RT Journal Article
SR Electronic
T1 Meat intake, heterocyclic amines, and risk of breast cancer: a case-control study in Uruguay.
JF Cancer Epidemiology Biomarkers & Prevention
JO Cancer Epidemiol Biomarkers Prev
FD American Association for Cancer Research
SP 573
OP 581
VO 6
IS 8
A1 De Stefani, E
A1 Ronco, A
A1 Mendilaharsu, M
A1 Guidobono, M
A1 Deneo-Pellegrini, H
YR 1997
UL http://cebp.aacrjournals.org/content/6/8/573.abstract
AB To study the effects of meat intake, including heterocyclic amine exposure, on the risk of breast cancer, we conducted a hospital-based case-control study involving 352 patients with breast cancer and 382 controls. A strong effect of red meat, total meat, beef, fried meat, and heterocyclic amine exposure was found, after controlling for potential confounders. The odds ratio for the highest quartile of 2-amino-3-methylimidazo [4,5-f]quinoline exposure was 3.34 (95% confidence interval 1.85-6.02). According to these results, meat intake and chemicals formed during the cooking process appear to be strong risk factors in human breast carcinogenesis.