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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Design and recruitment for retinoid skin cancer prevention (SKICAP) trials. The Southwest Skin Cancer Prevention Study Group.

T E Moon, N Levine, B Cartmel, J Bangert, S Rodney, M Schreiber, Y M Peng, C Ritenbaugh, F Meyskens and D Alberts
T E Moon
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N Levine
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B Cartmel
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J Bangert
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S Rodney
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M Schreiber
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Y M Peng
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C Ritenbaugh
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F Meyskens
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D Alberts
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DOI:  Published September 1995
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Abstract

The retinoid skin cancer prevention (SKICAP) trials are a set of double-blind, randomized, placebo-controlled clinical trials. The SKICAP-actinic keratoses (AK) trial tests the hypothesis that daily supplementation of retinol (25,000 IU) for 5 years reduces the incidence of skin cancers in high-risk individuals, those with a history of greater than ten clinically or pathologically diagnosed AK and, at most, one prior pathologically confirmed cutaneous squamous cell carcinoma (SCC) or basal cell carcinoma (BCC). The SKICAP-SCC/BCC (S/B) trial tests the hypothesis that daily supplementation of retinol (25,000 IU) or 13-cis-retinoic acid (5 or 10 mg) for 3 years reduces skin cancer incidence in very high-risk individuals, those with a history of at least four pathologically confirmed SCCs or BCCs. Between 1984 and 1988, 2800 participants were enrolled at two clinics on the SKICAP-AK trial; and between 1985 and 1990, a total of 719 participants were enrolled at four clinics on the SKICAP-S/B trial. The initial recruitment strategy was referral by dermatologists, but low accrual necessitated the use of other strategies to achieve enrollment goals, which included involving additional clinics and using paid trial-specific advertisements in print and electronic media. Thirteen % of the SKICAP-AK participants and 36% of the SKICAP-S/B participants were enrolled through dermatologist referral, whereas paid advertisements resulted in enrollment of 87% of SKICAP-AK and 43% of SKICAP-S/B participants. A population-based skin cancer registry was used to identify and enroll the remaining 21% of the SKICAP-S/B participants.(ABSTRACT TRUNCATED AT 250 WORDS)

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September 1995
Volume 4, Issue 6
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Design and recruitment for retinoid skin cancer prevention (SKICAP) trials. The Southwest Skin Cancer Prevention Study Group.
T E Moon, N Levine, B Cartmel, J Bangert, S Rodney, M Schreiber, Y M Peng, C Ritenbaugh, F Meyskens and D Alberts
Cancer Epidemiol Biomarkers Prev September 1 1995 (4) (6) 661-669;

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Design and recruitment for retinoid skin cancer prevention (SKICAP) trials. The Southwest Skin Cancer Prevention Study Group.
T E Moon, N Levine, B Cartmel, J Bangert, S Rodney, M Schreiber, Y M Peng, C Ritenbaugh, F Meyskens and D Alberts
Cancer Epidemiol Biomarkers Prev September 1 1995 (4) (6) 661-669;
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