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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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The Breast–Thyroid Cancer Link: A Systematic Review and Meta-analysis

Sarah M. Nielsen, Michael G. White, Susan Hong, Briseis Aschebrook-Kilfoy, Edwin L. Kaplan, Peter Angelos, Swati A. Kulkarni, Olufunmilayo I. Olopade and Raymon H. Grogan
Sarah M. Nielsen
1Department of Medicine, Center for Clinical Cancer Genetics and Global Health, The University of Chicago, Chicago, Illinois.
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Michael G. White
2Endocrine Surgery Research Program, Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois.
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Susan Hong
3Breast Cancer Survivorship Program, Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, Illinois.
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Briseis Aschebrook-Kilfoy
4Department of Public Health Sciences, The University of Chicago, Chicago Illinois.
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Edwin L. Kaplan
2Endocrine Surgery Research Program, Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois.
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Peter Angelos
2Endocrine Surgery Research Program, Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois.
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Swati A. Kulkarni
5Department of Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
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Olufunmilayo I. Olopade
1Department of Medicine, Center for Clinical Cancer Genetics and Global Health, The University of Chicago, Chicago, Illinois.
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Raymon H. Grogan
2Endocrine Surgery Research Program, Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois.
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  • For correspondence: rgrogan@surgery.bsd.uchicago.edu
DOI: 10.1158/1055-9965.EPI-15-0833 Published February 2016
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Abstract

Rates of thyroid cancer in women with a history of breast cancer are higher than expected. Similarly, rates of breast cancer in those with a history of thyroid cancer are increased. Explanations for these associations include detection bias, shared hormonal risk factors, treatment effect, and genetic susceptibility. With increasing numbers of breast and thyroid cancer survivors, clinicians should be particularly cognizant of this association. Here, we perform a systematic review and meta-analysis of the literature utilizing PubMed and Scopus search engines to identify all publications studying the incidence of breast cancer as a secondary malignancy following a diagnosis of thyroid cancer or thyroid cancer following a diagnosis of breast cancer. This demonstrated an increased risk of thyroid cancer as a secondary malignancy following breast cancer [OR = 1.55; 95% confidence interval (CI), 1.44–1.67] and an increased risk of breast cancer as a secondary malignancy following thyroid cancer (OR = 1.18; 95% CI, 1.09–1.26). There is a clear increase in the odds of developing either thyroid or breast cancer as a secondary malignancy after diagnosis with the other. Here, we review this association and current hypothesis as to the cause of this correlation. Cancer Epidemiol Biomarkers Prev; 25(2); 231–8. ©2016 AACR.

  • Received August 4, 2015.
  • Revision received October 20, 2015.
  • Accepted October 29, 2015.
  • ©2016 American Association for Cancer Research.
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Cancer Epidemiology Biomarkers & Prevention: 25 (2)
February 2016
Volume 25, Issue 2
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The Breast–Thyroid Cancer Link: A Systematic Review and Meta-analysis
Sarah M. Nielsen, Michael G. White, Susan Hong, Briseis Aschebrook-Kilfoy, Edwin L. Kaplan, Peter Angelos, Swati A. Kulkarni, Olufunmilayo I. Olopade and Raymon H. Grogan
Cancer Epidemiol Biomarkers Prev February 1 2016 (25) (2) 231-238; DOI: 10.1158/1055-9965.EPI-15-0833

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The Breast–Thyroid Cancer Link: A Systematic Review and Meta-analysis
Sarah M. Nielsen, Michael G. White, Susan Hong, Briseis Aschebrook-Kilfoy, Edwin L. Kaplan, Peter Angelos, Swati A. Kulkarni, Olufunmilayo I. Olopade and Raymon H. Grogan
Cancer Epidemiol Biomarkers Prev February 1 2016 (25) (2) 231-238; DOI: 10.1158/1055-9965.EPI-15-0833
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    • Introduction
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    • External Beam Radiation to the Breast and the Risk of Thyroid Cancer
    • Radioactive Iodine for Thyroid Cancer and the Risk of Breast Cancer
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