Article Figures & Data
Figures
- Fig. 1.
Role of methionine synthase (MS) and MTHFR in folate/homocyst(e)ine/methionine metabolism.
Tables
- Table 1
Frequency of MTR genotypes and age-adjusted risk of colorectal cancer by MTR genotype among participants of the Physicians’ Health Study (PHS) and the Health Professional Follow-up Study (HPFS)
MTR genotype Cases Controls OR 95% CI N (%) N (%) PHS asp/asp 145 (68) 235 (68) 1.00 ref.a asp/gly 61 (29) 95 (27) 1.04 0.71–1.53 gly/gly 6 (3) 16 (5) 0.63 0.24–1.64 Total 212 346 HPFS asp/asp 103 (72) 82 (63) 1.00 ref. asp/gly 37 (26) 42 (32) 0.71 0.42–1.20 gly/gly 4 (3) 6 (5) 0.53 0.14–1.93 Total 144 130 PHS and HPFS asp/asp 248 (70) 317 (66) 1.00 ref. asp/gly 98 (28) 137 (29) 0.92 0.67–1.25 gly/gly 10 (3) 22 (5) 0.59 0.27–1.27 Total 356 476 -
a ref., reference.
-
- Table 2
Age-adjusted mean of folate (geometric mean), B12, and homocyst(e)ine by case/control status and genotypes of MTR and MTHFR among the PHS participants
Case Controls N Mean N Mean MTR genotype Folate asp/asp 126 4.13 218 4.29 gly/asp 53 4.17 87 3.80 gly/gly 6 4.60 14 3.88 B12 asp/asp 126 452 218 477 gly/asp 53 494 87 476 gly/gly 6 542 14 506 Homocyst(e)ine asp/asp 115 12.9 200 12.3 gly/asp 49 11.6 79 11.9 gly/gly 6 12.8 11 11.4 MTHFR genotype Folate ala/ala 81 4.54 138 4.39 val/ala 81 3.87 116 4.07 val/val 14 3.12a 46 3.50a B12 ala/ala 81 471 138 503 val/ala 81 462 116 468 val/val 14 431 46 440 Homocyst(e)ine ala/ala 79 12.0 135 12.2 val/ala 78 12.3 111 11.8 val/val 13 17.6b 43 13.1 -
a P ≤ 0.05.
-
b P ≤ 0.01 for val/valgenotype versus ala/ala genotype.
-
- Table 3
Age-adjusted risk of colorectal cancer according to MTR and MTHFR genotypes and levels of folate and homocyst(e)ine among the PHS participants
Folate (ng/ml) Homocyst(e)ine (mg/dl) Tertile 1 Tertile 2 and 3 Tertile 1 and 2 Tertile 3 MTR asp/asp or gly/asp Number 51/102 128/203 100/186 64/93 OR (95% CI) 0.84 (0.56–1.27) 1.00 (ref) 1.00 (ref) 1.21 (0.81–1.82) MTR gly/gly Number 3/4 3/10 4/7 2/4 OR (95% CI) 1.25 (0.27–5.69) 0.51 (0.14–1.90) 1.10 (0.31–3.90) 1.05 (0.19–5.85) Pinteraction = 0.22 Pinteraction = 0.37 MTHFR ala/ala or val/ala Number 45/83 117/171 100/167 57/79 OR (95% CI) 0.88 (0.56–1.36) 1.00 (ref) 1.00 (ref) 1.16 (0.76–1.78) MTHFR val/val Number 8/18 6/28 4/25 9/18 OR (95% CI) 0.57 (0.24–1.38) 0.29 (0.12–0.73) 0.25 (0.08–0.74) 0.69 (0.29–1.62) Pinteraction = 0.16 Pinteraction = 0.24 - Table 4
Age-adjusted risk of colorectal cancer according to MTR genotype and alcohol intake among United States physicians and health professionals in the PHS and HPFS
MTR genotype Alcohol intake <1 drink/day ≥1 drink/day asp/asp Number 162/210 86/104 OR (95% CI) 1.00 (ref.) 1.04 (0.73–1.49) gly/asp Number 57/86 41/50 OR (95% CI) 0.88 (0.59–1.30) 1.03 (0.64–1.63) gly/gly Number 4/19 6/3 OR (95% CI) 0.27 (0.09–0.81) 2.64 (0.65–10.82) Ptrend = 0.04 Ptrend = 0.52 Pinteraction = 0.04
Volume 8, Issue 9
