Elizabeth
A1 Coetzee, Gerhard A.
A1 Hazelett, Dennis J.
A1 Bojesen, Stig E.
A1 Caga-Anan, Charlisse
A1 Haiman, Christopher A.
A1 Kamal, Ahsan
A1 Luccarini, Craig
A1 Tessier, Daniel
A1 Vincent, Daniel
A1 Bacot, François
A1 Van Den Berg, David J.
A1 Nelson, Stefanie
A1 Demetriades, Stephen
A1 Goldgar, David E.
A1 Couch, Fergus J.
A1 Forman, Judith L.
A1 Giles, Graham G.
A1 Conti, David V.
A1 Bickeböller, Heike
A1 Risch, Angela
A1 Waldenberger, Melanie
A1 Brüske-Hohlfeld, Irene
A1 Hicks, Belynda D.
A1 Ling, Hua
A1 McGuffog, Lesley
A1 Lee, Andrew
A1 Kuchenbaecker, Karoline
A1 Soucy, Penny
A1 Manz, Judith
A1 Cunningham, Julie M.
A1 Butterbach, Katja
A1 Kote-Jarai, Zsofia
A1 Kraft, Peter
A1 FitzGerald, Liesel
A1 Lindström, Sara
A1 Adams, Marcia
A1 McKay, James D.
A1 Phelan, Catherine M.
A1 Benlloch, Sara
A1 Kelemen, Linda E.
A1 Brennan, Paul
A1 Riggan, Marjorie
A1 O'Mara, Tracy A.
A1 Shen, Hongbing
A1 Shi, Yongyong
A1 Thompson, Deborah J.
A1 Goodman, Marc T.
A1 Nielsen, Sune F.
A1 Berchuck, Andrew
A1 Laboissiere, Sylvie
A1 Schmit, Stephanie L.
A1 Shelford, Tameka
A1 Edlund, Christopher K.
A1 Taylor, Jack A.
A1 Field, John K.
A1 Park, Sue K.
A1 Offit, Kenneth
A1 Thomassen, Mads
A1 Schmutzler, Rita
A1 Ottini, Laura
A1 Hung, Rayjean J.
A1 Marchini, Jonathan
A1 Amin Al Olama, Ali
A1 Peters, Ulrike
A1 Eeles, Rosalind A.
A1 Seldin, Michael F.
A1 Gillanders, Elizabeth
A1 Seminara, Daniela
A1 Antoniou, Antonis C.
A1 Pharoah, Paul D.P.
A1 Chenevix-Trench, Georgia
A1 Chanock, Stephen J.
A1 Simard, Jacques
A1 Easton, Douglas F.
YR 2017
UL http://cebp.aacrjournals.org/content/26/1/126.abstract
AB Background: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers, and cancer-related traits.Methods: The OncoArray can be genotyped using a novel technology developed by Illumina to facilitate efficient genotyping. The consortium developed standard approaches for selecting SNPs for study, for quality control of markers, and for ancestry analysis. The array was genotyped at selected sites and with prespecified replicate samples to permit evaluation of genotyping accuracy among centers and by ethnic background.Results: The OncoArray consortium genotyped 447,705 samples. A total of 494,763 SNPs passed quality control steps with a sample success rate of 97% of the samples. Participating sites performed ancestry analysis using a common set of markers and a scoring algorithm based on principal components analysis.Conclusions: Results from these analyses will enable researchers to identify new susceptibility loci, perform fine-mapping of new or known loci associated with either single or multiple cancers, assess the degree of overlap in cancer causation and pleiotropic effects of loci that have been identified for disease-specific risk, and jointly model genetic, environmental, and lifestyle-related exposures.Impact: Ongoing analyses will shed light on etiology and risk assessment for many types of cancer. Cancer Epidemiol Biomarkers Prev; 26(1); 126–35. ©2016 AACR.