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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Research Articles

Family History and Risk of Second Primary Breast Cancer after In Situ Breast Carcinoma

Michelle L. Baglia, Mei-Tzu C. Tang, Kathleen E. Malone, Peggy Porter and Christopher I. Li
Michelle L. Baglia
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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  • For correspondence: mbaglia@fredhutch.org
Mei-Tzu C. Tang
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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Kathleen E. Malone
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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Peggy Porter
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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Christopher I. Li
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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DOI: 10.1158/1055-9965.EPI-17-0837 Published March 2018
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Tables

  • Table 1.

    Demographic and clinical factors by case–control status among women with carcinoma in situ of the breast

    Study participants, N (%)
    First-degree family history of breast cancer
    CharacteristicsNo (n = 1,094)Yes (n = 439)
    Age at first breast cancer diagnosis
     <50367 (33.6)164 (37.4)
     50–59386 (35.3)144 (32.8)
     60–69225 (20.6)92 (21.0)
     70–79116 (10.6)39 (8.9)
    Year of first breast cancer diagnosis
     1995–1997231 (21.1)103 (23.5)
     1998–2000247 (22.6)112 (25.5)
     2001–2004311 (28.4)105 (23.9)
     2005–2013305 (27.9)119 (27.1)
    Race/ethnicity
     Non-Hispanic white976 (89.2)403 (91.8)
     Hispanic white22 (2.0)10 (2.3)
     Black22 (2.0)5 (1.1)
     Asian/Pacific Islander57 (5.2)16 (3.6)
     Native American16 (1.5)5 (1.1)
     Unknown10
    Body mass index at first breast cancer diagnosis
     <25499 (47.3)197 (46.9)
     25–<30309 (29.3)128 (30.5)
     ≥30247 (23.4)95 (22.6)
     Unknown3919
    Body mass index at reference
     <25445 (43.8)174 (42.2)
     25-<30308 (30.3)144 (35.0)
     ≥30263 (25.9)94 (22.8)
     Unknown7827
    Smoking status at first breast cancer diagnosis
     Never smoker594 (56.0)243 (57.2)
     Former smoker355 (33.5)137 (32.2)
     Current smoker111 (10.5)45 (10.6)
     Unknown3414
    Grade of first tumor
     1 – well differentiated30 (3.8)10 (3.3)
     2 – moderately differentiated227 (28.6)92 (30.0)
     3 – poorly differentiated252 (31.7)88 (28.7)
     4 – undifferentiated285 (35.9)117 (38.1)
     Unknown300132
    Radiation treatment for first breast cancer
     Yes529 (48.4)192 (43.7)
     No565 (51.7)247 (56.3)
    Surgery for first breast cancer
     Biopsy only36 (3.3)20 (4.6)
     Lumpectomy without nodal dissection751 (68.7)303 (69.0)
     Lumpectomy with sentinal node biopsy55 (5.0)20 (4.6)
     Lumpectomy with nodal dissection45 (4.1)9 (2.1)
     Mastectomy207 (18.9)87 (19.8)
    Laterality of second breast cancer
     Ipsilateral154 (42.2)85 (48.9)
     Contralateral210 (57.5)86 (49.4)
     Bilateral1 (0.3)3 (1.7)
    Menopausal status at first breast cancer diagnosis
     Pre/Peri-menopausal417 (39.2)183 (43.5)
     Postmenopausal646 (60.8)238 (56.5)
     Unknown3118
    Menopausal status at reference
     Pre/Peri-menopausal191 (18.2)91 (21.9)
     Postmenopausal856 (81.8)324 (78.1)
     Unknown4724
  • Table 2.

    Relationship between family history of breast cancer and risk of second breast cancer among women with carcinoma in situ of the breast

    ControlsAll casesInvasive cases
    n (%)n (%)OR (95% CI)an (%)OR (95% CI)a
    DCIS and LCIS (n = 1,533)
     First-degree family history of breast cancer
      No729 (73.3)365 (67.7)1 [Ref]247 (67.1)1 [Ref]
      Yes265 (26.7)174 (32.3)1.33 (1.05–1.69)121 (32.9)1.37 (1.02–1.84)
     No. of first-degree relatives with breast cancer
      0729 (73.6)365 (67.8)1 [Ref]247 (67.1)1 [Ref]
      1224 (22.6)141 (26.2)1.25 (0.96–1.62)100 (27.2)1.33 (0.97–1.82)
      2+37 (3.7)32 (6.0)1.94 (1.15–3.28)21 (5.7)1.87 (0.97–3.60)
     Age at diagnosis of first-degree family member
      No history729 (74.5)365 (69.0)1 [Ref]247 (68.4)1 [Ref]
      ≥50176 (18.0)98 (18.5)1.11 (0.83–1.49)66 (18.3)1.20 (0.84–1.73)
      <5073 (7.5)66 (12.5)1.78 (1.24–2.57)48 (13.3)1.68 (1.09–2.58)
    DCIS only (n = 1,333)
     First-degree family history of breast cancer
      No638 (73.3)318 (68.8)1 [Ref]213 (68.1)1 [Ref]
      Yes233 (26.8)144 (31.2)1.26 (0.97–1.63)100 (32.0)1.30 (0.94–1.79)
     No. of first-degree relatives with breast cancer
      0638 (73.5)318 (69.0)1 [Ref]213 (68.1)1 [Ref]
      1195 (22.5)115 (25.0)1.18 (0.89–1.56)81 (25.9)1.25 (0.88–1.77)
      2+35 (4.0)28 (6.1)1.78 (1.02–3.10)19 (6.1)1.73 (0.87–3.43)
     Age at diagnosis of first-degree family member
      No history638 (74.5)318 (70.2)1 [Ref]213 (69.4)1 [Ref]
      ≥50152 (17.7)82 (18.1)1.10 (0.80–1.50)56 (18.2)1.23 (0.83–1.81)
      <5067 (7.8)53 (11.7)1.56 (1.05–2.33)38 (12.4)1.42 (0.89–2.28)
    • NOTE: Five participants missing information on number of first-degree relatives and 26 missing information on age of family member.

    • ↵aModels were implicitly adjusted for matching factors, no further adjustment.

  • Table 3.

    Relationship between family history and risk of second breast cancer stratified by menopausal status among women with carcinoma in situ of the breast

    Pre-/PerimenopausalPostmenopausal
    ControlsAll casesControlsAll cases
    n (%)n (%)OR (95% CI)an (%)n (%)OR (95% CI)a
    First-degree family history of breast cancer
     No270 (70.5)147 (67.7)1 [Ref]438 (75.8)208 (68.0)1 [Ref]
     Yes113 (29.5)70 (32.3)1.15 (0.77–1.71)140 (24.2)98 (32.0)1.56 (1.13–2.16)
    No. of first-degree relatives with breast cancer
     0270 (70.9)147 (67.7)1 [Ref]438 (76.0)208 (68.2)1 [Ref]
     199 (26.0)57 (26.3)1.02 (0.66–1.60)115 (20.0)80 (26.2)1.52 (1.07–2.17)
     2+12 (3.2)13 (6.0)2.30 (0.97–5.48)23 (4.0)17 (5.6)1.75 (0.88–3.49)
    Age at diagnosis of first-degree family member
     No history270 (71.2)147 (67.7)1 [Ref]438 (77.3)208 (70.3)1 [Ref]
     ≥5076 (20.1)37 (17.1)0.82 (0.49–1.39)91 (16.1)57 (19.3)1.39 (0.93–2.06)
     <5033 (8.7)33 (15.2)2.02 (1.14–3.59)38 (6.7)31 (10.5)1.80 (1.03–3.13)
    • ↵aModels were implicitly adjusted for matching factors, no further adjustment.

  • Table 4.

    Relationship between family history and risk of second breast cancer stratified by ER status of the second breast cancer among women with carcinoma in situ of the breast

    ER+ER−
    Invasive casesInvasive cases
    n (%)OR (95% CI)an (%)OR (95% CI)a
    First-degree family history of breast cancer
     No192 (66.0)1 [Ref]46 (73.0)1 [Ref]
     Yes99 (34.0)1.49 (1.07–2.07)17 (27.0)1.00 (0.49–2.03)
    No. of first-degree relatives with breast cancer
     0192 (66.0)1 [Ref]46 (73.0)1 [Ref]
     179 (27.2)1.42 (0.99–2.04)16 (25.4)1.04 (0.51–2.16)
     2+20 (6.9)2.04 (1.03–4.04)1 (1.6)0.79 (0.07–8.97)
    Age at diagnosis of first-degree relative
     No history192 (67.4)1 [Ref]46 (74.2)1 [Ref]
     ≥5054 (19.0)1.22 (0.82–1.83)10 (16.1)1.45 (0.59–3.54)
     <5039 (13.7)2.03 (1.24–3.31)6 (9.7)0.67 (0.24–1.86)
    • NOTE: 14 cases with second primary invasive breast cancer missing ER status for second tumor.

    • ↵aModels were implicitly adjusted for matching factors, no further adjustment.

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Cancer Epidemiology Biomarkers & Prevention: 27 (3)
March 2018
Volume 27, Issue 3
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Family History and Risk of Second Primary Breast Cancer after In Situ Breast Carcinoma
Michelle L. Baglia, Mei-Tzu C. Tang, Kathleen E. Malone, Peggy Porter and Christopher I. Li
Cancer Epidemiol Biomarkers Prev March 1 2018 (27) (3) 315-320; DOI: 10.1158/1055-9965.EPI-17-0837

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Family History and Risk of Second Primary Breast Cancer after In Situ Breast Carcinoma
Michelle L. Baglia, Mei-Tzu C. Tang, Kathleen E. Malone, Peggy Porter and Christopher I. Li
Cancer Epidemiol Biomarkers Prev March 1 2018 (27) (3) 315-320; DOI: 10.1158/1055-9965.EPI-17-0837
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