Article Figures & Data
Figures
- Figure 1.
Casewise concordance of breast cancer risk by age at diagnosis for MZ pairs and DZ pairs, and the marginal risk of breast cancer. The risks are adjusted for censoring and competing risk of death. Transparent areas show 95% confidence interval.
- Figure 2.
Additive genetic and common environment component of liability to breast cancer by age at diagnosis. Bias correction due to censoring and competing risk of death by the inverse probability weighting technique. Transparent areas show 95% confidence interval.
- Figure 3.
Pattern of cumulative breast cancer hazard in monozygotic (left) and dizygotic (right) twins with respect to age of diagnosis of the co-twin. Bias correcting due to censoring and competing risk.
Tables
- Table 1.
Description of female twins from same-sexed pairs in the Nordic Twin Studies of Cancer (NorTwinCan) cohorts
Denmark Finland Norway Sweden Total Birth cohorts 1870–2004 1880–1957 1895–1979 1886–2008 Cancer registration since 1943 1953 1953 1958 Initiation of follow-up 1943 1975 1964 1961 End of follow-up 2009–12-31 2010–12-31 2008–12-31 2009–12-31 N female twins 33,339 12,507 12,824 45,869 104,539 N MZ/DZ complete pairs 6,235/10,430 2,026/4,179 2,935/3,439 9,859/12,892 21,055/30,940 N MZ/DZ complete uncensored pairs 1,251/2,332 403/792 195/232 1,781/3,238 3,630/6,594 N breast cancer cases 1,229 635 358 1,711 3,933 N breast cancer in complete pairs 1,229 630 352 1,700 3,911 N breast cancer in complete uncensored pairs 695 221 91 907 1,914 N concordant uncensored MZ/DZ pairs 44/48 15/23 13/5 52/65 124/141 N discordant uncensored MZ/DZ pairs 170/341 39/106 18/37 243/430 470/914 N unaffected uncensored MZ/DZ pairs 1,037/1,943 349/663 164/190 1,486/2,743 3,036/5,539 - Table 2.
Cumulative risk, casewise concordance risk, and heritability of liability to breast cancer diagnosis in the NorTwinCan database; bias correction due to censoring by the inverse probability weighting technique; lifetime risk for premenopausal cancer is up to 50 years, although lifetime risk for postmenopausal cancer is conditional on survival to age 53 years
Casewise concordance and 95% CI Estimates and 95% CIs from twin modeling Age at diagnosis Lifetime risk and 95% CI MZ DZ Common env. c2 Heritability h2 Any ages 8.1% (7.8%–8.5%) 28% (23%–33%) 20% (17%–24%) 16% (10%–32%) 31% (10%–52%) <50 years 1.5% (1.2%–1.7%) 10% (5%–17%) 6% (3%–10%) 12% (0%–39%) 27% (0%–62%) ≥53 years 7.2% (6.6%–7.8%) 21% (16%–27%) 16% (13%–20%) 16% (0%–34%) 22% (0%–46%) - Table 3.
Relative recurrence risk and multilocus index of breast cancer by decades of age of diagnosis of breast cancer for female MZ and DZ pairs; bias correction due to censoring and competing risk of death
Age Relative recurrence risk for MZ Relative recurrence risk for DZ Multilocus index (95% CI) (95% CI) (95% CI) All 2.16 (1.77–2.55) 1.70 (1.41–1.99) 1.64 (0.78–2.50) −50 5.91 (1.75–10.07) 3.51 (1.02–6.00) 1.96 (−0.59–4.51) 50–60 4.93 (3.36–6.50) 2.77 (1.83–3.71) 2.21 (0.74–3.68) 60–70 2.98 (2.27–3.69) 2.24 (1.73–2.75) 1.60 (0.74–2.46) 70–80 2.50 (2.01–2.99) 1.80 (1.45–2.15) 1.87 (0.87–2.87) 80–90 2.15 (1.76–2.54) 1.67 (1.38–1.96) 1.71 (0.77–2.65) 90+ 2.04 (1.65–2.43) 1.68 (1.39–1.97) 1.53 (0.65–2.41)
Volume 25, Issue 1
