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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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The Fourth DeWitt S. Goodman Lecture

Novel Approaches to the Prevention of Colon Cancer by Nutritional Manipulation and Chemoprevention

Bandaru S. Reddy
Bandaru S. Reddy
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DOI:  Published March 2000
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    Fig. 1.

    Amount and types of dietary fat on azoxymethane-induced colon carcinogenesis in F344 rats (4) .

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    Fig. 2.

    Fecal secondary bile acids in healthy subjects from rural Kuopio and urban Helsinki (Finland) and New York (22) .

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    Fig. 3.

    Fecal secondary bile acids in healthy subjects during the high-fat/low-fiber and low-fat/high-fiber dietary regimens.

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    Fig. 4.

    AOM-induced colon tumor inhibition in F344 rats by NSAIDs and celecoxib, a selective COX-2 inhibitor (51 52 53 , 64) .

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    Fig. 5.

    Impact of high- and low-fat dietary regimen on p-XSC-induced colon tumor inhibition in F344 rats (72) .

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    Fig. 6.

    Chemopreventive efficacy of piroxicam and DFMO administered together on AOM-induced colon carcinogenesis in F344 rats (76) . Piroxicam was administered in the diet individually at 200 and 400μ g/g diet or DFMO individually at 2000 and 4000 μg/g diet. In the combination protocol, piroxicam at 100 μg/g diet plus DFMO at 1000μ g/g diet or piroxicam at 200 μg/g diet plus DFMO at 2000 μg/g diet were evaluated for their chemopreventive efficacy.

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March 2000
Volume 9, Issue 3
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Novel Approaches to the Prevention of Colon Cancer by Nutritional Manipulation and Chemoprevention
Bandaru S. Reddy
Cancer Epidemiol Biomarkers Prev March 1 2000 (9) (3) 239-247;

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Novel Approaches to the Prevention of Colon Cancer by Nutritional Manipulation and Chemoprevention
Bandaru S. Reddy
Cancer Epidemiol Biomarkers Prev March 1 2000 (9) (3) 239-247;
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  • Article
    • Abstract
    • Introduction
    • Nutritional Factors and Colon Cancer
    • Dietary Fat and Colon Cancer
    • Dietary Fiber and Colon Cancer
    • Chemoprevention of Colon Cancer
    • Phytochemicals as Chemopreventive Agents
    • NSAIDs as Chemopreventive Agents
    • Organoselenium as a Chemopreventive Agent
    • Combinations of Low Doses of Various Chemopreventive Agents
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
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