RT Journal Article SR Electronic T1 Family History of Cancer in Relation to Breast Cancer Subtypes in African American Women JF Cancer Epidemiology Biomarkers & Prevention JO Cancer Epidemiol Biomarkers Prev FD American Association for Cancer Research SP 366 OP 373 DO 10.1158/1055-9965.EPI-15-1068 VO 25 IS 2 A1 Bethea, Traci N. A1 Rosenberg, Lynn A1 Castro-Webb, Nelsy A1 Lunetta, Kathryn L. A1 Sucheston-Campbell, Lara E. A1 Ruiz-Narváez, Edward A. A1 Charlot, Marjory A1 Park, Song-Yi A1 Bandera, Elisa V. A1 Troester, Melissa A. A1 Ambrosone, Christine B. A1 Palmer, Julie R. YR 2016 UL http://cebp.aacrjournals.org/content/25/2/366.abstract AB Background: The evidence on the relation of family history of cancers other than breast cancer to breast cancer risk is conflicting, and most studies have not assessed specific breast cancer subtypes.Methods: We assessed the relation of first-degree family history of breast, prostate, lung, colorectal, ovarian, and cervical cancer and lymphoma or leukemia, to the risk of estrogen receptor–positive (ER+), ER−, and triple-negative breast cancer in data from the African American Breast Cancer Epidemiology and Risk Consortium. Multivariable logistic regression models were used to calculate ORs and 95% confidence intervals (CI).Results: There were 3,023 ER+ and 1,497 ER− breast cancer cases (including 696 triple-negative cases) and 17,420 controls. First-degree family history of breast cancer was associated with increased risk of each subtype: OR = 1.76 (95% CI, 1.57–1.97) for ER+, 1.67 (1.42–1.95) for ER−, and 1.72 (1.38–2.13) for triple-negative breast cancer. Family history of cervical cancer was associated with increased risk of ER− (OR = 2.39; 95% CI, 1.36–4.20), but not ER+ cancer. Family history of both breast and prostate cancer was associated with increased risk of ER+ (3.40; 2.42–4.79) and ER− (2.09; 1.21–3.63) cancer, but family history of both breast and lung cancer was associated only with ER− cancer (2.11; 1.29–3.46).Conclusions: A family history of cancers other than breast may influence the risk of breast cancer, and associations may differ by subtype.Impact: Greater surveillance and counseling for additional screening may be warranted for women with a family history of cancer. Cancer Epidemiol Biomarkers Prev; 25(2); 366–73. ©2015 AACR.