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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Association between gene promoter methylation and cervical cancer development: global distribution and a meta-analysis

Aissam El Aliani, Hassan El Abid, Yassine El Mallali, Mohammed Attaleb, Moulay Mustapha Ennaji and Mohammed El Mzibri
Aissam El Aliani
1Biology, Faculty of Sciences and Techniques of Mohammedia (FSTM), University of Hassan II of Casablanca.
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Hassan El Abid
2Biology, Faculty of Sciences, Moulay Ismail University
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Yassine El Mallali
1Biology, Faculty of Sciences and Techniques of Mohammedia (FSTM), University of Hassan II of Casablanca.
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  • ORCID record for Yassine El Mallali
Mohammed Attaleb
3Centre National de l'Energie des Sciences et des Techniques Nucléaires
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Moulay Mustapha Ennaji
4Biology, Faculty of Science and Technology. University Hassan II-Mohammedia.
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Mohammed El Mzibri
5Life sciences, Centre National de l'Energie, des Sciences et des Techniques Nucléaires (CNESTEN)
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  • For correspondence: elmzibri@gmail.com
DOI: 10.1158/1055-9965.EPI-20-0833
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Abstract

DNA methylation is the main epigenetic event for gene silencing and is associated with carcinogenesis. In this meta-analysis, we evaluated the association between the methylation of the promoter regions of APC, CADM1, CCNA1, CDH1, DAPK, FHIT, HIC1, MAL, MGMT, hMLH1, p16, PAX1, RAR-β, and RASSF1 genes and the risk of cervical cancer development and progression. Overall, 194 eligible studies were identified assessing the associations of APC, CADM1, CCNA1, CDH1, DAPK, FHIT, HIC1, MAL, MGMT, hMLH1, p16, PAX1, RAR-β and RASSF1 promoters methylation status with LSIL, HSIL and cervical cancer development. Almost studies were conducted on Caucasian and Asian populations whereas limited data are available from African population. Promoters methylation frequencies were shown to be significantly higher in LSIL, HSIL cervical cancer cases as compared to control specimens for CADM1, CCNA1, CDH1, DAPK1, FHIT, MAL, P16, PAX1, RAR-β, and RASSF1 genes. A moderate association was found between HIC promoter methylation whereas APC, MGMT, and hMLH1 promoters' methylation was not correlated with cervical cancer development. Promoters methylation could be considered as a non-invasive biomarker for early cervical lesions, making them highly promising targets for a personalized therapeutic approach.

  • Received June 18, 2020.
  • Revision received September 27, 2020.
  • Accepted December 31, 2020.
  • Copyright ©2021, American Association for Cancer Research.

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This OnlineFirst version was published on January 13, 2021
doi: 10.1158/1055-9965.EPI-20-0833

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Association between gene promoter methylation and cervical cancer development: global distribution and a meta-analysis
Aissam El Aliani, Hassan El Abid, Yassine El Mallali, Mohammed Attaleb, Moulay Mustapha Ennaji and Mohammed El Mzibri
Cancer Epidemiol Biomarkers Prev January 13 2021 DOI: 10.1158/1055-9965.EPI-20-0833

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Association between gene promoter methylation and cervical cancer development: global distribution and a meta-analysis
Aissam El Aliani, Hassan El Abid, Yassine El Mallali, Mohammed Attaleb, Moulay Mustapha Ennaji and Mohammed El Mzibri
Cancer Epidemiol Biomarkers Prev January 13 2021 DOI: 10.1158/1055-9965.EPI-20-0833
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Cancer Epidemiology, Biomarkers & Prevention
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