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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Epidemiology, Lifestyle, and Genetics

Abstract A77: Walking and vigorous exercise and risk of breast cancer in African American women

zhihong Gong, Chi-Chen Hong, Elisa Bandera, Lucile Adams-Campbell, Song-Yi Park, Gary Zirpoli, Andrew Olshan, Christine Ambrosone, Julie Palmer and Lynn Rosenberg
zhihong Gong
1Roswell Park Cancer Institute, Buffalo, NY,
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Chi-Chen Hong
1Roswell Park Cancer Institute, Buffalo, NY,
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Elisa Bandera
2Rutgers Cancer Institute of New Jersey, New Brunswick, NJ,
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Lucile Adams-Campbell
3Georgetown Lombardi Comprehensive Cancer Center, Washington, DC,
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Song-Yi Park
4University of Hawaii Cancer Center, Honolulu,HI,
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Gary Zirpoli
1Roswell Park Cancer Institute, Buffalo, NY,
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Andrew Olshan
5University of North Carolina, Chapel Hill, NC,
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Christine Ambrosone
1Roswell Park Cancer Institute, Buffalo, NY,
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Julie Palmer
6Slone Epidemiology Center at Boston University, Boston, MA.
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Lynn Rosenberg
6Slone Epidemiology Center at Boston University, Boston, MA.
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DOI: 10.1158/1538-7755.DISP15-A77 Published March 2016
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Abstracts: Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; November 13-16, 2015; Atlanta, Georgia

Abstract

The relationship between physical activity and breast cancer risk has been extensively studied among women of European descent, with most studies reporting an inverse association. However, data on African American (AA) women and by tumor subtypes are sparse. Thus, we examined associations of vigorous exercise and walking for exercise and breast cancer risk overall and by estrogen receptor (ER) status in the African American Breast Cancer Epidemiology and Risk (AMBER) Consortium. We pooled data on AA women from four large studies, the Black Women's Health Study, Carolina Breast Cancer Study, Multiethnic Cohort Study and Women's Circle of Health Study, for 2,482 ER+ cases, 1,374 ER- cases and 16,959 controls. Multivariable logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) for the risk of overall breast cancer, and polytomous logistic regression was used to model the risk of ER+ and ER- cancer. Based on all four studies, for recent vigorous exercise (reported by 29% of controls), the OR was 0.88 (95% CI: 0.81-0.96) for breast cancer overall, 0.88 (95% CI: 0.80-0.98) for ER+ breast cancer and 0.93 (95% CI: 0.82-1.06) for ER- breast cancer. There was a statistically significant trend across hours per week of vigorous activity for breast cancer overall (p for trend=0.006) and for ER+ cancer (p for trend=0.02), but there was not a clear dose response relationship, with the strongest reduced risk in the 1-2 and 3-4 hours/week categories. Data on walking for exercise, as the most frequently reported activity among adults who meet guidelines for regular physical activity (53% in controls), was available from two studies. Any walking for exercise was associated with reduced risk of breast cancer overall (OR=0.88, 95% CI: 0.80-0.97) and ER+ cancer (OR=0.87, 95% CI: 0.77-0.98), but not ER- cancer (OR=0.95, 95 CI: 0.81-1.12). There was a significant trend across hours per week of walking for breast cancer overall (p for trend=0.008) and ER+ breast cancer (p for trend=0.02), with the strongest reduced risk in the 5+ hours/week category. Our results from this large pooling study of AA women provide evidence that vigorous exercise and walking for exercise are associated with reduced risk of breast cancer, specifically ER+ cancer.

Citation Format: zhihong Gong, Chi-Chen Hong, Elisa Bandera, Lucile Adams-Campbell, Song-Yi Park, Gary Zirpoli, Andrew Olshan, Christine Ambrosone, Julie Palmer, Lynn Rosenberg. Walking and vigorous exercise and risk of breast cancer in African American women. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr A77.

  • ©2016 American Association for Cancer Research.
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Cancer Epidemiology Biomarkers & Prevention: 25 (3 Supplement)
March 2016
Volume 25, Issue 3 Supplement
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Abstract A77: Walking and vigorous exercise and risk of breast cancer in African American women
zhihong Gong, Chi-Chen Hong, Elisa Bandera, Lucile Adams-Campbell, Song-Yi Park, Gary Zirpoli, Andrew Olshan, Christine Ambrosone, Julie Palmer and Lynn Rosenberg
Cancer Epidemiol Biomarkers Prev March 1 2016 (25) (3 Supplement) A77; DOI: 10.1158/1538-7755.DISP15-A77

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Abstract A77: Walking and vigorous exercise and risk of breast cancer in African American women
zhihong Gong, Chi-Chen Hong, Elisa Bandera, Lucile Adams-Campbell, Song-Yi Park, Gary Zirpoli, Andrew Olshan, Christine Ambrosone, Julie Palmer and Lynn Rosenberg
Cancer Epidemiol Biomarkers Prev March 1 2016 (25) (3 Supplement) A77; DOI: 10.1158/1538-7755.DISP15-A77
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