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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Research Articles

Genetic Polymorphism of Cytochrome P450–1B1 and Risk of Breast Cancer

Wei Zheng, Da-Wen Xie, Fan Jin, Jia-Rong Cheng, Qi Dai, Wan-Qing Wen, Xiao-Ou Shu and Yu-Tang Gao
Wei Zheng
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Da-Wen Xie
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Fan Jin
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Jia-Rong Cheng
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Qi Dai
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Wan-Qing Wen
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Xiao-Ou Shu
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Yu-Tang Gao
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DOI:  Published February 2000
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    Fig. 1.

    Gel electrophoresis after RFLP analysis of the 650-bp CYP1B1 PCR product. Representative genotypes are shown in Lane 1 (homozygous for the Leu allele), Lane 2 (heterozygous for the Leu allele), and Lane 3 (homozygous for the Val allele).

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  • Table 1

    Comparison of cases and controls by selected demographics and breast cancer risk factors, Shanghai Breast Cancer Study, 1996–1998

    Cases (n = 186)aControls (n = 200)aOR (95% CI)
    Demographic factors
    Age (yr)47 (42, 53)b46 (41, 55)b
    Education ≥ high school40.343.00.9 (0.6–1.3)
    Major risk factors
    First-degree relative with breast cancer1.62.00.8 (0.2–3.6)
    Ever diagnosed with breast fibroadenoma9.74.02.6 (1.1–6.1)
    No regular leisure physical activity80.169.01.8 (1.1–2.9)
    Waist:hip ratio ≥0.8521.618.51.2 (0.7–2.0)
    Body mass index ≥2527.022.51.3 (0.8–2.0)
    Age at menarche ≤12 yr9.27.51.2 (0.6–2.6)
    Age at menopause ≥50 yrc50.038.01.6 (0.8–3.2)
    Age at first live birth ≥30 yrd25.616.01.8 (1.1–3.0)
    • a Unless otherwise specified, percentages are presented.

    • b Median (25th, 75th percentile) are presented.

    • c Among postmenopausal women.

    • d Among parous women.

  • Table 2

    Associations of CYP1B1 genotype with breast cancer risk, Shanghai Breast Cancer Study, 1996–1998

    CYP1B1 genotypeNo. of cases (n = 186)No. of controls (n = 200)Unadjusted OR (95% CI)Adjusteda OR (95% CI)
    All study participants
    Val/Val 37441.01.0
    Val/Leu 1011270.9 (0.6–1.6)1.0 (0.6–1.7)
    Leu/Leu 48292.0 (1.0–3.7)2.3 (1.2–4.3)
    Premenopausal women
    Val/Val 26261.01.0
    Val/Leu 68780.9 (0.5–1.6)1.0 (0.5–1.9)
    Leu/Leu 27171.6 (0.7–3.6)1.9 (0.8–4.3)
    Postmenopausal women
    Val/Val 11181.01.0
    Val/Leu 32491.1 (0.4–2.6)1.1 (0.4–2.6)
    Leu/Leu 21122.9 (1.0–8.0)3.1 (1.0–9.1)
    • a Adjusted for prior history of breast fibroadenoma, physical activity, and age at first pregnancy.

  • Table 3

    Adjusted ORs for potential joint effect of CYP1B1 genotype with selected risk factors, Shanghai Breast Cancer Study, 1996–1998

    Risk factorsCYP1B1 Val/Val + Val/LeuCYP1B1 Leu/Leu
    Case/controlOR (95% CI)aCase/controlOR (95% CI)a
    Ever diagnosed with breast fibroadenoma
    No123/1651.045/272.4 (1.4–4.1)
    Yes15/63.2 (1.2–8.6)3/22.1 (0.3–13.2)
    Physical activity
    High24/531.013/93.5 (1.3–9.5)
    Low114/1182.1 (1.2–3.6)35/203.8 (1.8–7.9)
    Age at first live birth (by median)b
    ≤26 years59/931.025/162.6 (1.3–5.3)
    >26 years74/721.5 (1.0–2.5)21/112.8 (1.3–6.3)
    • a With the exception of the variables under evaluation, ORs were adjusted for the other two variables listed in the table.

    • b Among parous women.

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February 2000
Volume 9, Issue 2
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Genetic Polymorphism of Cytochrome P450–1B1 and Risk of Breast Cancer
Wei Zheng, Da-Wen Xie, Fan Jin, Jia-Rong Cheng, Qi Dai, Wan-Qing Wen, Xiao-Ou Shu and Yu-Tang Gao
Cancer Epidemiol Biomarkers Prev February 1 2000 (9) (2) 147-150;

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Genetic Polymorphism of Cytochrome P450–1B1 and Risk of Breast Cancer
Wei Zheng, Da-Wen Xie, Fan Jin, Jia-Rong Cheng, Qi Dai, Wan-Qing Wen, Xiao-Ou Shu and Yu-Tang Gao
Cancer Epidemiol Biomarkers Prev February 1 2000 (9) (2) 147-150;
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