RT Journal Article
SR Electronic
T1 European Ancestry Is Positively Associated with Breast Cancer Risk in Mexican Women
JF Cancer Epidemiology Biomarkers & Prevention
JO Cancer Epidemiol Biomarkers Prev
FD American Association for Cancer Research
SP 1074
OP 1082
DO 10.1158/1055-9965.EPI-09-1193
VO 19
IS 4
A1 Fejerman, Laura
A1 Romieu, Isabelle
A1 John, Esther M.
A1 Lazcano-Ponce, Eduardo
A1 Huntsman, Scott
A1 Beckman, Kenneth B.
A1 Pérez-Stable, Eliseo J.
A1 González Burchard, Esteban
A1 Ziv, Elad
A1 Torres-Mejía, Gabriela
YR 2010
UL http://cebp.aacrjournals.org/content/19/4/1074.abstract
AB The incidence of breast cancer is 35% lower in Hispanic women living in the San Francisco Bay Area than in non-Hispanic White women. We have previously described a significant association between genetic ancestry and risk for breast cancer in a sample of U.S. Hispanics/Latinas. We retested the association in women residing in Mexico because of the possibility that the original finding may be confounded by U.S. specific unmeasured environmental exposures. We genotyped a set of 106 ancestry informative markers in 846 Mexican women with breast cancer and 1,035 unaffected controls and estimated genetic ancestry using a maximum likelihood method. Odds ratios and 95% confidence intervals (95% CI) for ancestry modeled as a categorical and continuous variable were estimated using logistic regression and adjusted for reproductive and other known risk factors. Greater European ancestry was associated with increased breast cancer risk in this new and independent sample of Mexican women residing in Mexico. Compared with women with 0% to 25% European ancestry, the risk was increased for women with 51% to 75% and 76% to 100% European ancestry [odds ratios, 1.35 (95% CI, 0.96-1.91) and 2.44 (95% CI, 0.94-6.35), respectively; P for trend = 0.044]. For every 25% increase in European ancestry (modeled as a continuous variable), there was a 20% increase in risk for breast cancer (95% CI, 1.03-1.41; P = 0.019). These results suggest that nongenetic factors play a crucial role in explaining the difference in breast cancer incidence between Latinas and non-Latina White women, and it also points out to the possibility of a genetic component to this difference. Cancer Epidemiol Biomarkers Prev; 19(4); 1074–82. ©2010 AACR.