RT Journal Article SR Electronic T1 Associations of Mammographic Density with Dietary Factors in Japanese Women JF Cancer Epidemiology Biomarkers & Prevention JO Cancer Epidemiol Biomarkers Prev FD American Association for Cancer Research SP 2877 OP 2880 DO 10.1158/1055-9965.EPI-05-0160 VO 14 IS 12 A1 Nagata, Chisato A1 Matsubara, Tomoko A1 Fujita, Hiroshi A1 Nagao, Yasuko A1 Shibuya, Chiken A1 Kashiki, Yoshitomo A1 Shimizu, Hiroyuki YR 2005 UL http://cebp.aacrjournals.org/content/14/12/2877.abstract AB Background: A high percentage of mammographic dense area has been strongly associated with a risk of beast cancer. The present cross-sectional study evaluated the relations of percent density with dietary factors, such as fats, protein, dietary fiber, and soy isoflavones. Methods: Study subjects were 601 (348 premenopausal and 253 postmenopausal) Japanese women who were recruited from a mammographic screening center. The size of the total breast area and the dense area were measured quantitatively using an automated mammographic mass detection method. Intakes of nutrients were estimated with a validated semiquantitative food-frequency questionnaire. Results: The crude means of the percent density were 39.2% and 18.9% in premenopausal and postmenopausal women, respectively. There were no significant associations of any dietary factors with the percent density in premenopausal women. In postmenopausal women, percent density was significantly positively associated with intakes of protein, total fat, and saturated fat after controlling for covariates; the increase in the means of percent density were 7.2%, 5.6%, and 9.2% in the highest versus lowest quartile of intakes for protein, total fat, and saturated fat, respectively (P for linear trend were 0.006, 0.04, and 0.01, respectively). Carbohydrate intake was inversely associated with percent density; the mean of percent density was 6.0% lower in the highest versus the lowest quartile of intake (Ptrend = 0.03). The associations of dietary factors with dense area were very similar to those with percent density. Conclusion: These dietary factors may have implications for the risk of breast cancer in postmenopausal women. (Cancer Epidemiol Biomarkers Prev 2005;14(12):2877–80)