Article Figures & Data
Figures
- Figure 1.
Association between genetic variants and Epstein–Barr virus (EBV)-positive Hodgkin lymphoma within an approximately 6.5 Mb region of the extended MHC located at 6p21. Overlayed plots of the −log10 (P values) for 25,961 SNPs by their chromosomal position. Results of the EBV-positive cHL analysis unadjusted for previously associated SNPs in the region are plotted in gray. Plotted in black are the results for EBV-positive cHL adjusted by other associated genetic loci, including rs2734986, rs6904029, rs2248462, rs2395185, and rs6903608. The horizontal dotted line represents the genome-wide significance threshold level (P < 1 × 10−7). The arrow highlights the new EBV-positive associated variant rs6457715. There are three SNPs (rs6457715, rs6457714, and rs6457711) exceeding the P value of threshold at the 33 Mb position, although results of two (rs6457715 and rs6457714) appear overlapping.
- Figure 2.
Summary of results for rs6457715 and risk of HL by cHL subgroups. Results of analyses combining the GWAS and replication stages are shown for total cHL and by histology, tumor cell EBV status, age of onset, and study. EBV-positive cHL results are also shown stratified by study. ORs and 95% CIs were derived using multiple logistic regression assuming a log-additive genetic model and adjusting for the five known MHC loci (i.e., rs2734986, rs2248462, rs2395185, rs6903608, and rs3823355), sex and eight principal components analysis eigenvectors (or country in the replication analysis). The risk allele is the major allele (A) of rs6457715. Combined GWAS and replication results were generated using inverse variance weighting meta-analysis. aStudy-specific results for EPILYMPH and UK studies included GWAS and replication data, whereas results for SCALE and the Netherlands studies are those from the GWAS.
Additional Files
Supplementary Data
- Supplementary Tables S1- S6 and Supplementary Figure S1 - Supplementary Table S1. Summary of results for rs6457715 in total classical Hodgkin lymphoma and subgroups. Supplementary Table S2. Regression analysis of EBV-positive cHL risk and rs6457715 genotype. Supplementary Table S3. Association between risk score comprising rs2734986, rs6904029, and rs6457715 and EBV+ Hodgkin lymphoma in the GWAS population. Supplementary Table S4. HLA-DPB1 significant eQTLs and their effect on EBV-positive cHL risk. Supplementary Table S5. Subjects included in the genome-wide association imputation analysis and independent replication of classical Hodgkin lymphoma. Supplementary Table S6. Concordance rates between HLA imputed and directly genotyped data across 334 UK and 284 Dutch individuals. Supplementary Figure S1. Association between genetic variants and HL and Epstein-Barr virus (EBV)-negative HL within an approximately 6.5 Mb region of the extended major histocompatibility complex located at 6p21.
Volume 24, Issue 12
