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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention

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Research Articles

Gene–Environment Interaction Involving Recently Identified Colorectal Cancer Susceptibility Loci

Elizabeth D. Kantor, Carolyn M. Hutter, Jessica Minnier, Sonja I. Berndt, Hermann Brenner, Bette J. Caan, Peter T. Campbell, Christopher S. Carlson, Graham Casey, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Michelle Cotterchio, Mengmeng Du, David Duggan, Charles S. Fuchs, Edward L. Giovannucci, Jian Gong, Tabitha A. Harrison, Richard B. Hayes, Brian E. Henderson, Michael Hoffmeister, John L. Hopper, Mark A. Jenkins, Shuo Jiao, Laurence N. Kolonel, Loic Le Marchand, Mathieu Lemire, Jing Ma, Polly A. Newcomb, Heather M. Ochs-Balcom, Bethann M. Pflugeisen, John D. Potter, Anja Rudolph, Robert E. Schoen, Daniela Seminara, Martha L. Slattery, Deanna L. Stelling, Fridtjof Thomas, Mark Thornquist, Cornelia M. Ulrich, Greg S. Warnick, Brent W. Zanke, Ulrike Peters, Li Hsu and Emily White
Elizabeth D. Kantor
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
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  • For correspondence: ekantor@hsph.harvard.edu
Carolyn M. Hutter
Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, Maryland.
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Jessica Minnier
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, Oregon.
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Sonja I. Berndt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
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Hermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.German Cancer Consortium (DKTK), Heidelberg, Germany.
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Bette J. Caan
Division of Research, Kaiser Permanente Medical Care Program, Oakland, California.
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Peter T. Campbell
Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
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Christopher S. Carlson
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
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Graham Casey
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
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Andrew T. Chan
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
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Jenny Chang-Claude
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
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Stephen J. Chanock
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
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Michelle Cotterchio
Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada.
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Mengmeng Du
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
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David Duggan
Translational Genomics Research Institute, Phoenix, Arizona.
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Charles S. Fuchs
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.
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Edward L. Giovannucci
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts.
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Jian Gong
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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Tabitha A. Harrison
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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Richard B. Hayes
Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York.
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Brian E. Henderson
Keck School of Medicine, University of Southern California, Los Angeles, California.
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Michael Hoffmeister
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
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John L. Hopper
Melbourne School of Population Health, The University of Melbourne, VIC, Australia.
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Mark A. Jenkins
Melbourne School of Population Health, The University of Melbourne, VIC, Australia.
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Shuo Jiao
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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Laurence N. Kolonel
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
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Loic Le Marchand
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
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Mathieu Lemire
Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
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Jing Ma
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
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Polly A. Newcomb
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
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Heather M. Ochs-Balcom
Department of Social and Preventive Medicine, University at Buffalo, Buffalo, New York.
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Bethann M. Pflugeisen
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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John D. Potter
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.Centre for Public Health Research, Massey University, Wellington, New Zealand.
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Anja Rudolph
Division of Cancer Epidemiology, Unit of Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.
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Robert E. Schoen
Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
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Daniela Seminara
Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, Maryland.
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Martha L. Slattery
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah.
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Deanna L. Stelling
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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Fridtjof Thomas
Department of Preventive Medicine, University of Tennessee Health Science Center, University of Tennessee, Memphis, Tennessee.
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Mark Thornquist
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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Cornelia M. Ulrich
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany.
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Greg S. Warnick
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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Brent W. Zanke
Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
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Ulrike Peters
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
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Li Hsu
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington.
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Emily White
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
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DOI: 10.1158/1055-9965.EPI-14-0062 Published September 2014
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Abstract

Background: Genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) that are associated with risk of colorectal cancer. Prior research has evaluated the presence of gene–environment interaction involving the first 10 identified susceptibility loci, but little work has been conducted on interaction involving SNPs at recently identified susceptibility loci, including: rs10911251, rs6691170, rs6687758, rs11903757, rs10936599, rs647161, rs1321311, rs719725, rs1665650, rs3824999, rs7136702, rs11169552, rs59336, rs3217810, rs4925386, and rs2423279.

Methods: Data on 9,160 cases and 9,280 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) and Colon Cancer Family Registry (CCFR) were used to evaluate the presence of interaction involving the above-listed SNPs and sex, body mass index (BMI), alcohol consumption, smoking, aspirin use, postmenopausal hormone (PMH) use, as well as intake of dietary calcium, dietary fiber, dietary folate, red meat, processed meat, fruit, and vegetables. Interaction was evaluated using a fixed effects meta-analysis of an efficient Empirical Bayes estimator, and permutation was used to account for multiple comparisons.

Results: None of the permutation-adjusted P values reached statistical significance.

Conclusions: The associations between recently identified genetic susceptibility loci and colorectal cancer are not strongly modified by sex, BMI, alcohol, smoking, aspirin, PMH use, and various dietary factors.

Impact: Results suggest no evidence of strong gene–environment interactions involving the recently identified 16 susceptibility loci for colorectal cancer taken one at a time. Cancer Epidemiol Biomarkers Prev; 23(9); 1824–33. ©2014 AACR.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Epidemiology, Biomarkers & Prevention Online (http://cebp.aacrjournals.org/).

  • Received January 20, 2014.
  • Revision received May 2, 2014.
  • Accepted June 2, 2014.
  • ©2014 American Association for Cancer Research.
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Cancer Epidemiology Biomarkers & Prevention: 23 (9)
September 2014
Volume 23, Issue 9
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Gene–Environment Interaction Involving Recently Identified Colorectal Cancer Susceptibility Loci
Elizabeth D. Kantor, Carolyn M. Hutter, Jessica Minnier, Sonja I. Berndt, Hermann Brenner, Bette J. Caan, Peter T. Campbell, Christopher S. Carlson, Graham Casey, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Michelle Cotterchio, Mengmeng Du, David Duggan, Charles S. Fuchs, Edward L. Giovannucci, Jian Gong, Tabitha A. Harrison, Richard B. Hayes, Brian E. Henderson, Michael Hoffmeister, John L. Hopper, Mark A. Jenkins, Shuo Jiao, Laurence N. Kolonel, Loic Le Marchand, Mathieu Lemire, Jing Ma, Polly A. Newcomb, Heather M. Ochs-Balcom, Bethann M. Pflugeisen, John D. Potter, Anja Rudolph, Robert E. Schoen, Daniela Seminara, Martha L. Slattery, Deanna L. Stelling, Fridtjof Thomas, Mark Thornquist, Cornelia M. Ulrich, Greg S. Warnick, Brent W. Zanke, Ulrike Peters, Li Hsu and Emily White
Cancer Epidemiol Biomarkers Prev September 1 2014 (23) (9) 1824-1833; DOI: 10.1158/1055-9965.EPI-14-0062

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Gene–Environment Interaction Involving Recently Identified Colorectal Cancer Susceptibility Loci
Elizabeth D. Kantor, Carolyn M. Hutter, Jessica Minnier, Sonja I. Berndt, Hermann Brenner, Bette J. Caan, Peter T. Campbell, Christopher S. Carlson, Graham Casey, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Michelle Cotterchio, Mengmeng Du, David Duggan, Charles S. Fuchs, Edward L. Giovannucci, Jian Gong, Tabitha A. Harrison, Richard B. Hayes, Brian E. Henderson, Michael Hoffmeister, John L. Hopper, Mark A. Jenkins, Shuo Jiao, Laurence N. Kolonel, Loic Le Marchand, Mathieu Lemire, Jing Ma, Polly A. Newcomb, Heather M. Ochs-Balcom, Bethann M. Pflugeisen, John D. Potter, Anja Rudolph, Robert E. Schoen, Daniela Seminara, Martha L. Slattery, Deanna L. Stelling, Fridtjof Thomas, Mark Thornquist, Cornelia M. Ulrich, Greg S. Warnick, Brent W. Zanke, Ulrike Peters, Li Hsu and Emily White
Cancer Epidemiol Biomarkers Prev September 1 2014 (23) (9) 1824-1833; DOI: 10.1158/1055-9965.EPI-14-0062
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