Article Figures & Data
Figures
- Fig. 1.
Plot of the relationship between baseline rectal mucosal PGE2 content and BMI. The baseline rectal mucosal PGE2 content was an average of the data collected before and at the end of the run-in period. ——, a regression fit of the data (Y = 12.5 × X − 103.2; r2= 0.269; P = 0.007) without the inclusion of the data point in parentheses.
- Fig. 2.
Plot of the rectal mucosal PGE2 content in each individual subject before and after placebo/ibuprofen treatment. ∗, the data after 4 weeks of ibuprofen treatment were not available.
Tables
- Table 1
Demographic data of the study participants
Placebo Ibuprofen 300 mg/day Ibuprofen 600 mg/day No. of subjects 9 9 9 No. of present smokers 1 1 1 No. of females 4 4 3 Age (year) 58 ± 13a 59 ± 10 62 ± 5 (39–73)b (39–70) (54–69) Height (cm) 167 ± 16 171 ± 11 172 ± 7 (134–188) (161–190) (161–180) Weight (kg) 88 ± 28 87 ± 24 83 ± 9 (64–152) (58–121) (65–96) BMI (kg/m2) 31.7 ± 8.2 29.6 ± 7.8 28.3 ± 3.9 (23–49) (21–44) (20–31) -
a Mean ± 1 SD.
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b Data range.
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- Table 2
Mean plasma ibuprofen levels (μg/ml) before and after daily ibuprofen treatment
Ibuprofen dose (mg/day) Before the placebo run-in period At the end of the placebo run-in period After 2 wk of ibuprofen treatment After 4 wk of ibuprofen treatment 0 (placebo) 0 ± 0 0 ± 0 0 ± 0 0 ± 0 300 0 ± 0 0 ± 0 12.7 ± 4.5 13.3 ± 3.2 600 0.17 ± 0.52a 0.20 ± 0.60a 21.1 ± 6.1b 26.3 ± 8.0b -
a Resulted from ibuprofen levels seen in one individual.
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b Significantly different from subjects taking 300 mg/day ibuprofen; P < 0.05.
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- Table 3
Mean rectal mucosal PGE2 content (pg/mg protein) before and after ibuprofen treatment
Ibuprofen dose (mg/day) Averaged baseline (before and at the end of the run-in period) After 2 wk of treatment After 4 wk of treatment 0 (placebo) 394.7 ± 221.8 257.4 ± 180.9 178.2 ± 91.5 300 237.9 ± 128.6 100.2 ± 91.5 98.6 ± 41.4 600 215.6 ± 123.8 133.1 ± 123.9 115.1 ± 160.8 - Table 4
The PGE2 levels after 2 or 4 weeks of ibuprofen/placebo treatment, expressed as percent of the baseline values (100 × ((PGE2)posttreatment/(PGE2)baseline))
Ibuprofen dose (mg/day) After 2 wk of treatment After 4 wk of treatment 0 (placebo) 78 ± 52 69 ± 78 300 45 ± 30a 51 ± 28 600 59 ± 26 60 ± 46 -
a Changes in logarithmically transformed PGE2 levels were significantly different from those after placebo treatment (see data analysis section for details); P = 0.033.
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Volume 9, Issue 4
