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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Etiology of Hepatocellular Carcinoma in Italian Patients with and without Cirrhosis

Roberta Chiesa, Francesco Donato, Alessandro Tagger, Maurizio Favret, Maria Lisa Ribero, Giuseppe Nardi, Umberto Gelatti, Elena Bucella, Enrica Tomasi, Nazario Portolani, Mariafausta Bonetti, Lanberto Bettini, Giovanni Pelizzari, Andrea Salmi, Antonella Savio, Marco Garatti and Francesco Callea
Roberta Chiesa
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Francesco Donato
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Alessandro Tagger
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Maurizio Favret
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Maria Lisa Ribero
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Giuseppe Nardi
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Umberto Gelatti
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Elena Bucella
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Enrica Tomasi
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Nazario Portolani
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Mariafausta Bonetti
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Lanberto Bettini
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Giovanni Pelizzari
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Andrea Salmi
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Antonella Savio
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Marco Garatti
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Francesco Callea
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DOI:  Published February 2000
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    Fig. 1.

    Algorithm followed for classification of total HCC cases in subjects with and without cirrhosis.

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    Prevalence of HBV infection (HbsAg and/or HBV DNA positivity), HCV infection (HCV RNA positivity), heavy alcohol intake, and hemochromatosis in HCC cases with and without cirrhosis.

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  • Table 1

    Distribution of HCC cases without cirrhosis according to the type of underlying liver disease and its presumed etiology

    Definition of the grading and staging of chronic hepatitis is based on the components of the Histologic Activity Index according to Desmet et al. (17). Nonspecific reactive chronic hepatitis was defined according to Liaw et al. (18).

    Liver diseaseTotalRisk factor
    HBsAg and/or HBV DNA positivityHCV RNA positivityAlcohol intake > 80 g/dayHigh liver iron stores
    Chronic viral hepatitis115a7a51
    Grading
    Minimal chronic hepatitis111
    Mild or moderate chronic hepatitis105641
    Staging
    Mild fibrosis5323
    Severe fibrosis (bridging fibrosis)6252
    Alcoholic hepatitis552
    Nonspecific reactive hepatitis32b1
    Hemochromatosis11
    Normal tissue1
    • a One patient was HBsAg positive, HBV DNA negative, and HCV RNA positive; one patient was positive for both HBsAg and HBV DNA, two patients were HBsAg positive and HBV DNA negative; and one patient was HBsAg negative and HBV DNA positive.

    • b One patient was HBsAg positive and HBV DNA negative, and one patient was HBsAg negative and HBV DNA positive.

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February 2000
Volume 9, Issue 2
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Etiology of Hepatocellular Carcinoma in Italian Patients with and without Cirrhosis
Roberta Chiesa, Francesco Donato, Alessandro Tagger, Maurizio Favret, Maria Lisa Ribero, Giuseppe Nardi, Umberto Gelatti, Elena Bucella, Enrica Tomasi, Nazario Portolani, Mariafausta Bonetti, Lanberto Bettini, Giovanni Pelizzari, Andrea Salmi, Antonella Savio, Marco Garatti and Francesco Callea
Cancer Epidemiol Biomarkers Prev February 1 2000 (9) (2) 213-216;

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Etiology of Hepatocellular Carcinoma in Italian Patients with and without Cirrhosis
Roberta Chiesa, Francesco Donato, Alessandro Tagger, Maurizio Favret, Maria Lisa Ribero, Giuseppe Nardi, Umberto Gelatti, Elena Bucella, Enrica Tomasi, Nazario Portolani, Mariafausta Bonetti, Lanberto Bettini, Giovanni Pelizzari, Andrea Salmi, Antonella Savio, Marco Garatti and Francesco Callea
Cancer Epidemiol Biomarkers Prev February 1 2000 (9) (2) 213-216;
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