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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Role of Tumor Mutation Burden Analysis in Detecting Lynch Syndrome in Precision Medicine: Analysis of 2,501 Japanese Cancer Patients

Yoshimi Kiyozumi, Hiroyuki Matsubayashi, Satomi Higashigawa, Yasue Horiuchi, Nobuhiro Kado, Yasuyuki Hirashima, Akio Shiomi, Takuma Oishi, Sumiko Ohnami, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima and Ken Yamaguchi
Yoshimi Kiyozumi
1Division of Genetic Medicine Promotion, Shizuoka Cancer Center, Shizuoka, Japan.
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Hiroyuki Matsubayashi
1Division of Genetic Medicine Promotion, Shizuoka Cancer Center, Shizuoka, Japan.
2Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
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  • For correspondence: h.matsubayashi@scchr.jp
Satomi Higashigawa
1Division of Genetic Medicine Promotion, Shizuoka Cancer Center, Shizuoka, Japan.
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Yasue Horiuchi
1Division of Genetic Medicine Promotion, Shizuoka Cancer Center, Shizuoka, Japan.
3Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
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  • ORCID record for Yasue Horiuchi
Nobuhiro Kado
1Division of Genetic Medicine Promotion, Shizuoka Cancer Center, Shizuoka, Japan.
4Division of Gynecology, Shizuoka Cancer Center, Shizuoka, Japan.
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Yasuyuki Hirashima
4Division of Gynecology, Shizuoka Cancer Center, Shizuoka, Japan.
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  • ORCID record for Yasuyuki Hirashima
Akio Shiomi
5Division of Colon and Rectal Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
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  • ORCID record for Akio Shiomi
Takuma Oishi
6Division of Pathology, Shizuoka Cancer Center, Shizuoka, Japan.
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Sumiko Ohnami
7Shizuoka Cancer Center Research Institute, Shizuoka, Japan.
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Keiichi Ohshima
7Shizuoka Cancer Center Research Institute, Shizuoka, Japan.
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Kenichi Urakami
7Shizuoka Cancer Center Research Institute, Shizuoka, Japan.
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Takeshi Nagashima
7Shizuoka Cancer Center Research Institute, Shizuoka, Japan.
8SRL Inc., Tokyo, Japan.
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Ken Yamaguchi
7Shizuoka Cancer Center Research Institute, Shizuoka, Japan.
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DOI: 10.1158/1055-9965.EPI-20-0694 Published January 2021
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Article Information

Volume 30, Issue 1, pp. 166-174

DOI 
https://doi.org/10.1158/1055-9965.EPI-20-0694
PubMed 
33046448

Published By 
American Association for Cancer Research
Print ISSN 
1055-9965
Online ISSN 
1538-7755
History 
  • Received May 7, 2020
  • Revision received July 23, 2020
  • Accepted September 30, 2020
  • Published first October 12, 2020.

Article Versions

  • Previous version (October 12, 2020 - 05:45).
  • Previous version (November 13, 2020 - 05:42).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Yoshimi Kiyozumi1,#,
  2. Hiroyuki Matsubayashi1,2,#,*,
  3. Satomi Higashigawa1,
  4. Yasue Horiuchi1,3,
  5. Nobuhiro Kado1,4,
  6. Yasuyuki Hirashima4,
  7. Akio Shiomi5,
  8. Takuma Oishi6,
  9. Sumiko Ohnami7,
  10. Keiichi Ohshima7,
  11. Kenichi Urakami7,
  12. Takeshi Nagashima7,8, and
  13. Ken Yamaguchi7
  1. 1Division of Genetic Medicine Promotion, Shizuoka Cancer Center, Shizuoka, Japan.
  2. 2Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
  3. 3Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  4. 4Division of Gynecology, Shizuoka Cancer Center, Shizuoka, Japan.
  5. 5Division of Colon and Rectal Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
  6. 6Division of Pathology, Shizuoka Cancer Center, Shizuoka, Japan.
  7. 7Shizuoka Cancer Center Research Institute, Shizuoka, Japan.
  8. 8SRL Inc., Tokyo, Japan.
  1. ↵*Corresponding Author:
    Hiroyuki Matsubayashi, Division of Genetic Medicine Promotion, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan. Phone: 81-55-989-5222; Fax: 81-55-989-5551; E-mail: h.matsubayashi{at}scchr.jp
  1. ↵#Y. Kiyozumi and H. Matsubayashi contributed equally as first authors of this article.

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Cancer Epidemiology Biomarkers & Prevention: 30 (1)
January 2021
Volume 30, Issue 1
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Role of Tumor Mutation Burden Analysis in Detecting Lynch Syndrome in Precision Medicine: Analysis of 2,501 Japanese Cancer Patients
Yoshimi Kiyozumi, Hiroyuki Matsubayashi, Satomi Higashigawa, Yasue Horiuchi, Nobuhiro Kado, Yasuyuki Hirashima, Akio Shiomi, Takuma Oishi, Sumiko Ohnami, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima and Ken Yamaguchi
Cancer Epidemiol Biomarkers Prev January 1 2021 (30) (1) 166-174; DOI: 10.1158/1055-9965.EPI-20-0694

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Role of Tumor Mutation Burden Analysis in Detecting Lynch Syndrome in Precision Medicine: Analysis of 2,501 Japanese Cancer Patients
Yoshimi Kiyozumi, Hiroyuki Matsubayashi, Satomi Higashigawa, Yasue Horiuchi, Nobuhiro Kado, Yasuyuki Hirashima, Akio Shiomi, Takuma Oishi, Sumiko Ohnami, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima and Ken Yamaguchi
Cancer Epidemiol Biomarkers Prev January 1 2021 (30) (1) 166-174; DOI: 10.1158/1055-9965.EPI-20-0694
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