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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Serum Iodine and Breast Cancer Risk: A Prospective Nested Case–Control Study Stratified for Selenium Levels

Jonas Manjer, Malte Sandsveden and Signe Borgquist
Jonas Manjer
1Department of Surgery, Skåne University Hospital Malmö, Lund University, Malmö, Sweden.
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  • For correspondence: jonas.manjer@med.lu.se
Malte Sandsveden
1Department of Surgery, Skåne University Hospital Malmö, Lund University, Malmö, Sweden.
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  • ORCID record for Malte Sandsveden
Signe Borgquist
2Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
3Department of Oncology, Aarhus University Hospital/Aarhus University, Aarhus, Denmark.
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DOI: 10.1158/1055-9965.EPI-20-0122 Published July 2020
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Abstract

Background: Iodine has been suggested to protect against breast cancer, but there are no epidemiologic studies on individual risk. An interesting finding is that in areas where the exposure to both selenium and iodine are high (e.g., Japan), the risk of breast cancer is lower than in areas where selenium is high and iodine low (e.g., United States), or in areas where both are low (e.g., Northern Europe). The aim of this study was to investigate the association between prediagnostic serum iodine levels and subsequent breast cancer risk, and to investigate if this potential association was modified by selenium levels.

Methods: The Malmö Diet and Cancer Study provided prediagnostic serum samples and the current analysis included 1,159 breast cancer cases and 1,136 controls. Levels of baseline serum iodine and selenium were analyzed. A logistic regression analysis yielded ORs with 95% confidence intervals adjusted for potential confounders.

Results: There was no evidence of an overall association between iodine levels and risk of breast cancer. Among women with high selenium levels (above the median), high iodine levels were associated with a lower risk of breast cancer; the OR for above versus below the median was 0.75 (0.57–0.99). The corresponding OR for women with low selenium was 1.15 (0.87–1.50), and the Pinteraction was 0.06.

Conclusions: The combination of high serum iodine levels and high selenium levels was associated with a lower risk of breast cancer.

Impact: A high iodine and selenium exposure may decrease the risk of breast cancer.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Epidemiology, Biomarkers & Prevention Online (http://cebp.aacrjournals.org/).

  • Cancer Epidemiol Biomarkers Prev 2020;29:1335–40

  • Received January 23, 2020.
  • Revision received March 4, 2020.
  • Accepted April 29, 2020.
  • Published first May 26, 2020.
  • ©2020 American Association for Cancer Research.
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Cancer Epidemiology Biomarkers & Prevention: 29 (7)
July 2020
Volume 29, Issue 7
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Serum Iodine and Breast Cancer Risk: A Prospective Nested Case–Control Study Stratified for Selenium Levels
Jonas Manjer, Malte Sandsveden and Signe Borgquist
Cancer Epidemiol Biomarkers Prev July 1 2020 (29) (7) 1335-1340; DOI: 10.1158/1055-9965.EPI-20-0122

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Serum Iodine and Breast Cancer Risk: A Prospective Nested Case–Control Study Stratified for Selenium Levels
Jonas Manjer, Malte Sandsveden and Signe Borgquist
Cancer Epidemiol Biomarkers Prev July 1 2020 (29) (7) 1335-1340; DOI: 10.1158/1055-9965.EPI-20-0122
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