PT  - JOURNAL ARTICLE
AU  - Tanton, Clare
AU  - Soldan, Kate
AU  - Beddows, Simon
AU  - Mercer, Catherine H.
AU  - Waller, Jo
AU  - Field, Nigel
AU  - Clifton, Soazig
AU  - Copas, Andrew J.
AU  - Panwar, Kavita
AU  - Manyenga, Precious
AU  - da Silva, Filomeno
AU  - Wellings, Kaye
AU  - Ison, Catherine A.
AU  - Johnson, Anne M.
AU  - Sonnenberg, Pam
TI  - High-Risk Human Papillomavirus (HPV) Infection and Cervical Cancer Prevention in Britain: Evidence of Differential Uptake of Interventions from a Probability Survey
AID  - 10.1158/1055-9965.EPI-14-1333
DP  - 2015 May 01
TA  - Cancer Epidemiology Biomarkers & Prevention
PG  - 842--853
VI  - 24
IP  - 5
4099  - http://cebp.aacrjournals.org/content/24/5/842.short
4100  - http://cebp.aacrjournals.org/content/24/5/842.full
SO  - Cancer Epidemiol Biomarkers Prev2015 May 01; 24
AB  - Background: The third British National Survey of Sexual Attitudes and Lifestyles (Natsal-3) provides an opportunity to explore high-risk human papillomavirus (HR-HPV) and uptake of cervical screening and HPV vaccination in the general population. Methods: Natsal-3, a probability sample survey of men and women ages 16 to 74, resident in Britain, interviewed 8,869 women in 2010 to 2012. We explored risk factors for HR-HPV (in urine from 2,569 sexually experienced women ages 16 to 44), nonattendance for cervical screening in the past 5 years, and noncompletion of HPV catch-up vaccination. Results: HR-HPV was associated with increasing numbers of lifetime partners, younger age, increasing area-level deprivation, and smoking. Screening nonattendance was associated with younger and older age, increasing area-level deprivation (age-adjusted OR 1.91, 95% confidence interval, 1.48–2.47 for living in most vs. least deprived two quintiles), Asian/Asian British ethnicity (1.96, 1.32–2.90), smoking (1.97, 1.57–2.47), and reporting no partner in the past 5 years (2.45, 1.67–3.61 vs. 1 partner) but not with HR-HPV (1.35, 0.79–2.31). Lower uptake of HPV catch-up vaccination was associated with increasing area-level deprivation, non-white ethnicity, smoking, and increasing lifetime partners. Conclusions: Socioeconomic markers and smoking were associated with HR-HPV positivity, nonattendance for cervical screening, and noncompletion of catch-up HPV vaccination. Impact: The cervical screening program needs to engage those missing HPV catch-up vaccination to avoid a potential widening of cervical cancer disparities in these cohorts. As some screening nonattenders are at low risk for HR-HPV, tailored approaches may be appropriate to increase screening among higher-risk women. Cancer Epidemiol Biomarkers Prev; 24(5); 842–53. ©2015 AACR.