PT  - JOURNAL ARTICLE
AU  - Liu, Mengfei
AU  - He, Zhonghu
AU  - Zhang, Chanyuan
AU  - Liu, Fangfang
AU  - Liu, Ying
AU  - Li, Jingjing
AU  - Xu, Zhongyao
AU  - Wang, Qiyan
AU  - Hang, Dong
AU  - Shen, Na
AU  - Pan, Yaqi
AU  - Guo, Chuanhai
AU  - Cai, Hong
AU  - Ke, Yang
TI  - Prevalence, Incidence, Clearance, and Associated Factors of Genital Human Papillomavirus Infection among Men: A Population-Based Cohort Study in Rural China
AID  - 10.1158/1055-9965.EPI-14-0365
DP  - 2014 Dec 01
TA  - Cancer Epidemiology Biomarkers & Prevention
PG  - 2857--2865
VI  - 23
IP  - 12
4099  - http://cebp.aacrjournals.org/content/23/12/2857.short
4100  - http://cebp.aacrjournals.org/content/23/12/2857.full
SO  - Cancer Epidemiol Biomarkers Prev2014 Dec 01; 23
AB  - Background: The natural history of human papillomavirus (HPV) infection in men on a population base has rarely been studied in general, particularly among Chinese men. Methods: A total of 1,286 men ages 25 to 65 years from rural China were enrolled during 2009–2010 and their genital HPV infection status was assessed biannually for up to seven visits using PCR and sequencing methods. Prevalence analysis was performed among men with at least one valid HPV result (N = 1,279) and men with at least two consecutive HPV results (N = 1,059) were included in incidence and clearance analyses (median follow-up time, 31.8 months; interquartile range, 15.4–37.9 months). Results: The prevalence and incidence of any HPV type, oncogenic, and nononcogenic HPV were 17.8%, 6.4%, 12.4%, and 14.6, 4.9, 10.8 per 1,000 person months, respectively. The median duration of infection with any HPV type, oncogenic, and nononcogenic HPV was 11.5, 6.8, and 11.5 months, respectively. The number of lifetime sexual partners was consistently associated with increased risk of prevalent and incident infection of HPV. Men ages 25 to 50 years had a higher incidence and longer duration of HPV infection than older men (51–65 years). Conclusions and Impact: This epidemiologic investigation provides basic information of genital HPV infection among the Chinese male population; these data are crucial for the consideration of primary strategies against HPV-related carcinoma in the Chinese male and female population. Cancer Epidemiol Biomarkers Prev; 23(12); 2857–65. ©2014 AACR.