A Prospective Study of the Effect of Alcohol Consumption and ADH3 Genotype on Plasma Steroid Hormone Levels and Breast Cancer Risk

DOI: Published October 2000

Article Figures & Data

Table 1

ADH3 genotype and breast cancer risk

ADH3 genotype	Cases, n (%)	Controls, n (%)	RR (95% CI) Matched^a,b	RR (95% CI) Multivariate^c,d
All women
Fast	153 (33)	211 (34)	1.0 (Ref)^e	1.0 (Ref)
Intermediate	239 (51)	300 (48)	1.2 (0.9–1.5)	1.1 (0.8–1.4)
Slow	73 (16)	110 (18)	1.0 (0.7–1.5)	0.9 (0.6–1.3)
Premenopausal
Fast	30 (33)	35 (36)	1.0 (Ref)	1.0 (Ref)
Intermediate	47 (52)	48 (50)	1.2 (0.6–2.2)	1.1 (0.5–2.5)
Slow	14 (15)	14 (14)	1.1 (0.5–2.8)	1.4 (0.5–4.0)
Postmenopausal
Fast	106 (32)	157 (33)	1.0 (Ref)	1.0 (Ref)
Intermediate	168 (51)	236 (49)	1.1 (0.8–1.5)	0.9 (0.6–1.3)
Slow	54 (17)	88 (18)	1.0 (0.6–1.5)	0.7 (0.5–1.2)

^a Matched on year of birth, menopausal status, postmenopausal hormone use, fasting status, time and date of blood draw.
^b Unconditional logistic regression controlling for the matching factors was utilized for premenopausal women because of small sample size.
^c In addition to matching factors, controlled for parity, age of first birth, age of menarche, body mass index, family history, alcohol consumption, benign breast disease, weight gain since age 18, age of menopause, and duration of postmenopausal hormone use.
^d Unconditional logistic regression controlling for the matching factors, parity, age of first birth, age of menarche, body mass index, family history, alcohol consumption, benign breast disease, and weight gain since age 18 was utilized for premenopausal women because of small sample size.
^e Ref, within reference values.

Table 2

RRs and 95% CIs for breast cancer risk stratified by ADH3 genotype and daily alcohol consumption prior to diagnosis

^a Unconditional logistic regression controlling for the matching factors was utilized for determining trend within each genotype because of small sample size.
^b Numbers of cases and controls do not total 465 and 621 because of missing data on alcohol intake.
^c Matched on year of birth, menopausal status, postmenopausal hormone use, fasting status, time and date of blood draw.
^d In addition to matching factors, controlled for parity, age of first birth, age of menarche, body mass index, family history, alcohol consumption, benign breast disease, weight gain since age 18, age of menopause, and duration of postmenopausal hormone use.
^e Likelihood ratio test for the interaction between genotype and alcohol consumption adjusted for the matching factors.
^f Likelihood ratio test for the interaction between genotype and alcohol consumption adjusted for the matching factors and previously described risk factors.

Table 3

RRs and 95% CIs for breast cancer risk stratified by ADH3 genotype and daily alcohol consumption prior to diagnosis among postmenopausal women

^a Unconditional logistic regression controlling for the matching factors was utilized for determining trend within each genotype because of small sample size.
^b Numbers of cases and controls do not total 328 and 481 because of missing data on alcohol intake.
^c Matched on year of birth, menopausal status, postmenopausal hormone use, fasting status, time and date of blood draw.
^d Ref, within reference values.
^e In addition to matching factors, controlled for parity, age of first birth, age of menarche, body mass index, family history, alcohol consumption, benign breast disease, weight gain since age 18, age of menopause, and duration of postmenopausal hormone use.
^f Likelihood ratio test for the interaction between genotype and alcohol consumption adjusted for the matching factors.
^g Likelihood ratio test for the interaction between genotype and alcohol consumption adjusted for the matching factors and previously described risk factors.

Table 4

Pearson correlations between current alcohol intake and plasma hormone levels^a