PT - JOURNAL ARTICLE AU - Bethea, Traci N. AU - Rosenberg, Lynn AU - Castro-Webb, Nelsy AU - Lunetta, Kathryn L. AU - Sucheston-Campbell, Lara E. AU - Ruiz-Narváez, Edward A. AU - Charlot, Marjory AU - Park, Song-Yi AU - Bandera, Elisa V. AU - Troester, Melissa A. AU - Ambrosone, Christine B. AU - Palmer, Julie R. TI - Family History of Cancer in Relation to Breast Cancer Subtypes in African American Women AID - 10.1158/1055-9965.EPI-15-1068 DP - 2016 Feb 01 TA - Cancer Epidemiology Biomarkers & Prevention PG - 366--373 VI - 25 IP - 2 4099 - http://cebp.aacrjournals.org/content/25/2/366.short 4100 - http://cebp.aacrjournals.org/content/25/2/366.full SO - Cancer Epidemiol Biomarkers Prev2016 Feb 01; 25 AB - Background: The evidence on the relation of family history of cancers other than breast cancer to breast cancer risk is conflicting, and most studies have not assessed specific breast cancer subtypes.Methods: We assessed the relation of first-degree family history of breast, prostate, lung, colorectal, ovarian, and cervical cancer and lymphoma or leukemia, to the risk of estrogen receptor–positive (ER+), ER−, and triple-negative breast cancer in data from the African American Breast Cancer Epidemiology and Risk Consortium. Multivariable logistic regression models were used to calculate ORs and 95% confidence intervals (CI).Results: There were 3,023 ER+ and 1,497 ER− breast cancer cases (including 696 triple-negative cases) and 17,420 controls. First-degree family history of breast cancer was associated with increased risk of each subtype: OR = 1.76 (95% CI, 1.57–1.97) for ER+, 1.67 (1.42–1.95) for ER−, and 1.72 (1.38–2.13) for triple-negative breast cancer. Family history of cervical cancer was associated with increased risk of ER− (OR = 2.39; 95% CI, 1.36–4.20), but not ER+ cancer. Family history of both breast and prostate cancer was associated with increased risk of ER+ (3.40; 2.42–4.79) and ER− (2.09; 1.21–3.63) cancer, but family history of both breast and lung cancer was associated only with ER− cancer (2.11; 1.29–3.46).Conclusions: A family history of cancers other than breast may influence the risk of breast cancer, and associations may differ by subtype.Impact: Greater surveillance and counseling for additional screening may be warranted for women with a family history of cancer. Cancer Epidemiol Biomarkers Prev; 25(2); 366–73. ©2015 AACR.