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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Alcohol Consumption and the Risk of Colorectal Cancer for Mismatch Repair Gene Mutation Carriers

S. Ghazaleh Dashti, Daniel D. Buchanan, Harindra Jayasekara, Driss Ait Ouakrim, Mark Clendenning, Christophe Rosty, Ingrid M. Winship, Finlay A. Macrae, Graham G. Giles, Susan Parry, Graham Casey, Robert W. Haile, Steven Gallinger, Loïc Le Marchand, Stephen N. Thibodeau, Noralane M. Lindor, Polly A. Newcomb, John D. Potter, John A. Baron, John L. Hopper, Mark A. Jenkins and Aung Ko Win
S. Ghazaleh Dashti
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
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Daniel D. Buchanan
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
2Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia.
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Harindra Jayasekara
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
3Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
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Driss Ait Ouakrim
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
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Mark Clendenning
2Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia.
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Christophe Rosty
2Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia.
4School of Medicine, University of Queensland, Herston, Queensland, Australia.
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Ingrid M. Winship
5Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
6Genetic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia.
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Finlay A. Macrae
5Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
6Genetic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia.
7Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Parkville, Victoria, Australia.
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Graham G. Giles
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
3Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
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Susan Parry
8New Zealand Familial Gastrointestinal Cancer Service, Auckland Hospital, Auckland, New Zealand.
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Graham Casey
9Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
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Robert W. Haile
10Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University, California.
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Steven Gallinger
11Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
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Loïc Le Marchand
12Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
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Stephen N. Thibodeau
13Molecular Genetics Laboratory, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
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Noralane M. Lindor
14Department of Health Science Research, Mayo Clinic Arizona, Scottsdale, Arizona.
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Polly A. Newcomb
15Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
16School of Public Health, University of Washington, Seattle, Washington.
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John D. Potter
15Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
16School of Public Health, University of Washington, Seattle, Washington.
17Centre for Public Health Research, Massey University, Wellington, New Zealand.
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John A. Baron
18Department of Medicine, University of North Carolina, Chapel Hill, North Carolina.
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John L. Hopper
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
19Department of Epidemiology and Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea.
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Mark A. Jenkins
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
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Aung Ko Win
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
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  • For correspondence: awin@unimelb.edu.au
DOI: 10.1158/1055-9965.EPI-16-0496 Published March 2017
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Abstract

Background: People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For these high-risk people, study findings of the relationship between alcohol consumption and colorectal cancer risk have been inconclusive.

Methods: 1,925 MMR gene mutations carriers recruited into the Colon Cancer Family Registry who had completed a questionnaire on lifestyle factors were included. Weighted Cox proportional hazard regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between alcohol consumption and colorectal cancer.

Results: Colorectal cancer was diagnosed in 769 carriers (40%) at a mean (SD) age of 42.6 (10.3) years. Compared with abstention, ethanol consumption from any alcoholic beverage up to 14 g/day and >28 g/day was associated with increased colorectal cancer risk (HR, 1.50; 95% CI, 1.09–2.07 and 1.69; 95% CI, 1.07–2.65, respectively; Ptrend = 0.05), and colon cancer risk (HR, 1.78; 95% CI, 1.27–2.49 and 1.94; 95% CI, 1.19–3.18, respectively; Ptrend = 0.02). However, there was no clear evidence for an association with rectal cancer risk. Also, there was no evidence for associations between consumption of individual alcoholic beverage types (beer, wine, spirits) and colorectal, colon, or rectal cancer risk.

Conclusions: Our data suggest that alcohol consumption, particularly more than 28 g/day of ethanol (∼2 standard drinks of alcohol in the United States), is associated with increased colorectal cancer risk for MMR gene mutation carriers.

Impact: Although these data suggested that alcohol consumption in MMR carriers was associated with increased colorectal cancer risk, there was no evidence of a dose-response, and not all types of alcohol consumption were associated with increased risk. Cancer Epidemiol Biomarkers Prev; 26(3); 366–75. ©2016 AACR.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Epidemiology, Biomarkers & Prevention Online (http://cebp.aacrjournals.org/).

  • Received June 15, 2016.
  • Revision received September 7, 2016.
  • Accepted October 5, 2016.
  • ©2016 American Association for Cancer Research.
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Cancer Epidemiology Biomarkers & Prevention: 26 (3)
March 2017
Volume 26, Issue 3
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Alcohol Consumption and the Risk of Colorectal Cancer for Mismatch Repair Gene Mutation Carriers
S. Ghazaleh Dashti, Daniel D. Buchanan, Harindra Jayasekara, Driss Ait Ouakrim, Mark Clendenning, Christophe Rosty, Ingrid M. Winship, Finlay A. Macrae, Graham G. Giles, Susan Parry, Graham Casey, Robert W. Haile, Steven Gallinger, Loïc Le Marchand, Stephen N. Thibodeau, Noralane M. Lindor, Polly A. Newcomb, John D. Potter, John A. Baron, John L. Hopper, Mark A. Jenkins and Aung Ko Win
Cancer Epidemiol Biomarkers Prev March 1 2017 (26) (3) 366-375; DOI: 10.1158/1055-9965.EPI-16-0496

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Alcohol Consumption and the Risk of Colorectal Cancer for Mismatch Repair Gene Mutation Carriers
S. Ghazaleh Dashti, Daniel D. Buchanan, Harindra Jayasekara, Driss Ait Ouakrim, Mark Clendenning, Christophe Rosty, Ingrid M. Winship, Finlay A. Macrae, Graham G. Giles, Susan Parry, Graham Casey, Robert W. Haile, Steven Gallinger, Loïc Le Marchand, Stephen N. Thibodeau, Noralane M. Lindor, Polly A. Newcomb, John D. Potter, John A. Baron, John L. Hopper, Mark A. Jenkins and Aung Ko Win
Cancer Epidemiol Biomarkers Prev March 1 2017 (26) (3) 366-375; DOI: 10.1158/1055-9965.EPI-16-0496
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