Article Figures & Data
Tables
- Table 1
ADH3 genotype and breast cancer risk
ADH3 genotype Cases, n (%) Controls, n (%) RR (95% CI) Matcheda,b RR (95% CI) Multivariatec,d All women Fast 153 (33) 211 (34) 1.0 (Ref)e 1.0 (Ref) Intermediate 239 (51) 300 (48) 1.2 (0.9–1.5) 1.1 (0.8–1.4) Slow 73 (16) 110 (18) 1.0 (0.7–1.5) 0.9 (0.6–1.3) Premenopausal Fast 30 (33) 35 (36) 1.0 (Ref) 1.0 (Ref) Intermediate 47 (52) 48 (50) 1.2 (0.6–2.2) 1.1 (0.5–2.5) Slow 14 (15) 14 (14) 1.1 (0.5–2.8) 1.4 (0.5–4.0) Postmenopausal Fast 106 (32) 157 (33) 1.0 (Ref) 1.0 (Ref) Intermediate 168 (51) 236 (49) 1.1 (0.8–1.5) 0.9 (0.6–1.3) Slow 54 (17) 88 (18) 1.0 (0.6–1.5) 0.7 (0.5–1.2) -
a Matched on year of birth, menopausal status, postmenopausal hormone use, fasting status, time and date of blood draw.
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b Unconditional logistic regression controlling for the matching factors was utilized for premenopausal women because of small sample size.
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c In addition to matching factors, controlled for parity, age of first birth, age of menarche, body mass index, family history, alcohol consumption, benign breast disease, weight gain since age 18, age of menopause, and duration of postmenopausal hormone use.
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d Unconditional logistic regression controlling for the matching factors, parity, age of first birth, age of menarche, body mass index, family history, alcohol consumption, benign breast disease, and weight gain since age 18 was utilized for premenopausal women because of small sample size.
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e Ref, within reference values.
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- Table 2
RRs and 95% CIs for breast cancer risk stratified by ADH3 genotype and daily alcohol consumption prior to diagnosis
ADH3 genotype Alcohol consumption P, test for trenda None ≤10 g/day ≥10 g/day Combined Cases, n (%)b 138 (30) 213 (47) 104 (23) Controls, n (%)b 195 (32) 268 (44) 149 (24) Matched RRc 1.0 (Ref) 1.1 (0.8–1.5) 0.9 (0.6–1.3) 0.35 Multivariate RRd 1.0 (Ref) 1.2 (0.9–1.6) 1.1 (0.7–1.6) 0.94 Fast Cases, n (%) 55 (12) 63 (14) 31 (7) Controls, n (%) 61 (10) 98 (16) 47 (8) Matched RRc 1.0 (Ref) 0.8 (0.5–1.3) 0.7 (0.4–1.3) 0.49 Multivariate RRd 1.0 (Ref) 0.8 (0.5–1.3) 0.8 (0.4–1.5) 0.83 Intermediate Cases, n (%) 61 (13) 124 (27) 50 (11) Controls, n (%) 97 (16) 127 (21) 72 (12) Matched RRc 0.8 (0.5–1.3) 1.2 (0.7–1.8) 0.8 (0.5–1.3) 0.60 Multivariate RRd 0.7 (0.4–1.2) 1.1 (0.7–1.8) 0.8 (0.4–1.4) 0.91 Slow Cases, n (%) 22 (5) 26 (6) 23 (5) Controls, n (%) 37 (6) 43 (7) 30 (5) Matched RRc 0.7 (0.4–1.4) 0.7 (0.4–1.4) 1.0 (0.5–1.9) 0.58 Multivariate RRd 0.6 (0.3–1.2) 0.6 (0.3–1.2) 1.1 (0.5–2.4) 0.21 LRT,e P = 0.35 LRT,f P = 0.15 -
a Unconditional logistic regression controlling for the matching factors was utilized for determining trend within each genotype because of small sample size.
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b Numbers of cases and controls do not total 465 and 621 because of missing data on alcohol intake.
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c Matched on year of birth, menopausal status, postmenopausal hormone use, fasting status, time and date of blood draw.
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d In addition to matching factors, controlled for parity, age of first birth, age of menarche, body mass index, family history, alcohol consumption, benign breast disease, weight gain since age 18, age of menopause, and duration of postmenopausal hormone use.
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e Likelihood ratio test for the interaction between genotype and alcohol consumption adjusted for the matching factors.
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f Likelihood ratio test for the interaction between genotype and alcohol consumption adjusted for the matching factors and previously described risk factors.
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- Table 3
RRs and 95% CIs for breast cancer risk stratified by ADH3 genotype and daily alcohol consumption prior to diagnosis among postmenopausal women
ADH3 genotype Alcohol consumption P, test for trenda None ≤10 g/day >10 g/day Combined Cases, n (%)b 89 (28) 146 (46) 86 (27) Controls, n (%)b 150 (32) 210 (44) 114 (24) Matched RRc 1.0 (Ref)d 1.2 (0.8–1.7) 1.2 (0.8–1.8) 0.62 Multivariate RRe 1.0 (Ref) 1.3 (0.9–1.9) 1.3 (0.9–2.1) 0.41 Fast Cases, n (%) 34 (11) 45 (14) 25 (8) Controls, n (%) 48 (10) 73 (15) 33 (7) Matched RRc 1.0 (Ref) 1.0 (0.5–1.7) 1.1 (0.5–2.2) 0.81 Multivariate RRe 1.0 (Ref) 1.0 (0.5–1.9) 1.2 (0.5–2.8) 0.60 Intermediate Cases, n (%) 40 (13) 84 (26) 41 (13) Controls, n (%) 73 (15) 102 (22) 57 (12) Matched RRc 0.9 (0.5–1.7) 1.3 (0.7–2.2) 1.1 (0.6–2.0) 0.98 Multivariate RRe 0.7 (0.4–1.5) 1.2 (0.6–2.2) 0.9 (0.5–1.9) 0.71 Slow Cases, n (%) 15 (5) 17 (5) 20 (6) Controls, n (%) 29 (6) 35 (7) 24 (5) Matched RRc 0.8 (0.4–1.9) 0.7 (0.3–1.5) 1.3 (0.6–2.7) 0.50 Multivariate RRe 0.6 (0.2–1.5) 0.6 (0.3–1.4) 1.3 (0.5–3.0) 0.17 LRT,f P = 0.56 LRT,g P = 0.45 -
a Unconditional logistic regression controlling for the matching factors was utilized for determining trend within each genotype because of small sample size.
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b Numbers of cases and controls do not total 328 and 481 because of missing data on alcohol intake.
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c Matched on year of birth, menopausal status, postmenopausal hormone use, fasting status, time and date of blood draw.
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d Ref, within reference values.
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e In addition to matching factors, controlled for parity, age of first birth, age of menarche, body mass index, family history, alcohol consumption, benign breast disease, weight gain since age 18, age of menopause, and duration of postmenopausal hormone use.
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f Likelihood ratio test for the interaction between genotype and alcohol consumption adjusted for the matching factors.
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g Likelihood ratio test for the interaction between genotype and alcohol consumption adjusted for the matching factors and previously described risk factors.
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- Table 4
Pearson correlations between current alcohol intake and plasma hormone levelsa
Hormone r (P) P, test for trend Combined Fast Intermediate Slow Estrone sulfate 0.14 (0.02) 0.26 (0.02) 0.08 (0.34) 0.19 (0.15) 0.84 n = 278 n = 83 n = 138 n = 57 Estrone 0.03 (0.57) 0.15 (0.18) −0.03 (0.74) 0.09 (0.49) 0.88 n = 297 n = 84 n = 152 n = 61 Estradiol 0.07 (0.23) 0.23 (0.03) −0.01 (0.93) −0.01 (0.96) 0.21 n = 296 n = 83 n = 151 n = 62 Free estradiol 0.09 (0.11) 0.23 (0.04) 0.02 (0.80) 0.07 (0.60) 0.35 n = 291 n = 83 n = 148 n = 60 % free estradiol 0.06 (0.33) 0.02 (0.85) 0.08 (0.35) 0.14 (0.29) 0.59 n = 295 n = 84 n = 151 n = 60 Bioavailable estradiol 0.14 (0.02) 0.21 (0.06) 0.08 (0.35) 0.22 (0.09) 0.97 n = 293 n = 83 n = 151 n = 59 % bioavailable estradiol 0.14 (0.01) 0.17 (0.12) 0.13 (0.12) 0.12 (0.35) 0.79 n = 298 n = 84 n = 153 n = 61 Androstenedione −0.02 (0.75) 0.11 (0.34) −0.10 (0.25) −0.04 (0.77) 0.39 n = 289 n = 82 n = 146 n = 61 Testosterone −0.11 (0.06) 0.08 (0.50) −0.19 (0.02) −0.19 (0.13) 0.07 n = 291 n = 82 n = 148 n = 61 DHEA 0.00 (0.98) 0.17 (0.14) −0.08 (0.37) −0.02 (0.90) 0.23 n = 266 n = 76 n = 136 n = 54 DHEAS 0.06 (0.30) 0.28 (0.01) 0.08 (0.32) −0.23 (0.08) 0.01 n = 292 n = 80 n = 151 n = 61 SHBG −0.13 (0.03) 0.04 (0.75) −0.17 (0.03) −0.22 (0.10) 0.02 n = 289 n = 83 n = 149 n = 57 -
a Adjusted for smoking, body mass index, age, and laboratory batch.
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