Article Figures & Data
Tables
- Table 1.
Selected characteristics [medians (interquartile range) or percent] for renal cell carcinoma case and control subjects in the CPS-II cohort
Controls Cases Characteristics (n = 87) (n = 87) Pa Age, y 70.4 (65.7–75.4) 70.8 (66.5–75.4) Matched Male (%) 64.4 64.4 Matched Race White 97.7 97.7 Matched BMIb (kg/m2) 25.1 (22.9–28.1) 26.5 (24.0–28.7) 0.10 Smoking statusb Never 47.5 35.8 0.31 Former 50.0 61.7 Current 2.5 2.5 History of diabetesb (%) 10.3 17.2 0.19 History of kidney failurec (%) 0.0 1.2 1.00 Physical activityb (MET-h/wk) 14.0 (7.0–24.5) 14.0 (7.0–24.9) 0.89 College graduatec (%) 47.7 52.9 0.17 Intake/dayb Total energy (kcal) 1,788 (1,488–2,147) 1,778 (1,437–2,082) 0.88 Dietary vitamin D (IU) 188 (148–283) 179 (128–292) 0.87 Dietary calcium (mg) 730 (583–1,112) 744 (563–1,071) 0.94 Alcohol (drinks) 0.10 (0–0.72) 0.10 (0–0.75) 0.98 Use of dietary supplementsb (%) Vitamin D 17.7 6.9 0.09 Calcium 38.2 36.1 0.80 Family history of kidney cancerc 2.3 0.0 0.50 Family history of any other cancerb 65.5 58.6 0.35 - Table 2.
Selected characteristics [medians (interquartile range) or percent] by quartile of circulating DBP concentration in the CPS-II cohort
Q1 Q2 Q3 Q4 Characteristics (<272 μg/mL) (272–<294 μg/mL) (294–<334 μg/mL) (≥334 μg/mL) Pa Age, y 71.6 (66.1–75.9) 72.5 (68.3–76.0) 70.1 (65.4–74.9) 67.8 (64.0–73.8) 0.06 Male (%) 74.0 72.6 64.1 38.2 0.003 Race (%) White 96.0 98.0 97.4 100.0 0.69 BMIb (kg/m2) 27.3 (23.6–29.6) 24.8 (23.0–27.4) 25.1 (22.1–27.5) 25.4 (23.2–28.2) 0.09 Smoking statusb (%) Never 37.0 42.2 36.8 53.1 0.52 Former 63.0 55.6 57.9 43.8 Current 0.0 2.2 5.3 3.1 History of diabetesb (%) 22.0 13.7 12.8 2.9 0.10 History of kidney failurec (%) 0 0 0 2.9 0.25 Physical activityb (MET-h/wk) 14.0 (7.0–26.5) 14.0 (7.0–24.5) 14.0 (7.0–24.0) 13.9 (7.0–29.0) 0.89 College graduatec (%) 62.0 51.0 38.5 45.5 0.77 Intake/dayb Total energy (kcal) 1,881 (1,445–2,254) 1,842 (1,538–2,159) 1,719 (1,378–2,082) 1,628 (1,495–2,137) 0.56 Dietary vitamin D (IU) 178 (141–283) 183 (114–303) 167 (125–283) 188 (160–220) 0.85 Dietary calcium (mg) 738 (630–945) 786 (539–1,144) 671 (500–1,133) 742 (633–1,115) 0.81 Alcohol (drinks) 0.17 (0–0.87) 0.20 (0–1.13) 0.07 (0–0.37) 0.07 (0–0.60) 0.38 Use of dietary supplementsb (%) Vitamin D 11.9 9.8 6.5 22.3 0.29 Calcium 36.6 25.6 42.9 48.3 0.21 Family history of kidney cancerc (%) 0 0 2.6 2.9 0.42 Family history of any other cancerb (%) 60.0 51.0 64.1 79.4 0.07 - Table 3.
Association between circulating DBP concentration and risk of renal cell carcinoma in the CPS-II cohort
Q1 Q2 Q3 Q4 (<272 μg/mL) (272–<294 μg/mL) (294–<334 μg/mL) (≥334 μg/mL) Ptrend #Cases/#controls 28/22 29/22 17/22 13/21 OR (95% CI)a 1.0 (ref) 0.86 (0.40–1.88) 0.42 (0.16–1.12) 0.29 (0.09–0.91) 0.02 OR (95% CI)b 1.0 (ref) 0.93 (0.41–2.11) 0.42 (0.15–1.15) 0.33 (0.10–1.06) 0.03 OR (95% CI)c 1.0 (ref) 0.98 (0.42–2.31) 0.39 (0.14–1.08) 0.36 (0.11–1.22) 0.048 OR (95% CI)d 1.0 (ref) 1.00 (0.42–2.38) 0.36 (0.13–1.05) 0.33 (0.09–1.16) 0.041 ↵aConditioned on matching factors (age, sex, race, date of blood collection).
↵bConditioned on matching factors (age, sex, race, date of blood collection); additionally adjusted for BMI.
↵cConditioned on matching factors (age, sex, race, date of blood collection); additionally adjusted for BMI, supplemental vitamin D use, and family history of any cancer.
↵dConditioned on matching factors (age, sex, race, date of blood collection); additionally adjusted for BMI, supplemental vitamin D use, family history of any cancer, and smoking status.