Article Figures & Data
Tables
- Table 1
Characteristics of IGF-1 and IGFBP-3 in the underlying (control) population
Cancer controls Adenoma controls n 158 207 Median age (yr) 62 59 IGF (ng/ml) Mean 149.6 166.7 Median 140.0 158.5 IGFBP-3 (ng/ml) Mean 3724 3837 Median 3705 3809 Pearson correlation (r) IGF-1 and IGFBP-3 0.53 0.50 IGF-1 and age −0.23 −0.27 IGF-1 and agea −0.34 −0.29 IGFBP-3 and age −0.10 −0.04 -
a IGF-1 is adjusted for IGFBP-3 level by residual analysis.
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- Table 2
RR and 95% CI of colorectal cancer, intermediate/late-stage colorectal adenoma, and early-stage colorectal adenoma according to tertiles of IGF-1 and IGFBP-3 in the NHS, 1989–1994
Tertile 1 Tertile 2 Tertile 3 P, trend Colorectal cancer IGF-1 No. of Cases 21 27 31 No. of controls 52 53 53 RRa 1.0 0.80 1.21 RRb 1.0 0.91 2.18 95% CI 0.42–1.99 0.94–5.08 0.10 IGFBP-3 No. of cases 29 32 18 No. of controls 53 53 52 RRa 1.0 1.15 0.53 RRb 1.0 0.97 0.28 95% CI 0.48–1.96 0.10–0.83 0.05 Intermediate/Late-stage adenomac IGF-1 No. of cases 32 38 20 No. of controls 37 28 25 RRa 1.0 1.14 0.82 RRb 1.0 2.10 2.78 95% CI 0.92–4.83 0.76–9.76 0.24 IGFBP-3 No. of cases 30 39 21 No. of controls 29 28 33 RRa 1.0 1.13 0.47 RRb 1.0 1.04 0.28 95% CI 0.46–2.32 0.09–0.85 0.04 Early-stage adenomac IGF-1 No. of cases 35 31 41 No. of controls 28 38 41 RRa 1.0 0.64 0.99 RRb 1.0 0.54 0.65 95% CI 0.24–1.24 0.27–1.58 0.52 IGFBP-3 No. of cases 37 35 35 No. of controls 38 36 33 RRa 1.0 0.98 1.02 RRb 1.0 1.28 1.41 95% CI 0.58–2.83 0.59–3.36 0.68 -
a Adjusted for alcohol intake and BMI. Cutpoints for IGF-1 and IGFBP-3 tertiles for cancer and adenoma matched pairs were determined separately. For cancers, mediums and ranges for increasing tertiles of IGF-1 (ng/ml) are 108 (56–132), and 159 (133–182), and 223 (183–401); and for IGFBP-3 (ng/ml), these are 3140 (939–3465), 3809 (3466–4212), and 4543 (4213–5753). For adenomas, for IGF-1 these are 96 (44–116), 139 (117–165), and 199 (166–387); and for IGFBP-3, these are 2834 (1628–3230), 3694, (3231–4063), and 4602 (4064–6790).
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b Adjusted for alcohol intake and BMI; IGF-1 and IGFBP-3 are mutually adjusted for each other.
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c Intermediate/late-stage adenomas include those ≥1 cm in diameter or that have a tubulovillous/villous histology, and early-stage adenomas are those <1 cm in diameter and with a tubular histology.
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