PT  - JOURNAL ARTICLE
AU  - Mavaddat, Nasim
AU  - Barrowdale, Daniel
AU  - Andrulis, Irene L.
AU  - Domchek, Susan M.
AU  - Eccles, Diana
AU  - Nevanlinna, Heli
AU  - Ramus, Susan J.
AU  - Spurdle, Amanda
AU  - Robson, Mark
AU  - Sherman, Mark
AU  - Mulligan, Anna Marie
AU  - Couch, Fergus J.
AU  - Engel, Christoph
AU  - McGuffog, Lesley
AU  - Healey, Sue
AU  - Sinilnikova, Olga M.
AU  - Southey, Melissa C.
AU  - Terry, Mary Beth
AU  - Goldgar, David
AU  - O'Malley, Frances
AU  - John, Esther M.
AU  - Janavicius, Ramunas
AU  - Tihomirova, Laima
AU  - Hansen, Thomas V. O.
AU  - Nielsen, Finn C.
AU  - Osorio, Ana
AU  - Stavropoulou, Alexandra
AU  - Benítez, Javier
AU  - Manoukian, Siranoush
AU  - Peissel, Bernard
AU  - Barile, Monica
AU  - Volorio, Sara
AU  - Pasini, Barbara
AU  - Dolcetti, Riccardo
AU  - Putignano, Anna Laura
AU  - Ottini, Laura
AU  - Radice, Paolo
AU  - Hamann, Ute
AU  - Rashid, Muhammad U.
AU  - Hogervorst, Frans B.
AU  - Kriege, Mieke
AU  - van der Luijt, Rob B.
AU  - Peock, Susan
AU  - Frost, Debra
AU  - Evans, D. Gareth
AU  - Brewer, Carole
AU  - Walker, Lisa
AU  - Rogers, Mark T.
AU  - Side, Lucy E.
AU  - Houghton, Catherine
AU  - Weaver, JoEllen
AU  - Godwin, Andrew K.
AU  - Schmutzler, Rita K.
AU  - Wappenschmidt, Barbara
AU  - Meindl, Alfons
AU  - Kast, Karin
AU  - Arnold, Norbert
AU  - Niederacher, Dieter
AU  - Sutter, Christian
AU  - Deissler, Helmut
AU  - Gadzicki, Doroteha
AU  - Preisler-Adams, Sabine
AU  - Varon-Mateeva, Raymonda
AU  - Schönbuchner, Ines
AU  - Gevensleben, Heidrun
AU  - Stoppa-Lyonnet, Dominique
AU  - Belotti, Muriel
AU  - Barjhoux, Laure
AU  - Isaacs, Claudine
AU  - Peshkin, Beth N.
AU  - Caldes, Trinidad
AU  - de la Hoya, Miguel
AU  - Cañadas, Carmen
AU  - Heikkinen, Tuomas
AU  - Heikkilä, Päivi
AU  - Aittomäki, Kristiina
AU  - Blanco, Ignacio
AU  - Lazaro, Conxi
AU  - Brunet, Joan
AU  - Agnarsson, Bjarni A.
AU  - Arason, Adalgeir
AU  - Barkardottir, Rosa B.
AU  - Dumont, Martine
AU  - Simard, Jacques
AU  - Montagna, Marco
AU  - Agata, Simona
AU  - D'Andrea, Emma
AU  - Yan, Max
AU  - Fox, Stephen
AU  - Rebbeck, Timothy R.
AU  - Rubinstein, Wendy
AU  - Tung, Nadine
AU  - Garber, Judy E.
AU  - Wang, Xianshu
AU  - Fredericksen, Zachary
AU  - Pankratz, Vernon S.
AU  - Lindor, Noralane M.
AU  - Szabo, Csilla
AU  - Offit, Kenneth
AU  - Sakr, Rita
AU  - Gaudet, Mia M.
AU  - Singer, Christian F.
AU  - Tea, Muy-Kheng
AU  - Rappaport, Christine
AU  - Mai, Phuong L.
AU  - Greene, Mark H.
AU  - Sokolenko, Anna
AU  - Imyanitov, Evgeny
AU  - Toland, Amanda Ewart
AU  - Senter, Leigha
AU  - Sweet, Kevin
AU  - Thomassen, Mads
AU  - Gerdes, Anne-Marie
AU  - Kruse, Torben
AU  - Caligo, Maria
AU  - Aretini, Paolo
AU  - Rantala, Johanna
AU  - von Wachenfeld, Anna
AU  - Henriksson, Karin
AU  - Steele, Linda
AU  - Neuhausen, Susan L.
AU  - Nussbaum, Robert
AU  - Beattie, Mary
AU  - Odunsi, Kunle
AU  - Sucheston, Lara
AU  - Gayther, Simon A.
AU  - Nathanson, Kate
AU  - Gross, Jenny
AU  - Walsh, Christine
AU  - Karlan, Beth
AU  - Chenevix-Trench, Georgia
AU  - Easton, Douglas F.
AU  - Antoniou, Antonis C.
TI  - Pathology of Breast and Ovarian Cancers among <em>BRCA1</em> and <em>BRCA2</em> Mutation Carriers: Results from the Consortium of Investigators of Modifiers of <em>BRCA1</em>/<em>2</em> (CIMBA)
AID  - 10.1158/1055-9965.EPI-11-0775
DP  - 2012 Jan 01
TA  - Cancer Epidemiology Biomarkers & Prevention
PG  - 134--147
VI  - 21
IP  - 1
4099  - http://cebp.aacrjournals.org/content/21/1/134.short
4100  - http://cebp.aacrjournals.org/content/21/1/134.full
SO  - Cancer Epidemiol Biomarkers Prev2012 Jan 01; 21
AB  - Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors differ in their pathology. Analysis of larger datasets of mutation carriers should allow further tumor characterization. Methods: We used data from 4,325 BRCA1 and 2,568 BRCA2 mutation carriers to analyze the pathology of invasive breast, ovarian, and contralateral breast cancers. Results: There was strong evidence that the proportion of estrogen receptor (ER)-negative breast tumors decreased with age at diagnosis among BRCA1 (P-trend = 1.2 × 10−5), but increased with age at diagnosis among BRCA2, carriers (P-trend = 6.8 × 10−6). The proportion of triple-negative tumors decreased with age at diagnosis in BRCA1 carriers but increased with age at diagnosis of BRCA2 carriers. In both BRCA1 and BRCA2 carriers, ER-negative tumors were of higher histologic grade than ER-positive tumors (grade 3 vs. grade 1; P = 1.2 × 10−13 for BRCA1 and P = 0.001 for BRCA2). ER and progesterone receptor (PR) expression were independently associated with mutation carrier status [ER-positive odds ratio (OR) for BRCA2 = 9.4, 95% CI: 7.0–12.6 and PR-positive OR = 1.7, 95% CI: 1.3–2.3, under joint analysis]. Lobular tumors were more likely to be BRCA2-related (OR for BRCA2 = 3.3, 95% CI: 2.4–4.4; P = 4.4 × 10−14), and medullary tumors BRCA1-related (OR for BRCA2 = 0.25, 95% CI: 0.18–0.35; P = 2.3 × 10−15). ER-status of the first breast cancer was predictive of ER-status of asynchronous contralateral breast cancer (P = 0.0004 for BRCA1; P = 0.002 for BRCA2). There were no significant differences in ovarian cancer morphology between BRCA1 and BRCA2 carriers (serous: 67%; mucinous: 1%; endometrioid: 12%; clear-cell: 2%). Conclusions/Impact: Pathologic characteristics of BRCA1 and BRCA2 tumors may be useful for improving risk-prediction algorithms and informing clinical strategies for screening and prophylaxis. Cancer Epidemiol Biomarkers Prev; 21(1); 134–47. ©2011 AACR.