PT  - JOURNAL ARTICLE
AU  - Rinaldi, Sabina
AU  - Rohrmann, Sabine
AU  - Jenab, Mazda
AU  - Biessy, Carine
AU  - Sieri, Sabina
AU  - Palli, Domenico
AU  - Tumino, Rosario
AU  - Mattiello, Amalla
AU  - Vineis, Paolo
AU  - Nieters, Alexandra
AU  - Linseisen, Jakob
AU  - Pischon, Tobias
AU  - Boeing, Heiner
AU  - Hallmans, Göran
AU  - Palmqvist, Richard
AU  - Manjer, Jonas
AU  - Wirfält, Elisabet
AU  - Crowe, Francesca L.
AU  - Khaw, Kay-Tee T.
AU  - Bingham, Sheila
AU  - Tjønneland, Anne
AU  - Olsen, Anja
AU  - Overvad, Kim
AU  - Lund, Eiliv
AU  - Skeie, Guri
AU  - Clavel-Chapelon, Francoise
AU  - Boutron-Ruault, Marie-Christine
AU  - de Lauzon-Guillain, Blandine
AU  - Ardanaz, Eva
AU  - Jakszyn, Paula
AU  - Ramon Quiros, Jose
AU  - Chirlaque, Maria-Dolores
AU  - Sanchez, Maria-Jose
AU  - Dorronsoro, Miren
AU  - Trichopoulou, Antonia
AU  - Lagiou, Pagona
AU  - Trichopoulos, Dimitrious
AU  - Bueno-de-Mesquita, H. Bas
AU  - van Duijnhoven, Fränzel J.B.
AU  - Peeters, Petra H.M.
AU  - Slimani, Nadia
AU  - Ferrari, Pietro
AU  - Byrnes, Graham B.
AU  - Riboli, Elio
AU  - Kaaks, Rudolf
TI  - Glycosylated Hemoglobin and Risk of Colorectal Cancer in Men and Women, the European Prospective Investigation into Cancer and Nutrition
AID  - 10.1158/1055-9965.EPI-08-0495
DP  - 2008 Nov 01
TA  - Cancer Epidemiology Biomarkers & Prevention
PG  - 3108--3115
VI  - 17
IP  - 11
4099  - http://cebp.aacrjournals.org/content/17/11/3108.short
4100  - http://cebp.aacrjournals.org/content/17/11/3108.full
SO  - Cancer Epidemiol Biomarkers Prev2008 Nov 01; 17
AB  - Although large-scale prospective cohort studies have related hyperglycemia to increased risk of cancer overall, studies specifically on colorectal cancer have been generally small. We investigated the association between prediagnostic levels of glycosylated hemoglobin (HbA1c), a marker for average glucose level in blood, and colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort. One thousand and twenty-six incident colorectal cancer cases (561 men and 465 women) and 1,026 matched controls were eligible for the study. Multivariate conditional logistic regression was used to estimate odds ratios (ORS) adjusted for possible confounders. Increasing HbA1c percentages were statistically significantly associated with a mild increase in colorectal cancer risk in the whole population [OR, 1.10; 95% confidence interval (CI), 1.01,1.19 for a 10% increase in HbA1c]. In women, increasing HbA1c percentages were associated with a statistically significant increase in colorectal cancer risk (OR, 1.16; 95% CI, 1.01, 1.32 for a 10% increase in HbA1c) and with a borderline statistically significant increase in rectum cancer (OR, 1.22; 95% CI, 0.99,1.50 for a 10% increase in HbA1c). No significant association with cancer risk was observed in men. The results of the current study suggest a mild implication of hyperglycemia in colorectal cancer, which seems more important in women than in men, and more for cancer of the rectum than of the colon. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3108–15)