RT Journal Article
SR Electronic
T1 No Evidence of Gene–Calcium Interactions from Genome-Wide Analysis of Colorectal Cancer Risk
JF Cancer Epidemiology Biomarkers & Prevention
JO Cancer Epidemiol Biomarkers Prev
FD American Association for Cancer Research
SP 2971
OP 2976
DO 10.1158/1055-9965.EPI-14-0893
VO 23
IS 12
A1 Du, Mengmeng
A1 Zhang, Xuehong
A1 Hoffmeister, Michael
A1 Schoen, Robert E.
A1 Baron, John A.
A1 Berndt, Sonja I.
A1 Brenner, Hermann
A1 Carlson, Christopher S.
A1 Casey, Graham
A1 Chan, Andrew T.
A1 Curtis, Keith R.
A1 Duggan, David
A1 Gauderman, W. James
A1 Giovannucci, Edward L.
A1 Gong, Jian
A1 Harrison, Tabitha A.
A1 Hayes, Richard B.
A1 Henderson, Brian E.
A1 Hopper, John L.
A1 Hsu, Li
A1 Hudson, Thomas J.
A1 Hutter, Carolyn M.
A1 Jenkins, Mark A.
A1 Jiao, Shuo
A1 Kocarnik, Jonathan M.
A1 Kolonel, Laurence N.
A1 Le Marchand, Loic
A1 Lin, Yi
A1 Newcomb, Polly A.
A1 Rudolph, Anja
A1 Seminara, Daniela
A1 Thornquist, Mark D.
A1 Ulrich, Cornelia M.
A1 White, Emily
A1 Wu, Kana
A1 Zanke, Brent W.
A1 Campbell, Peter T.
A1 Slattery, Martha L.
A1 Peters, Ulrike
A1 Chang-Claude, Jenny
A1 Potter, John D.
YR 2014
UL http://cebp.aacrjournals.org/content/23/12/2971.abstract
AB Background: Calcium intake may reduce risk of colorectal cancer, but the mechanisms remain unclear. Studies of interaction between calcium intake and SNPs in calcium-related pathways have yielded inconsistent results. Methods: To identify gene–calcium interactions, we tested interactions between approximately 2.7 million SNPs across the genome with self-reported calcium intake (from dietary or supplemental sources) in 9,006 colorectal cancer cases and 9,503 controls of European ancestry. To test for multiplicative interactions, we used multivariable logistic regression and defined statistical significance using the conventional genome-wide α = 5E−08. Results: After accounting for multiple comparisons, there were no statistically significant SNP interactions with total, dietary, or supplemental calcium intake. Conclusions: We found no evidence of SNP interactions with calcium intake for colorectal cancer risk in a large population of 18,509 individuals. Impact: These results suggest that in genome-wide analysis common genetic variants do not strongly modify the association between calcium intake and colorectal cancer in European populations. Cancer Epidemiol Biomarkers Prev; 23(12); 2971–6. ©2014 AACR.