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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Glucosamine and Chondroitin Supplements and Risk of Colorectal Adenoma and Serrated Polyp

Dong Hoon Lee, Chao Cao, Xiaoyu Zong, Xuehong Zhang, Kelli O'Connell, Mingyang Song, Kana Wu, Mengmeng Du, Yin Cao, Edward L. Giovannucci and Elizabeth D. Kantor
Dong Hoon Lee
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
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  • For correspondence: dhlee@mail.harvard.edu
Chao Cao
2Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
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Xiaoyu Zong
2Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
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Xuehong Zhang
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
3Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
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Kelli O'Connell
4Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
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Mingyang Song
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
5Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
6Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
7Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
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Kana Wu
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
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Mengmeng Du
4Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
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Yin Cao
2Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
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Edward L. Giovannucci
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
3Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
4Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
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Elizabeth D. Kantor
4Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
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DOI: 10.1158/1055-9965.EPI-20-0805 Published December 2020
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Abstract

Background: Studies have shown an inverse association between use of glucosamine and chondroitin supplements and colorectal cancer risk. However, the association with the precursor lesion, colorectal adenoma and serrated polyp, has not been examined.

Methods: Analyses include 43,163 persons from the Nurses' Health Study (NHS), Health Professionals Follow-up Study (HPFS), and NHS2 who reported on glucosamine/chondroitin use in 2002 and who subsequently underwent ≥1 lower gastrointestinal endoscopy. By 2012, 5,715 conventional (2,016 high-risk) adenomas were detected, as were 4,954 serrated polyps. Multivariable logistic regression for clustered data was used to calculate OR and 95% confidence intervals (CI).

Results: Glucosamine/chondroitin use was inversely associated with high risk and any conventional adenoma in NHS and HPFS: in the pooled multivariable-adjusted model, glucosamine + chondroitin use at baseline was associated with a 26% (OR = 0.74; 95% CI, 0.60–0.90; Pheterogeneity = 0.23) and a 10% (OR = 0.90; 95% CI, 0.81–0.99; Pheterogeneity = 0.36) lower risk of high-risk adenoma and overall conventional adenoma, respectively. However, no association was observed in NHS2, a study of younger women (high-risk adenoma: OR = 1.09; 95% CI, 0.82–1.45; overall conventional adenoma: OR = 1.00; 95% CI, 0.86–1.17), and effect estimates pooled across all three studies were not significant (high-risk: OR = 0.83; 95% CI, 0.63–1.10; Pheterogeneity = 0.03; overall conventional adenoma: OR = 0.93; 95% CI, 0.85–1.02; Pheterogeneity = 0.31). No associations were observed for serrated polyps.

Conclusions: Glucosamine/chondroitin use was associated with lower risks of high-risk and overall conventional adenoma in older adults; however, this association did not hold in younger women, or for serrated polyps.

Impact: Our study suggests that glucosamine and chondroitin may act on early colorectal carcinogenesis in older adults.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Epidemiology, Biomarkers & Prevention Online (http://cebp.aacrjournals.org/).

  • Cancer Epidemiol Biomarkers Prev 2020;29:2693–701

  • Received May 24, 2020.
  • Revision received August 17, 2020.
  • Accepted September 22, 2020.
  • Published first October 14, 2020.
  • ©2020 American Association for Cancer Research.
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Cancer Epidemiology Biomarkers & Prevention: 29 (12)
December 2020
Volume 29, Issue 12
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Glucosamine and Chondroitin Supplements and Risk of Colorectal Adenoma and Serrated Polyp
Dong Hoon Lee, Chao Cao, Xiaoyu Zong, Xuehong Zhang, Kelli O'Connell, Mingyang Song, Kana Wu, Mengmeng Du, Yin Cao, Edward L. Giovannucci and Elizabeth D. Kantor
Cancer Epidemiol Biomarkers Prev December 1 2020 (29) (12) 2693-2701; DOI: 10.1158/1055-9965.EPI-20-0805

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Glucosamine and Chondroitin Supplements and Risk of Colorectal Adenoma and Serrated Polyp
Dong Hoon Lee, Chao Cao, Xiaoyu Zong, Xuehong Zhang, Kelli O'Connell, Mingyang Song, Kana Wu, Mengmeng Du, Yin Cao, Edward L. Giovannucci and Elizabeth D. Kantor
Cancer Epidemiol Biomarkers Prev December 1 2020 (29) (12) 2693-2701; DOI: 10.1158/1055-9965.EPI-20-0805
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