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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Circulating Biomarker Score for Visceral Fat and Risks of Incident Colorectal and Postmenopausal Breast Cancer: The Multiethnic Cohort Adiposity Phenotype Study

Loïc Le Marchand, Lynne R. Wilkens, Ann M. Castelfranco, Kristine R. Monroe, Bruce S. Kristal, Iona Cheng, Gertraud Maskarinec, Meredith A. Hullar, Johanna W. Lampe, John A. Shepherd, Adrian Franke, Thomas Ernst and Unhee Lim
Loïc Le Marchand
1University of Hawaii Cancer Center, Honolulu, Hawaii.
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  • For correspondence: Loic@cc.Hawai.edu Lynne@cc.hawaii.edu ULim@cc.hawaii.edu
Lynne R. Wilkens
1University of Hawaii Cancer Center, Honolulu, Hawaii.
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  • For correspondence: Loic@cc.Hawai.edu Lynne@cc.hawaii.edu ULim@cc.hawaii.edu
Ann M. Castelfranco
2Bekesy Laboratory of Neurobiology, Pacific Biosciences Research Center, University of Hawaii, Honolulu, Hawaii.
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Kristine R. Monroe
3Keck School of Medicine, University of Southern California, Los Angeles, California.
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  • ORCID record for Kristine R. Monroe
Bruce S. Kristal
4Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
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  • ORCID record for Bruce S. Kristal
Iona Cheng
5School of Medicine, University of California–San Francisco, San Francisco, California.
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Gertraud Maskarinec
1University of Hawaii Cancer Center, Honolulu, Hawaii.
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Meredith A. Hullar
6Fred Hutchinson Cancer Research Center, Seattle, Washington.
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Johanna W. Lampe
6Fred Hutchinson Cancer Research Center, Seattle, Washington.
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John A. Shepherd
1University of Hawaii Cancer Center, Honolulu, Hawaii.
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Adrian Franke
1University of Hawaii Cancer Center, Honolulu, Hawaii.
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Thomas Ernst
7University of Maryland School of Medicine, Baltimore, Maryland.
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Unhee Lim
1University of Hawaii Cancer Center, Honolulu, Hawaii.
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  • For correspondence: Loic@cc.Hawai.edu Lynne@cc.hawaii.edu ULim@cc.hawaii.edu
DOI: 10.1158/1055-9965.EPI-19-1469 Published May 2020
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Abstract

Background: Visceral adipose tissue (VAT) may play a greater role than subcutaneous fat in increasing cancer risk but is poorly estimated in epidemiologic studies.

Methods: We developed a VAT prediction score by regression equations averaged across 100 least absolute shrinkage and selection operator models in a cross-sectional study of 1,801 older adults in the Multiethnic Cohort (MEC). The score was then used as proxy for VAT in case–control studies of postmenopausal breast (950 case–control pairs) and colorectal (831 case–control pairs) cancer in an independent sample in MEC. Abdominal MRI–derived VAT; circulating biomarkers of metabolic, hormonal, and inflammation dysfunctions; and ORs for incident cancer adjusted for BMI and other risk factors were assessed.

Results: The final score, composed of nine biomarkers, BMI, and height, explained 11% and 15% more of the variance in VAT than BMI alone in men and women, respectively. The area under the receiver operator curve for VAT >150 cm2 was 0.90 in men and 0.86 in women. The VAT score was associated with risk of breast cancer [OR (95% confidence interval [CI]) by increasing tertiles: 1.00, 1.09 (0.86–1.39), 1.48 (1.16–1.89); Ptrend = 0.002] but not with colorectal cancer (P = 0.84), although an association [1.00, 0.98 (0.68–1.39), 1.24 (0.88–1.76); Ptrend = 0.08] was suggested for this cancer after excluding cases that occurred within 7 years of blood draw (Pheterogeneity = 0.06).

Conclusions: The VAT score predicted risks of postmenopausal breast cancer and can be used for risk assessment in diverse populations.

Impact: These findings provide specific evidence for a role of VAT in breast cancer.

This article is featured in Highlights of This Issue, p. 887

Footnotes

  • Note: Supplementary data for this article are available at Cancer Epidemiology, Biomarkers & Prevention Online (http://cebp.aacrjournals.org/).

  • Cancer Epidemiol Biomarkers Prev 2020;29:966–73

  • Received November 23, 2019.
  • Revision received December 24, 2019.
  • Accepted February 25, 2020.
  • Published first March 4, 2020.
  • ©2020 American Association for Cancer Research.
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Cancer Epidemiology Biomarkers & Prevention: 29 (5)
May 2020
Volume 29, Issue 5
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Circulating Biomarker Score for Visceral Fat and Risks of Incident Colorectal and Postmenopausal Breast Cancer: The Multiethnic Cohort Adiposity Phenotype Study
Loïc Le Marchand, Lynne R. Wilkens, Ann M. Castelfranco, Kristine R. Monroe, Bruce S. Kristal, Iona Cheng, Gertraud Maskarinec, Meredith A. Hullar, Johanna W. Lampe, John A. Shepherd, Adrian Franke, Thomas Ernst and Unhee Lim
Cancer Epidemiol Biomarkers Prev May 1 2020 (29) (5) 966-973; DOI: 10.1158/1055-9965.EPI-19-1469

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Circulating Biomarker Score for Visceral Fat and Risks of Incident Colorectal and Postmenopausal Breast Cancer: The Multiethnic Cohort Adiposity Phenotype Study
Loïc Le Marchand, Lynne R. Wilkens, Ann M. Castelfranco, Kristine R. Monroe, Bruce S. Kristal, Iona Cheng, Gertraud Maskarinec, Meredith A. Hullar, Johanna W. Lampe, John A. Shepherd, Adrian Franke, Thomas Ernst and Unhee Lim
Cancer Epidemiol Biomarkers Prev May 1 2020 (29) (5) 966-973; DOI: 10.1158/1055-9965.EPI-19-1469
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