Lifetime Physical Activity and the Risk of Non-Hodgkin Lymphoma

Terry Boyle; Richard P. Gallagher; Randy D. Gascoyne; Joseph M. Connors; Nhu D. Le; John J. Spinelli

doi:10.1158/1055-9965.EPI-14-1303

DOI: 10.1158/1055-9965.EPI-14-1303 Published May 2015

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Additional Files

Table 1.

Characteristics of the participants in a case–control study of NHL, British Columbia, Canada, 2000–2004

	Controls (n = 818)	Cases (n = 749)
Characteristic	n (%)	n (%)
Sex
Male	435 (53.2)	441 (58.9)
Female	383 (46.8)	308 (41.1)
Age, y
20–39	114 (13.9)	64 (8.5)
40–49	117 (14.3)	86 (11.5)
50–59	172 (21.0)	182 (24.3)
60–69	211 (25.8)	198 (26.4)
70+	204 (24.9)	219 (29.2)
Residential location
Greater Vancouver Regional District	634 (77.5)	615 (82.1)
Capital Region District	184 (22.5)	134 (17.9)
Ethnicity
White	645 (78.9)	612 (81.7)
Asian	93 (11.4)	75 (10.0)
South Asian	43 (5.3)	27 (3.6)
Other/mixed	37 (4.5)	35 (4.7)
Education
Did not complete high school	111 (13.7)	140 (18.8)
High school only	191 (23.6)	189 (25.4)
Vocational qualification	188 (23.2)	145 (19.5)
Some university	74 (9.1)	58 (7.8)
Undergraduate university degree	154 (19.0)	126 (16.9)
Postgraduate university degree	91 (11.2)	87 (11.7)
Autoimmune disorder
No	707 (86.7)	612 (81.8)
Yes	109 (13.4)	136 (18.2)

Table 2.

Associations between lifetime total, moderate-intensity, and vigorous-intensity physical activity and the risk of NHL in a case–control study conducted in British Columbia, Canada, 2000–2004

	Controls (n = 818)	Cases (n = 749)	All participants	Males	Females
Lifetime physical activity	n (%)	n (%)	AOR^a (95% CI)	AOR^a (95% CI)	AOR^a (95% CI)
Total
0–35.9 MET-hours/week	205 (25.1)	208 (27.7)	1.00	1.00	1.00
36–58.9 MET-hours/week	208 (25.4)	165 (22.0)	0.79 (0.59–1.06)	0.87 (0.60–1.26)	0.66 (0.41–1.05)
59–84.9 MET-hours/week	208 (25.4)	154 (20.6)	0.73 (0.54–0.99)	0.75 (0.50–1.11)	0.64 (0.40–1.03)
85+ MET-hours/week	197 (24.1)	222 (29.6)	1.16 (0.87–1.55)	1.14 (0.78–1.68)	1.07 (0.68–1.68)
P_Trend			0.332	0.661	0.591
Moderate intensity
0–18.9 MET-hours/week	209 (25.6)	205 (27.4)	1.00	1.00	1.00
19–35.9 MET-hours/week	201 (24.6)	172 (23.0)	0.86 (0.64–1.15)	0.79 (0.55–1.12)	1.02 (0.60–1.75)
36–55.9 MET-hours/week	202 (24.7)	163 (21.8)	0.86 (0.63–1.17)	0.90 (0.61–1.34)	0.77 (0.46–1.27)
56+ MET-hours/week	206 (25.2)	209 (27.9)	1.15 (0.84–1.57)	1.06 (0.68–1.65)	1.14 (0.71–1.83)
P_Trend			0.375	0.807	0.062
Vigorous intensity
0–4.9 MET-hours/week	199 (24.3)	220 (29.4)	1.00	1.00	1.00
5–18.9 MET-hours/week	212 (25.9)	177 (23.6)	0.69 (0.52–0.93)	0.58 (0.38–0.89)	0.79 (0.52–1.18)
19–36.4 MET-hours/week	204 (24.9)	165 (22.0)	0.68 (0.50–0.92)	0.51 (0.33–0.78)	0.99 (0.64–1.53)
36.5+ MET-hours/week	203 (24.8)	187 (25.0)	0.75 (0.55–1.01)	0.71 (0.47–1.09)	0.62 (0.38–1.01)
P_Trend			0.072	0.228	0.144

Abbreviation: AOR, adjusted odds ratio.

↵^aAdjusted for the frequency matching variables (age group, sex, and residential location) and ethnicity. Moderate-intensity and vigorous-intensity physical activity are mutually adjusted.

Table 3.

Associations between lifetime total, moderate-intensity, and vigorous-intensity physical activity and the risk of NHL subtypes in a case–control study conducted in British Columbia, Canada, 2000–2004

	Diffuse large B-cell (n = 202)	Follicular (n = 188)	Other B-cell (n = 268)	T-cell (n = 70)
Lifetime physical activity	AOR^a (95% CI)	AOR^a (95% CI)	AOR^a (95% CI)	AOR^a (95% CI)
Total
0–35.9 MET-hours/week	1.00	1.00	1.00	1.00
36–58.9 MET-hours/week	0.70 (0.44–1.11)	0.93 (0.59–1.49)	0.87 (0.58–1.30)	0.65 (0.31–1.35)
59–84.9 MET-hours/week	0.80 (0.51–1.28)	0.73 (0.44–1.19)	0.81 (0.54–1.23)	0.58 (0.27–1.24)
85+ MET-hours/week	1.22 (0.79–1.88)	1.26 (0.80–1.99)	1.04 (0.69–1.57)	1.19 (0.61–2.32)
P_Trend	0.256	0.450	0.883	0.648
Moderate intensity
0–18.9 MET-hours/week	1.00	1.00	1.00	1.00
19–35.9 MET-hours/week	0.70 (0.44–1.11)	0.89 (0.55–1.44)	1.12 (0.75–1.69)	0.72 (0.36–1.43)
36–55.9 MET-hours/week	0.97 (0.62–1.53)	0.96 (0.59–1.55)	0.82 (0.53–1.29)	0.54 (0.24–1.20)
56+ MET-hours/week	1.00 (0.62–1.61)	1.08 (0.66–1.77)	1.48 (0.96–2.28)	0.91 (0.44–1.86)
P_Trend	0.704	0.697	0.178	0.635
Vigorous intensity
0–4.9 MET-hours/week	1.00	1.00	1.00	1.00
5–18.9 MET-hours/week	0.58 (0.36–0.93)	0.59 (0.37–0.93)	0.78 (0.52–1.15)	0.88 (0.45–1.72)
19–36.4 MET-hours/week	0.72 (0.45–1.15)	0.64 (0.40–1.02)	0.77 (0.51–1.16)	0.48 (0.22–1.06)
36.5+ MET-hours/week	0.94 (0.60–1.49)	0.71 (0.44–1.14)	0.59 (0.38–0.92)	0.80 (0.39–1.67)
P_Trend	0.859	0.207	0.028	0.323

Abbreviation: AOR, adjusted odds ratio.

↵^aAdjusted for the frequency matching variables (age group, sex, and residential location) and ethnicity. Moderate-intensity and vigorous-intensity physical activity are mutually adjusted.

Additional Files

Tables

Supplementary Data

Supplementary Table 1 - Distribution of lifetime total, moderate-intensity and vigorous-intensity physical activity by sex and non-Hodgkin lymphoma subtype in a case-control study conducted in British Columbia, Canada, 2000-2004.
Supplementary Table 2 - Distribution of total, moderate-intensity and vigorous-intensity physical activity performed in specific age-periods by cases and controls in a case-control study conducted in British Columbia, Canada, 2000-2004.
Supplementary Table 3 - Associations between total, moderate-intensity and vigorous-intensity physical activity performed in specific age-periods and the risk of non-Hodgkin lymphoma in a case-control study conducted in British Columbia, Canada, 2000-2004.
Supplementary Figure 1 - Physical activity questionnaire used in a case-control study of non-Hodgkin lymphoma conducted in British Columbia, Canada, 2000-2004.
Supplementary Figure 2 - Directed acyclic graph used to select covariates in the analysis of the association between physical activity and the risk of non-Hodgkin lymphoma in a case-control study conducted in British Columbia, Canada, 2000-2004.