Article Figures & Data
Tables
- Table 1
Comparative results of four H. pylori assays using different antigens
Antigen Prevalence ORa (95% CI) Controls Cases Dutch strains 83 /119 (70%) 80 /117 (68%) 0.77 (0.41–1.44) Venezuelan strains 101 /115 (88%) 91 /104 (88%) 0.95 (0.42–2.2) French strains 111 /115 (97%) 87 /104 (84%) 0.18 (0.05–0.51) Commercial kit 160 /173 (92%) 162 /172 (94%) 1.25 (0.55–2.92) -
a OR have been adjusted for age and sex.
-
- Table 2
Quartiles of the ELISA index distribution among controls
Antigen Lower quartile Median Upper quartile Cutoff Dutch strains 0.62 0.90 1.05 0.65 Venezuelan strains 0.49 0.83 1.05 0.21 French strains 0.39 0.77 1.09 0.21 Commercial kit 95.5 275.5 >300a 20 -
a Upper quartile is not known because values >300 are censored.
-
- Table 3
ORs (95% CIs) for stomach cancer by quartiles of antibody titer, controlling for age and sex
H. pylori antigen OR by quartile group (95% CI) P for trend Q1 Q2 Q3 Q4 Dutch strains 1.0 1.31 (0.61–2.80) 0.51 (0.22–1.19) 0.31 (0.12–0.78) 0.003 Venezuelan strains 1.0 1.10 (0.53–2.27) 0.64 (0.30–1.38) 0.64 (0.29–1.39) 0.13 French strains 1.0 1.05 (0.51–2.15) 0.47 (0.22–1.01) 0.24 (0.10–0.59) 0.0004 Commercial kit 1.0 1.61 (0.90–2.90) 0.79a (0.46–1.38) 0.14 -
a The upper two quartile groups were merged for the commercial kit because of the large number of subjects with ELISA indices >300, which were censored.
-
- Table 4
Spearman’s rank correlations between the absorbance values of four H. pylori assays
Correlations Dutch Venezuelan French Commercial Dutch strains 1.00 0.78 0.70 0.78 Venezuelan strains 1.00 0.71 0.68 French strains 1.00 0.58 Commercial kit 1.00 - Table 5
H. pylori prevalence among cases by histological type and location of gastric cancer
H. pylori antigen H. pylori prevalence P Intestinal type Diffuse type Dutch strains 41/61 (67%) 27/40 (68%) 1.00 French strains 46/57 (81%) 30/34 (88%) 0.52 Venezuelan strains 51/57 (89%) 29/34 (85%) 0.80 Commercial kit 82/88 (93%) 47/50 (94%) 0.86 Cardia Noncardia Dutch strains 9/13 (69%) 69/100 (69%) 1.00 French strains 9/11 (82%) 80/90 (89%) 0.61 Venezuelan strains 9/11 (82%) 76/90 (84%) 0.69 Commercial kit 22/22 (100%) 129/137 (94%) 0.60 - Table 6
Subgroup analysis of relationship between antibody titre and gastric cancer by pepsinogen levels
Antigen Normal (PGI:PGII >3.0) Low (PGI:PGII <3.0) Interaction P ORa 95% CI P ORa 95% CI P Dutch strains 0.69 (0.20–2.34) 0.55 0.13 (0.03–0.48) 0.002 0.05 French strains 1.06 (0.30–3.80) 0.93 0.28 (0.09–0.90) 0.03 0.08 Venezuelan strains 0.93 (0.25–3.38) 0.91 0.31 (0.10–0.97) 0.04 0.46 Commercial kit 1.09 (0.51–2.33) 0.83 0.31 (0.14–0.68) 0.003 0.02 CagA 1.09 (0.48–2.48) 0.84 0.19 (0.08–0.47) 0.003 0.002 -
a OR between top and bottom quartile groups (baseline = bottom) according to a trend model, controlling for age and sex.
-
- Table 7
Cases only: H. pylori antibody titres by cancer stage
Antigen and cancer stage Quartile group ORa (95% CI) P Q1 Q2 Q3 Q4 Dutch strains Early 4 6 13 10 0.007 0.19 (0.06–0.65) Late 24 17 10 13 French strains Early 4 5 13 10 0.009 0.17 (0.04–0.63) Late 18 14 12 10 Venezuelan strains Early 5 8 9 10 0.05 0.28 (0.08–0.97) Late 20 11 14 9 Commercial kit Early 4 6 5 14 0.01 0.21 (0.06–0.72) Late 30 28 23 25 CagA Early 5 11 8 15 0.04 0.36 (0.14–0.95) Late 54 47 51 45 -
a OR between top and bottom quartile groups (baseline = Q1) according to a trend model, controlling for age and sex.
-
Volume 9, Issue 9
