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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Noninvasive Diagnostics for Early Detection of Lung Cancer: Challenges and Potential with a Focus on Changes in DNA Methylation

Maria Farooq and James G. Herman
Maria Farooq
1Department of Medicine, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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James G. Herman
1Department of Medicine, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
2UPMC Hillman Comprehensive Cancer Center, Pittsburgh, Pennsylvania.
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  • For correspondence: hermanj3@upmc.edu
DOI: 10.1158/1055-9965.EPI-20-0704 Published December 2020
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Article Information

Volume 29, Issue 12, pp. 2416-2422

DOI 
https://doi.org/10.1158/1055-9965.EPI-20-0704
PubMed 
33148791

Published By 
American Association for Cancer Research
Print ISSN 
1055-9965
Online ISSN 
1538-7755
History 
  • Received May 8, 2020
  • Revision received August 20, 2020
  • Accepted October 13, 2020
  • Published first November 4, 2020.

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  • Previous version (November 4, 2020 - 05:44).
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©2020 American Association for Cancer Research.

Author Information

  1. Maria Farooq1 and
  2. James G. Herman1,2,*
  1. 1Department of Medicine, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  2. 2UPMC Hillman Comprehensive Cancer Center, Pittsburgh, Pennsylvania.
  1. ↵*Corresponding Author:
    James G. Herman, University of Pittsburgh 5117 Centre Avenue, Suite 2.18, Pittsburgh, PA 15213. Phone: 412-623-7769; Fax: 412-623-7768; E-mail: hermanj3{at}upmc.edu
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Cancer Epidemiology Biomarkers & Prevention: 29 (12)
December 2020
Volume 29, Issue 12
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Noninvasive Diagnostics for Early Detection of Lung Cancer: Challenges and Potential with a Focus on Changes in DNA Methylation
Maria Farooq and James G. Herman
Cancer Epidemiol Biomarkers Prev December 1 2020 (29) (12) 2416-2422; DOI: 10.1158/1055-9965.EPI-20-0704

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Noninvasive Diagnostics for Early Detection of Lung Cancer: Challenges and Potential with a Focus on Changes in DNA Methylation
Maria Farooq and James G. Herman
Cancer Epidemiol Biomarkers Prev December 1 2020 (29) (12) 2416-2422; DOI: 10.1158/1055-9965.EPI-20-0704
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  • Article
    • Abstract
    • Introduction
    • Potential Analytes as Biomarkers for Lung Cancer Detection
    • Clinical Applications of Liquid Biopsy
    • Current Landscape for Noninvasive Biomarkers
    • Sputum Detection
    • Plasma Detection
    • Methylation-Based Assay Design
    • Limitations of Current Studies and Solutions
    • Future Directions
    • Authors' Disclosures
    • Acknowledgments
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