Article Figures & Data
Figures
- Figure 1.
The ROC curve for EBNA1 IgA marker (Δ = 1.04). The optimized threshold value was defined as the value on the ROC curve with the highest specificity that successfully identified at least 80% of incident NPC cases (80% sensitivity) in this high-risk population. The alternative threshold had the highest specificity while identifying at least 90% of incident NPC.
Tables
- Table 1.
Sensitivity and specificity for anti-EBV IgA antibodies, applied to prevalent NPC and healthy controls from Taiwan
IgA Marker Sensitivity for prevalent NPCa Specificity in healthy, community controls Viral capsid antigen (VCAp18) 78.9 49.3 Early prevalent disease 76.1 Late prevalent disease 81.3 Epstein–Barr nuclear antigen (EBNA1) 92.3 80.0 Early prevalent disease 95.5 Late prevalent disease 89.3 Early antigen (Ead_p47) 43.0 81.3 Early prevalent disease 38.8 Late prevalent disease 46.7 Early antigen (EAp138) 47.9 82.7 Early prevalent disease 38.8 Late prevalent disease 56.0 Combined VCAp18 + EBNA1 ELISA 99.3 32.0 Early prevalent disease 100 Late prevalent disease 98.7 NOTE: Early disease, WHO stage I/II; late disease, WHO stage III/IV.
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↵aThe percentages are based on a threshold value for determining a positive result of ≥1.0.
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- Table 2.
Sensitivity and specificity for anti-EBV IgA antibodies, applied to high-risk multiplex family members from Taiwan
IgA marker Sensitivity for incident NPCa Specificity in high-risk controls Viral capsid antigen (VCAp18) 52.4 46.4 Epstein–Barr nuclear antigen (EBNA1) 66.7 85.7 Early antigen (Ead_p47) 0.0 92.9 Early antigen (EAp138) 0.0 95.2 Combined VCAp18 + EBNA1 ELISA 85.7 35.7 -
↵aThe percentages are based on a threshold value for determining a positive result of ≥1.0.
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- Table 3.
Application of EBNA1 IgA as screening tool for incident NPC in high-risk multiplex Taiwanese family members (40+ years of age)
Screened population 5-year NPC risk Sensitivity Specificity No. of screened/NPC casec No. of screen-positive/NPC cased Taiwanese multiplex family members (40+) 762/100,000a 80%b 58% 164 69 Taiwanese multiplex family members (40+) 762/100,000 90%e 40% 146 88 -
↵aEleven NPC cases were ascertained among 1,444 high-risk Taiwan multiplex family study participants at least 40 years of age at the time of the baseline blood draw (14).
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↵bSensitivity and specificity generated from EBNA1 IgA COV = 0.72.
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↵cNumber of screened per NPC case detected = 1/(sensitivity × 5-year NPC risk).
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↵dNumber of screen-positive per NPC case detected = 1/(positive predictive value).
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↵eSensitivity and specificity generated from EBNA1 IgA COV = 0.61.
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- Table 4.
Application of less specific screening tools for incident NPC in high-risk multiplex Taiwanese family members (40+ years of age)
IgA marker 5-year NPC risk Sensitivity Specificity No. of screened/NPC case No. of screen-positive/NPC case VCAp18 762/100,000 82% 20% 160 128 VCAp18 + EBNA1 762/100,000 81% 54% 162 75
Supplementary Data
Files in this Data Supplement:
- Supplementary Figure Legends - PDF file - 46K
- Supplementary Figure 1 - PDF file - 49K, ROC curve for VCAp18 IgA marker (delta=0.08).
- Supplementary Figure 2 - PDF file - 50K, ROC curve for combined VCAp18 + EBNA1 IgA marker (delta=0.98).
- Supplementary Table 1 - PDF file - 70K, Application of EBNA1 IgA as a Screening Tool for Incident NPC in varying Target Populations.
Volume 23, Issue 7
