A Prospective Study of Plasma Insulin-like Growth Factor-1 and Binding Protein-3 and Risk of Colorectal Neoplasia in Women

Edward Giovannucci; Michael N. Pollak; Elizabeth A. Platz; Walter C. Willett; Meir J. Stampfer; Noreen Majeed; Graham A. Colditz; Frank E. Speizer; Susan E. Hankinson

DOI: Published April 2000

Article Figures & Data

Tables

Table 1

Characteristics of IGF-1 and IGFBP-3 in the underlying (control) population

	Cancer controls	Adenoma controls
n	158	207
Median age (yr)	62	59
IGF (ng/ml)
Mean	149.6	166.7
Median	140.0	158.5
IGFBP-3 (ng/ml)
Mean	3724	3837
Median	3705	3809
Pearson correlation (r)
IGF-1 and IGFBP-3	0.53	0.50
IGF-1 and age	−0.23	−0.27
IGF-1 and age^a	−0.34	−0.29
IGFBP-3 and age	−0.10	−0.04

^a IGF-1 is adjusted for IGFBP-3 level by residual analysis.

Table 2

RR and 95% CI of colorectal cancer, intermediate/late-stage colorectal adenoma, and early-stage colorectal adenoma according to tertiles of IGF-1 and IGFBP-3 in the NHS, 1989–1994

	Tertile 1	Tertile 2	Tertile 3	P, trend
Colorectal cancer
IGF-1
No. of Cases	21	27	31
No. of controls	52	53	53
RR^a	1.0	0.80	1.21
RR^b	1.0	0.91	2.18
95% CI		0.42–1.99	0.94–5.08	0.10
IGFBP-3
No. of cases	29	32	18
No. of controls	53	53	52
RR^a	1.0	1.15	0.53
RR^b	1.0	0.97	0.28
95% CI		0.48–1.96	0.10–0.83	0.05
Intermediate/Late-stage adenoma^c
IGF-1
No. of cases	32	38	20
No. of controls	37	28	25
RR^a	1.0	1.14	0.82
RR^b	1.0	2.10	2.78
95% CI		0.92–4.83	0.76–9.76	0.24
IGFBP-3
No. of cases	30	39	21
No. of controls	29	28	33
RR^a	1.0	1.13	0.47
RR^b	1.0	1.04	0.28
95% CI		0.46–2.32	0.09–0.85	0.04
Early-stage adenoma^c
IGF-1
No. of cases	35	31	41
No. of controls	28	38	41
RR^a	1.0	0.64	0.99
RR^b	1.0	0.54	0.65
95% CI		0.24–1.24	0.27–1.58	0.52
IGFBP-3
No. of cases	37	35	35
No. of controls	38	36	33
RR^a	1.0	0.98	1.02
RR^b	1.0	1.28	1.41
95% CI		0.58–2.83	0.59–3.36	0.68

^a Adjusted for alcohol intake and BMI. Cutpoints for IGF-1 and IGFBP-3 tertiles for cancer and adenoma matched pairs were determined separately. For cancers, mediums and ranges for increasing tertiles of IGF-1 (ng/ml) are 108 (56–132), and 159 (133–182), and 223 (183–401); and for IGFBP-3 (ng/ml), these are 3140 (939–3465), 3809 (3466–4212), and 4543 (4213–5753). For adenomas, for IGF-1 these are 96 (44–116), 139 (117–165), and 199 (166–387); and for IGFBP-3, these are 2834 (1628–3230), 3694, (3231–4063), and 4602 (4064–6790).
^b Adjusted for alcohol intake and BMI; IGF-1 and IGFBP-3 are mutually adjusted for each other.
^c Intermediate/late-stage adenomas include those ≥1 cm in diameter or that have a tubulovillous/villous histology, and early-stage adenomas are those <1 cm in diameter and with a tubular histology.