Article Figures & Data
Tables
- Table 1.
Demographic and clinical factors by case–control status among women with carcinoma in situ of the breast
Study participants, N (%) First-degree family history of breast cancer Characteristics No (n = 1,094) Yes (n = 439) Age at first breast cancer diagnosis <50 367 (33.6) 164 (37.4) 50–59 386 (35.3) 144 (32.8) 60–69 225 (20.6) 92 (21.0) 70–79 116 (10.6) 39 (8.9) Year of first breast cancer diagnosis 1995–1997 231 (21.1) 103 (23.5) 1998–2000 247 (22.6) 112 (25.5) 2001–2004 311 (28.4) 105 (23.9) 2005–2013 305 (27.9) 119 (27.1) Race/ethnicity Non-Hispanic white 976 (89.2) 403 (91.8) Hispanic white 22 (2.0) 10 (2.3) Black 22 (2.0) 5 (1.1) Asian/Pacific Islander 57 (5.2) 16 (3.6) Native American 16 (1.5) 5 (1.1) Unknown 1 0 Body mass index at first breast cancer diagnosis <25 499 (47.3) 197 (46.9) 25–<30 309 (29.3) 128 (30.5) ≥30 247 (23.4) 95 (22.6) Unknown 39 19 Body mass index at reference <25 445 (43.8) 174 (42.2) 25-<30 308 (30.3) 144 (35.0) ≥30 263 (25.9) 94 (22.8) Unknown 78 27 Smoking status at first breast cancer diagnosis Never smoker 594 (56.0) 243 (57.2) Former smoker 355 (33.5) 137 (32.2) Current smoker 111 (10.5) 45 (10.6) Unknown 34 14 Grade of first tumor 1 – well differentiated 30 (3.8) 10 (3.3) 2 – moderately differentiated 227 (28.6) 92 (30.0) 3 – poorly differentiated 252 (31.7) 88 (28.7) 4 – undifferentiated 285 (35.9) 117 (38.1) Unknown 300 132 Radiation treatment for first breast cancer Yes 529 (48.4) 192 (43.7) No 565 (51.7) 247 (56.3) Surgery for first breast cancer Biopsy only 36 (3.3) 20 (4.6) Lumpectomy without nodal dissection 751 (68.7) 303 (69.0) Lumpectomy with sentinal node biopsy 55 (5.0) 20 (4.6) Lumpectomy with nodal dissection 45 (4.1) 9 (2.1) Mastectomy 207 (18.9) 87 (19.8) Laterality of second breast cancer Ipsilateral 154 (42.2) 85 (48.9) Contralateral 210 (57.5) 86 (49.4) Bilateral 1 (0.3) 3 (1.7) Menopausal status at first breast cancer diagnosis Pre/Peri-menopausal 417 (39.2) 183 (43.5) Postmenopausal 646 (60.8) 238 (56.5) Unknown 31 18 Menopausal status at reference Pre/Peri-menopausal 191 (18.2) 91 (21.9) Postmenopausal 856 (81.8) 324 (78.1) Unknown 47 24 - Table 2.
Relationship between family history of breast cancer and risk of second breast cancer among women with carcinoma in situ of the breast
Controls All cases Invasive cases n (%) n (%) OR (95% CI)a n (%) OR (95% CI)a DCIS and LCIS (n = 1,533) First-degree family history of breast cancer No 729 (73.3) 365 (67.7) 1 [Ref] 247 (67.1) 1 [Ref] Yes 265 (26.7) 174 (32.3) 1.33 (1.05–1.69) 121 (32.9) 1.37 (1.02–1.84) No. of first-degree relatives with breast cancer 0 729 (73.6) 365 (67.8) 1 [Ref] 247 (67.1) 1 [Ref] 1 224 (22.6) 141 (26.2) 1.25 (0.96–1.62) 100 (27.2) 1.33 (0.97–1.82) 2+ 37 (3.7) 32 (6.0) 1.94 (1.15–3.28) 21 (5.7) 1.87 (0.97–3.60) Age at diagnosis of first-degree family member No history 729 (74.5) 365 (69.0) 1 [Ref] 247 (68.4) 1 [Ref] ≥50 176 (18.0) 98 (18.5) 1.11 (0.83–1.49) 66 (18.3) 1.20 (0.84–1.73) <50 73 (7.5) 66 (12.5) 1.78 (1.24–2.57) 48 (13.3) 1.68 (1.09–2.58) DCIS only (n = 1,333) First-degree family history of breast cancer No 638 (73.3) 318 (68.8) 1 [Ref] 213 (68.1) 1 [Ref] Yes 233 (26.8) 144 (31.2) 1.26 (0.97–1.63) 100 (32.0) 1.30 (0.94–1.79) No. of first-degree relatives with breast cancer 0 638 (73.5) 318 (69.0) 1 [Ref] 213 (68.1) 1 [Ref] 1 195 (22.5) 115 (25.0) 1.18 (0.89–1.56) 81 (25.9) 1.25 (0.88–1.77) 2+ 35 (4.0) 28 (6.1) 1.78 (1.02–3.10) 19 (6.1) 1.73 (0.87–3.43) Age at diagnosis of first-degree family member No history 638 (74.5) 318 (70.2) 1 [Ref] 213 (69.4) 1 [Ref] ≥50 152 (17.7) 82 (18.1) 1.10 (0.80–1.50) 56 (18.2) 1.23 (0.83–1.81) <50 67 (7.8) 53 (11.7) 1.56 (1.05–2.33) 38 (12.4) 1.42 (0.89–2.28) NOTE: Five participants missing information on number of first-degree relatives and 26 missing information on age of family member.
↵aModels were implicitly adjusted for matching factors, no further adjustment.
- Table 3.
Relationship between family history and risk of second breast cancer stratified by menopausal status among women with carcinoma in situ of the breast
Pre-/Perimenopausal Postmenopausal Controls All cases Controls All cases n (%) n (%) OR (95% CI)a n (%) n (%) OR (95% CI)a First-degree family history of breast cancer No 270 (70.5) 147 (67.7) 1 [Ref] 438 (75.8) 208 (68.0) 1 [Ref] Yes 113 (29.5) 70 (32.3) 1.15 (0.77–1.71) 140 (24.2) 98 (32.0) 1.56 (1.13–2.16) No. of first-degree relatives with breast cancer 0 270 (70.9) 147 (67.7) 1 [Ref] 438 (76.0) 208 (68.2) 1 [Ref] 1 99 (26.0) 57 (26.3) 1.02 (0.66–1.60) 115 (20.0) 80 (26.2) 1.52 (1.07–2.17) 2+ 12 (3.2) 13 (6.0) 2.30 (0.97–5.48) 23 (4.0) 17 (5.6) 1.75 (0.88–3.49) Age at diagnosis of first-degree family member No history 270 (71.2) 147 (67.7) 1 [Ref] 438 (77.3) 208 (70.3) 1 [Ref] ≥50 76 (20.1) 37 (17.1) 0.82 (0.49–1.39) 91 (16.1) 57 (19.3) 1.39 (0.93–2.06) <50 33 (8.7) 33 (15.2) 2.02 (1.14–3.59) 38 (6.7) 31 (10.5) 1.80 (1.03–3.13) ↵aModels were implicitly adjusted for matching factors, no further adjustment.
- Table 4.
Relationship between family history and risk of second breast cancer stratified by ER status of the second breast cancer among women with carcinoma in situ of the breast
ER+ ER− Invasive cases Invasive cases n (%) OR (95% CI)a n (%) OR (95% CI)a First-degree family history of breast cancer No 192 (66.0) 1 [Ref] 46 (73.0) 1 [Ref] Yes 99 (34.0) 1.49 (1.07–2.07) 17 (27.0) 1.00 (0.49–2.03) No. of first-degree relatives with breast cancer 0 192 (66.0) 1 [Ref] 46 (73.0) 1 [Ref] 1 79 (27.2) 1.42 (0.99–2.04) 16 (25.4) 1.04 (0.51–2.16) 2+ 20 (6.9) 2.04 (1.03–4.04) 1 (1.6) 0.79 (0.07–8.97) Age at diagnosis of first-degree relative No history 192 (67.4) 1 [Ref] 46 (74.2) 1 [Ref] ≥50 54 (19.0) 1.22 (0.82–1.83) 10 (16.1) 1.45 (0.59–3.54) <50 39 (13.7) 2.03 (1.24–3.31) 6 (9.7) 0.67 (0.24–1.86) NOTE: 14 cases with second primary invasive breast cancer missing ER status for second tumor.
↵aModels were implicitly adjusted for matching factors, no further adjustment.
March 2018
Volume 27, Issue 3
Volume 27, Issue 3
Family History and Risk of Second Primary Breast Cancer after In Situ Breast Carcinoma
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