PT  - JOURNAL ARTICLE
AU  - Eduardo De Stéfani, 
AU  - Deneo-Pellegrini, Hugo
AU  - Boffetta, Paolo
AU  - Ronco, Alvaro
AU  - Mendilaharsu, María
TI  - α-Linolenic Acid and Risk of Prostate Cancer: A Case-Control Study in Uruguay
DP  - 2000 Mar 01
TA  - Cancer Epidemiology Biomarkers & Prevention
PG  - 335--338
VI  - 9
IP  - 3
4099  - http://cebp.aacrjournals.org/content/9/3/335.short
4100  - http://cebp.aacrjournals.org/content/9/3/335.full
SO  - Cancer Epidemiol Biomarkers Prev2000 Mar 01; 9
AB  - In the time period of 1994–1998, a case-control study on diet and prostate cancer was carried out in Uruguay to examine the risk associated with fat intake. Two hundred and seventeen (217) incident cases afflicted with advanced prostate cancer were frequency-matched with 431 controls on age, residence, and urban/rural status. The analysis was carried out using unconditional multiple logistic regression. α-Linolenic acid was associated with a strong positive association (fourth quartile of intake odds ratio, 3.91; 95% confidence interval, 1.50–10.1) after controlling for total calorie intake and for the other types of fat. The effect was similar whenα -linolenic acid was analyzed by its sources of origin (odds ratio for vegetable linolenic acid, 2.03; 95% confidence interval, 1.01–4.07). Including this report, five of six studies that have examined the relationship between α-linolenic acid and prostate cancer yielded a positive association, which was significant in four studies. Thus, there appears to be evidence of a role of α-linolenic acid in prostate carcinogenesis.