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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Family History of Cancer in Relation to Breast Cancer Subtypes in African American Women

Traci N. Bethea, Lynn Rosenberg, Nelsy Castro-Webb, Kathryn L. Lunetta, Lara E. Sucheston-Campbell, Edward A. Ruiz-Narváez, Marjory Charlot, Song-Yi Park, Elisa V. Bandera, Melissa A. Troester, Christine B. Ambrosone and Julie R. Palmer
Traci N. Bethea
1Slone Epidemiology Center at Boston University, Boston, Massachusetts.
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  • For correspondence: tnb@bu.edu
Lynn Rosenberg
1Slone Epidemiology Center at Boston University, Boston, Massachusetts.
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Nelsy Castro-Webb
1Slone Epidemiology Center at Boston University, Boston, Massachusetts.
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Kathryn L. Lunetta
2Boston University School of Public Health, Boston, Massachusetts.
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Lara E. Sucheston-Campbell
3Roswell Park Cancer Institute, Buffalo, New York.
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Edward A. Ruiz-Narváez
1Slone Epidemiology Center at Boston University, Boston, Massachusetts.
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Marjory Charlot
4Boston University School of Medicine, Boston, Massachusetts.
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Song-Yi Park
5University of Hawaii Cancer Center, Honolulu, Hawaii.
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Elisa V. Bandera
6Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
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Melissa A. Troester
7University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina.
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Christine B. Ambrosone
3Roswell Park Cancer Institute, Buffalo, New York.
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Julie R. Palmer
1Slone Epidemiology Center at Boston University, Boston, Massachusetts.
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DOI: 10.1158/1055-9965.EPI-15-1068 Published February 2016
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Abstract

Background: The evidence on the relation of family history of cancers other than breast cancer to breast cancer risk is conflicting, and most studies have not assessed specific breast cancer subtypes.

Methods: We assessed the relation of first-degree family history of breast, prostate, lung, colorectal, ovarian, and cervical cancer and lymphoma or leukemia, to the risk of estrogen receptor–positive (ER+), ER−, and triple-negative breast cancer in data from the African American Breast Cancer Epidemiology and Risk Consortium. Multivariable logistic regression models were used to calculate ORs and 95% confidence intervals (CI).

Results: There were 3,023 ER+ and 1,497 ER− breast cancer cases (including 696 triple-negative cases) and 17,420 controls. First-degree family history of breast cancer was associated with increased risk of each subtype: OR = 1.76 (95% CI, 1.57–1.97) for ER+, 1.67 (1.42–1.95) for ER−, and 1.72 (1.38–2.13) for triple-negative breast cancer. Family history of cervical cancer was associated with increased risk of ER− (OR = 2.39; 95% CI, 1.36–4.20), but not ER+ cancer. Family history of both breast and prostate cancer was associated with increased risk of ER+ (3.40; 2.42–4.79) and ER− (2.09; 1.21–3.63) cancer, but family history of both breast and lung cancer was associated only with ER− cancer (2.11; 1.29–3.46).

Conclusions: A family history of cancers other than breast may influence the risk of breast cancer, and associations may differ by subtype.

Impact: Greater surveillance and counseling for additional screening may be warranted for women with a family history of cancer. Cancer Epidemiol Biomarkers Prev; 25(2); 366–73. ©2015 AACR.

  • Received October 13, 2015.
  • Revision received December 7, 2015.
  • Accepted December 10, 2015.
  • ©2015 American Association for Cancer Research.
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Cancer Epidemiology Biomarkers & Prevention: 25 (2)
February 2016
Volume 25, Issue 2
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Family History of Cancer in Relation to Breast Cancer Subtypes in African American Women
Traci N. Bethea, Lynn Rosenberg, Nelsy Castro-Webb, Kathryn L. Lunetta, Lara E. Sucheston-Campbell, Edward A. Ruiz-Narváez, Marjory Charlot, Song-Yi Park, Elisa V. Bandera, Melissa A. Troester, Christine B. Ambrosone and Julie R. Palmer
Cancer Epidemiol Biomarkers Prev February 1 2016 (25) (2) 366-373; DOI: 10.1158/1055-9965.EPI-15-1068

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Family History of Cancer in Relation to Breast Cancer Subtypes in African American Women
Traci N. Bethea, Lynn Rosenberg, Nelsy Castro-Webb, Kathryn L. Lunetta, Lara E. Sucheston-Campbell, Edward A. Ruiz-Narváez, Marjory Charlot, Song-Yi Park, Elisa V. Bandera, Melissa A. Troester, Christine B. Ambrosone and Julie R. Palmer
Cancer Epidemiol Biomarkers Prev February 1 2016 (25) (2) 366-373; DOI: 10.1158/1055-9965.EPI-15-1068
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