Article Figures & Data
Figures
- Figure 1.
A, Kaplan–Meier curves for sarcopenia and all-cause mortality. B, Kaplan–Meier curves for body composition phenotypes and all-cause mortality.
- Figure 2.
Restricted cubic splines for body composition and overall mortality, by sex. Reference is sex-specific median; graphs have 4 knots and are truncated at 1st and 99th percentiles; adjusted for age, stage, site, treatment, and partitioned BMI. SMI graphs additionally adjusted for total adiposity in tertiles; total adiposity graphs adjusted for muscle in tertiles.
- Figure 3.
A, Restricted cubic spline for BMI has 4 knots and is adjusted for age, sex, race, stage, grade, site, treatment, prediagnosis BMI, smoking, and physical activity. Reference value is the overall median (27.2); test for curvature P < 0.0001; overall significance P < 0.0001. B, Histogram for body composition phenotypes by BMI.
Tables
- Table 1.
Characteristics of the cohort, by sarcopenia status
Total Sarcopenica Not sarcopenic N = 3,262 N = 1,383 N = 1,879 n Row% n Row% n Row% P Age at diagnosis, y Mean (SD) 62.6 (11.4) 66.4 (10.4) 59.8 (11.3) <0.0001 Age at diagnosis, y <60 1238 100.0 332 26.8 906 73.2 <0.0001 60–<70 941 100.0 420 44.6 521 55.4 ≥70 1083 100.0 631 58.3 452 41.7 Sex Male 1634 100.0 740 45.3 894 54.7 0.001 Female 1628 100.0 643 39.5 985 60.5 Race/Ethnicity White 2118 100.0 960 45.3 1158 54.7 <0.0001 Black 234 100.0 66 28.2 168 71.8 Hispanic 365 100.0 112 30.7 253 69.3 Asian/PI 520 100.0 239 46.0 281 54.0 Other 21 100.0 5 23.8 16 76.2 AJCC Stage I 979 100.0 377 38.5 602 61.5 0.003 II or III 2283 100.0 1006 44.1 1277 55.9 Site of cancer Rectal 947 100.0 353 37.3 594 62.7 <0.0001 Colon 2315 100.0 1030 44.5 1285 55.5 Weight change in 18 mo prediagnosis Stable 1150 100.0 484 42.1 666 57.9 0.22 ≥5% loss 548 100.0 255 46.5 293 53.5 ≥5% gain 137 100.0 60 43.8 77 56.2 Smoking status Never 1516 100.0 602 39.7 914 60.3 0.01 Former 1347 100.0 608 45.1 739 54.9 Current 396 100.0 173 43.7 223 56.3 Charlson comorbidity score 0 1770 100.0 744 42.0 1026 58.0 0.48 1–2 946 100.0 416 44.0 530 56.0 ≥3 321 100.0 144 44.9 177 55.1 Neutrophil/Lymphocyte ratio <5 2250 100.0 880 39.1 1370 60.9 <0.0001 ≥5 919 100.0 466 50.7 453 49.3 ↵aThe SMI cut points for sarcopenia for men and women were normal/overweight and obese. The normal and overweight points for men and women were <52.3 and <38.6, respectively, and the obese points were <54.3 and <46.6, respectively.
- Table 2.
Body composition and mortality
Overall mortality CRCsM At risk No. of events HR (95% CI) No. of events HR (95% CI) Sarcopenic No 1,879 362 Referent 200 Referent Yes 1,383 426 1.27 (1.09–1.48) 233 1.46 (1.19–1.79) Muscle, cm2 Low tertile 1 1,086 328 1.32 (1.07–1.64) 176 1.54 (1.16–2.05) Middle tertile 2 1,088 249 1.13 (0.93–1.37) 135 1.19 (0.92–1.55) High tertile 3 1,088 211 Referent 122 Referent Ptrend 0.01 0.003 Body composition phenotypes Normal 1,251 239 Referent 134 Referent Low muscle 925 272 1.33 (1.10–1.61) 144 1.46 (1.13–1.88) High adiposity 925 221 1.21 (1.01–1.46) 123 1.28 (1.00–1.64) Low muscle and high adiposity 161 56 1.40 (1.03–1.90) 32 1.79 (1.20–2.67) Body composition phenotypes, among men Normal 637 130 Referent 78 Referent Low muscle 453 137 1.34 (1.02–1.74) 68 1.30 (0.91–1.87) High adiposity 452 110 1.13 (0.87–1.46) 57 1.08 (0.76–1.52) Low muscle and high adiposity 92 30 1.25 (0.82–1.90) 16 1.33 (0.76–2.34) Body composition phenotypes, among women Normal 614 109 Referent 56 Referent Low muscle 472 135 1.38 (1.06–1.81) 76 1.69 (1.17–2.45) High adiposity 473 111 1.30 (0.99–1.71) 66 1.56 (1.09–2.25) Low muscle and high adiposity 69 26 1.64 (1.05–2.57) 16 2.62 (1.48–4.65) NOTE: Models adjusted for age at diagnosis (continuous), sex (ref = Men), race (ref = white), stage (ref = I), chemotherapy (ref = no), radiation (ref = no), site of cancer (ref = rectal), and partitioned BMI. Sarcopenia and muscle models adjusted for total adiposity in tertiles (ref = low).
Supplementary Data
- Supplemental Tables 1-3 - Supplemental Tables 1-3
Volume 26, Issue 7
