Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Progress and Priorities
    • Collections
      • COVID-19 & Cancer Resource Center
      • Disparities Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Informing Public Health Policy
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Progress and Priorities
    • Collections
      • COVID-19 & Cancer Resource Center
      • Disparities Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Informing Public Health Policy
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Research Articles

A Prospective Study of Plasma Insulin-like Growth Factor-1 and Binding Protein-3 and Risk of Colorectal Neoplasia in Women

Edward Giovannucci, Michael N. Pollak, Elizabeth A. Platz, Walter C. Willett, Meir J. Stampfer, Noreen Majeed, Graham A. Colditz, Frank E. Speizer and Susan E. Hankinson
Edward Giovannucci
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael N. Pollak
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elizabeth A. Platz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Walter C. Willett
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Meir J. Stampfer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Noreen Majeed
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Graham A. Colditz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Frank E. Speizer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Susan E. Hankinson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published April 2000
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Tables

  • Table 1

    Characteristics of IGF-1 and IGFBP-3 in the underlying (control) population

    Cancer controlsAdenoma controls
    n 158207
    Median age (yr)6259
    IGF (ng/ml)
    Mean149.6166.7
    Median140.0158.5
    IGFBP-3 (ng/ml)
    Mean37243837
    Median37053809
    Pearson correlation (r)
    IGF-1 and IGFBP-30.530.50
    IGF-1 and age−0.23−0.27
    IGF-1 and agea−0.34−0.29
    IGFBP-3 and age−0.10−0.04
    • a IGF-1 is adjusted for IGFBP-3 level by residual analysis.

  • Table 2

    RR and 95% CI of colorectal cancer, intermediate/late-stage colorectal adenoma, and early-stage colorectal adenoma according to tertiles of IGF-1 and IGFBP-3 in the NHS, 1989–1994

    Tertile 1Tertile 2Tertile 3P, trend
    Colorectal cancer
    IGF-1
    No. of Cases212731
    No. of controls525353
    RRa1.00.801.21
    RRb1.00.912.18
    95% CI0.42–1.990.94–5.080.10
    IGFBP-3
    No. of cases293218
    No. of controls535352
    RRa1.01.150.53
    RRb1.00.970.28
    95% CI0.48–1.960.10–0.830.05
    Intermediate/Late-stage adenomac
    IGF-1
    No. of cases323820
    No. of controls372825
    RRa1.01.140.82
    RRb1.02.102.78
    95% CI0.92–4.830.76–9.760.24
    IGFBP-3
    No. of cases303921
    No. of controls292833
    RRa1.01.130.47
    RRb1.01.040.28
    95% CI0.46–2.320.09–0.850.04
    Early-stage adenomac
    IGF-1
    No. of cases353141
    No. of controls283841
    RRa1.00.640.99
    RRb1.00.540.65
    95% CI0.24–1.240.27–1.580.52
    IGFBP-3
    No. of cases373535
    No. of controls383633
    RRa1.00.981.02
    RRb1.01.281.41
    95% CI0.58–2.830.59–3.360.68
    • a Adjusted for alcohol intake and BMI. Cutpoints for IGF-1 and IGFBP-3 tertiles for cancer and adenoma matched pairs were determined separately. For cancers, mediums and ranges for increasing tertiles of IGF-1 (ng/ml) are 108 (56–132), and 159 (133–182), and 223 (183–401); and for IGFBP-3 (ng/ml), these are 3140 (939–3465), 3809 (3466–4212), and 4543 (4213–5753). For adenomas, for IGF-1 these are 96 (44–116), 139 (117–165), and 199 (166–387); and for IGFBP-3, these are 2834 (1628–3230), 3694, (3231–4063), and 4602 (4064–6790).

    • b Adjusted for alcohol intake and BMI; IGF-1 and IGFBP-3 are mutually adjusted for each other.

    • c Intermediate/late-stage adenomas include those ≥1 cm in diameter or that have a tubulovillous/villous histology, and early-stage adenomas are those <1 cm in diameter and with a tubular histology.

PreviousNext
Back to top
April 2000
Volume 9, Issue 4
  • Table of Contents

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Epidemiology, Biomarkers & Prevention article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
A Prospective Study of Plasma Insulin-like Growth Factor-1 and Binding Protein-3 and Risk of Colorectal Neoplasia in Women
(Your Name) has forwarded a page to you from Cancer Epidemiology, Biomarkers & Prevention
(Your Name) thought you would be interested in this article in Cancer Epidemiology, Biomarkers & Prevention.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
A Prospective Study of Plasma Insulin-like Growth Factor-1 and Binding Protein-3 and Risk of Colorectal Neoplasia in Women
Edward Giovannucci, Michael N. Pollak, Elizabeth A. Platz, Walter C. Willett, Meir J. Stampfer, Noreen Majeed, Graham A. Colditz, Frank E. Speizer and Susan E. Hankinson
Cancer Epidemiol Biomarkers Prev April 1 2000 (9) (4) 345-349;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
A Prospective Study of Plasma Insulin-like Growth Factor-1 and Binding Protein-3 and Risk of Colorectal Neoplasia in Women
Edward Giovannucci, Michael N. Pollak, Elizabeth A. Platz, Walter C. Willett, Meir J. Stampfer, Noreen Majeed, Graham A. Colditz, Frank E. Speizer and Susan E. Hankinson
Cancer Epidemiol Biomarkers Prev April 1 2000 (9) (4) 345-349;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Urinary Melatonin in Relation to Breast Cancer Risk
  • Endometrial Cancer and Ovarian Cancer Cross-Cancer GWAS
  • Risk Factors of Subsequent CNS Tumor after Pediatric Cancer
Show more Research Articles
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • Online First
  • Current Issue
  • Past Issues

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Epidemiology, Biomarkers & Prevention

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Epidemiology, Biomarkers & Prevention
eISSN: 1538-7755
ISSN: 1055-9965

Advertisement