PT  - JOURNAL ARTICLE
AU  - Ferreccio, Catterina
AU  - Prado, Rodrigo B.
AU  - Luzoro, Amaranta V.
AU  - Ampuero, Sandra Ll.
AU  - Snijders, Peter J.F.
AU  - Meijer, Chris J.L.M.
AU  - Vaccarella, Salvatore V.
AU  - Jara, Alejandro T.
AU  - Puschel, Klaus I.
AU  - Robles, Sylvia C.
AU  - Herrero, Rolando
AU  - Franceschi, Silvia F.
AU  - Ojeda, Jose M.
TI  - Population-Based Prevalence and Age Distribution of Human Papillomavirus Among Women in Santiago, Chile
DP  - 2004 Dec 01
TA  - Cancer Epidemiology Biomarkers & Prevention
PG  - 2271--2276
VI  - 13
IP  - 12
4099  - http://cebp.aacrjournals.org/content/13/12/2271.short
4100  - http://cebp.aacrjournals.org/content/13/12/2271.full
SO  - Cancer Epidemiol Biomarkers Prev2004 Dec 01; 13
AB  - More than 18 types of human papillomavirus (HPV) are associated with cervical cancer, the relative importance of the HPV types may vary in different populations. Objective: To investigate the types of HPV, age distribution, and risk factors for HPV infection in women from Santiago, Chile. Methods: We interviewed and obtained two cervical specimens from a population-based random sample of 1,038 sexually active women (age range, 15-69 years). Specimens were tested for the presence of HPV DNA using a GP5+/6+ primer-mediated PCR and for cervical cytologic abnormalities by Papanicolaou smears. Results: 122 women tested positive for HPV DNA, 87 with high risk types (HR), and 35 with low risks (LR) only. Standardized prevalence of HPV DNA was 14.0% [95% confidence interval (95% CI), 11.5-16.4]. HR HPV by age showed a J reverse curve, whereas LR HPV showed a U curve, both statistically significant in comparison with no effect or with a linear effect. We found 34 HPV types (13 HR and 21 LR); HPV 16, 56, 31, 58, 59, 18, and 52 accounted for 75.4% of HR infections. Thirty-four (3.6%) women had cytologic lesions. Main risk factor for HPV and for cytologic abnormalities was number of lifetime sexual partners, odds ratios for ≥3 versus 1 were 2.8 (95% CI, 1.6-5.0) and 3.8 (95% CI, 1.3-11.4), respectively. Conclusions: LR HPV presented a clear bimodal age pattern; HR HPV presented a J reverse curve. HPV prevalence was similar to that described in most Latin American countries.